PubMed Health⌕ Search

Biomedical subjects

M Kozma

Publications and source records attributed to M Kozma.

13 recordsLinked to original sources
PubMed1989

[Results of 3-year study of toothbrushing with a fluoride amine gel].

265 6-year-old children were investigated over a period of 3 years. In the test group, 6 toothbrushing exercises and 25-30 controlled applications of Elmex Gelèe were carried out yearly. The effect was analyzed by oral hygiene, caries frequency, caries intensity, and caries increase. The improvement of the oral hygiene index according to Silness-Löe was 30% and can be characterized as highly statistically significant (p less than 0.001). The inhibition of caries increase related to the surface (delta DMF-S) was 53% in the case of caries with substance loss and was also highly significant.

Amines↗
PubMed1988

Vasoactive intestinal peptide synergistically stimulates DNA synthesis in mouse 3T3 cells: role of cAMP, Ca2+, and protein kinase C.

Vasoactive intestinal peptide synergistically stimulated initiation of DNA synthesis in Swiss 3T3 cells. The peptide stimulated [3H]thymidine incorporation in the presence of insulin and either forskolin or an inhibitor of cAMP phosphodiesterase in a concentration-dependent manner. Half-maximal effect was obtained at 1 nM. At mitogenic concentrations, VIP stimulated a marked accumulation (eightfold) of cAMP. In contrast to other growth-promoting neuropeptides, VIP did not induce an increase in cytosolic free Ca2+ or an activation of protein kinase C. We conclude that neuropeptides can modulate long-term cell proliferation through multiple signaling pathways.

Animals↗
PubMed1979

Histochemical and atomic absorption demonstration of trace metal mobilization in the central nervous system and liver of the rat.

Histochemical and atomic absorption spectrophotometric analysis of trace metal mobilization caused by the action of ethanol in the central nervous system (CNS) and liver of the rat is described. Histochemically it has been shown that in all neurons examined (motoneurons, pyramidal and Purkinje cells) the trace metals (mainly Zn2+ and Cu2+) are mobilized. Most of the stained materials disappear from the perikaryon of the Purkinje cells, while in both the motoneurons and the pyramidal cells the trace metals are displaced from the perikaryon into the axon and axon hillock. At the same time, some of the glia cells display a high metal content. Quantitative determination of the Zn2+ and Cu2+ by means of atomic absorption spectrophotometry reveals that after 2 hours ethanol treatment both the Zn2+ and the Cu2+ levels are decreased in the archicerebellar cortex, while after 4 hours the Zn2+ levels are increased in the cerebrum and the spinal cord. The present observations on the histochemical localization and the contents of zinc and copper in different parts of the CNS and liver reveal the important role of the effect of ethanol on the trace metal mobilization.

Animals↗
PubMed1979

Trace element localization and changes in zinc and copper concentrations during postnatal development of the rat CNS.

Changes in concentration and localization of the trace metals during postnatal ontogenetic development in the archi-, paleo-, and neurocerebellum, the cortex and the spinal cord of the rat have been studied by means of histochemical and atomic absorption spectrophotometric analysis. It has been shown that the trace elements in the different regions of the nervous system become progressively detectable during the postnatal ontogenesis, and in the various structures (PURKINJE cells, pyramidal cells, motoneurons, mossy-fibre terminals) different times are necessary for the attainment of the localization observed in the mature animals. It is suggested that the trace elements may be transported not only intraneuronally, but also from neuron to neuron, from neuron to glia cell, and in the reverse direction, too.

Animals↗
PubMed1978

Ultrastructural identification of neural elements containing trace metals.

The quantitative distribution of heavy metals in the central nervous system was studied by atomic absorption spectrophotometry. It was shown that, of the regions studied, the archicerebellar cortex contains the highest levels of metals. A light microscopical histochemical technique (TIMM silver sulphide method) reveals the neurons and glial cells which possess the trace elements. Ultrastructurally, the staining occurs in different axon terminals, lysosomes, neuronal surface membranes and the cytoplasm of glial cells.

Animals↗
PubMedDate not supplied

Autoradiographic study with 14C-labelled pentagastrin in the rat.

An autoradiographic light-microscopic study was made to attempt to follow the course of metabolism and elimination of glycine labelled pentagastrin in rat. It was found that even 10 seconds after the intravenous injection of 14C-labelled pentagastrin, activity can be observed in the liver and in connection with the parietal cells of the gastric mucosa; the radioactive grains remain in the hepatocytes for a prolonged period, whereas they disappear very quickly from the stomach. Activity can be detected in the renal tubuli 2 minutes or more after labelled pentagastrin administration.

Animals↗
PubMedDate not supplied

[Wire/composite splinting of traumatically injured permanent teeth].

For splinting traumatically loosened and/or reimplanter remaining front teeth wire splints are used which are fixed by means of composite substance, gluing technique. Kinds of employed splints are disclosed and the steps of the practical carrying out of splinting are described. Indications, advantages and disadvantages of its employment are discussed.

Adolescent↗