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Biomedical subjects

M Krasnianski

Publications and source records attributed to M Krasnianski.

5 recordsLinked to original sources
PubMed2003

[Facioscapulohumeral muscular dystrophy. The spectrum of clinical manifestations and molecular genetic changes].

Although the gene for facioscapulohumeral muscular dystrophy (FSHD) has not been identified so far, 4q35 deletion represents a diagnostic marker of the disease. In the present study, 46 consecutive symptomatic patients with 4q35 FSHD deletions or typical FSHD clinical features were evaluated. The patients were divided into three groups: 33 patients (72%) with typical FSHD phenotype and 4q35 FSHD deletion, eight (17%) with atypical (non-Landouzy-Dejerine) FSHD phenotype but with 4q35 FSHD deletion, and five patients (11%) with the typical FSHD phenotype but without FSHD 4q35 deletion. Apparently, the 4q35 deletion is associated not only with Landouzy-Dejerine FSHD but also with a variety of "atypical" FSHD forms. On the other hand, the Landouzy-Dejerine FSHD phenotype is possibly a polyetiological syndrome caused in some patients by other genetic effects than 4q35 deletion.

Adolescent↗
PubMed2003

[Classical crossed syndromes of the medulla oblongata. A historical and topodiagnostic discussion].

Historical publications of the classical alternating medulla oblongata syndromes of Wallenberg, Babinski-Nageotte, Cestan-Chenais, Hughlings Jackson, Avellis, Schmidt, Dejerine, Spiller and Tapia were reviewed and critically analysed. We compare these descriptions with descriptions of the brainstem syndromes in well-known modern German, English and Russian neurological textbooks. The anatomic basis and etiology of the alternating medullar syndromes, and the main publications relating to these syndromes were discussed. Causes of the inconsistencies of the modern and historical descriptions of these syndromes might be an ignorance of the historical references. Progress and development of the clinical neurology and neuroanatomy in the late twentieth century, however, has also lead to correction and perfection of some historical descriptions in the modern neurological literature.

Brain Diseases↗
PubMed2002

Brainstem infarctions with normal MRI.

Most studies on brainstem infarctions included only patients with lesions documented by CT or MRI. The aim of this study was to analyse the clinical symptomatology in patients with the classical signs of brainstem infarcts and normal MRI results. Frequencies of MR-positive and negative infarctions should be analysed according to their location. In a series of 30 consecutive patients with acute clinical symptoms of ischemic brainstem lesions and persistence of the symptomatology for more than 10 days, 8 patients had normal MRI. In these patients the location of the lesion was established by clinical and electrophysiological criteria. The lesions in the 8 patients with normal MRI were situated in medulla oblongata (n=3), in pons (n = 2), and in midbrain (n = 3). In each of these patients the clinical symptoms corresponded to one of the classical alternating syndromes, which are pathognomic for brainstem infarctions (1 Wallenberg, 1 Avellis, 1 Jackson, 2 Millard-Gubler, and 3 Weber). The clinical course of the infarctions with normal MRI was favourable, the symptoms disappeared within few weeks. Our study proved that the clinical diagnosis of brainstem infarction, particularly in lesions of midbrain and caudal tegmentum pontis, can not be excluded by normal MRI.

Aged↗
PubMed2001

[Correlation of clinical and magnetic resonance imaging findings in patients with brainstem infarction].

The aim of this study was the comparison of clinical and neurological findings in 30 patients presenting with ischemic brainstem lesions. These were localized in the midbrain in 4 cases, in the medulla in 12 cases and in the pons in 11 cases, while the remaining three patients demonstrated combined lesions. Symptoms were lesions of the pyramidal tract in 77% of cases, vertigo in 57% of cases, speech disturbances in 40% of cases and gait ataxia in 37% of cases. Cranial nerve lesions were evident in 87% of patients, while 33% of patients demonstrated a Horner syndrome. Brainstem lesions were diagnosed in 22 (73%) of patients on magnetic resonance imaging, while all 30 patients had clinical signs suggestive of brainstem lesions. We conclude that neuroradiological studies can provide helpful information regarding patients with brainstem lesions, but by no means replace exact neurological examination.

Adult↗