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Biomedical subjects

M Krishnamurthy

Publications and source records attributed to M Krishnamurthy.

At least 37 records · Page 2Linked to original sources
PubMed1992

Strain-gauge evaluation of lunate unloading procedures.

A biomechanical study was undertaken to determine which procedure(s) most effectively relieve load from the lunate. Strain gauges were mounted on the lunates of 20 preserved cadaveric limbs. Three types of procedures were performed: scaphotrapeziotrapezoid arthrodesis, capitohamate arthrodesis, and ulnar lengthening. Load testing was performed both before and after the simulated fusions and ulnar lengthenings. Ulnar lengthening of 3 mm was the most effective method of lunate strain reduction. Capitohamate arthrodesis decreased compressive strain but increased shear strain. Scaphotrapeziotrapezoid fusion significantly increased both compressive and shear strain in the lunate. Of the three procedures that were tested, ulnar lengthening to create a neutral variance is the most reliable means of unloading the lunate.

Analysis of Variance↗
PubMed1988

Adult T-cell leukemia/lymphoma in Brooklyn.

Fifteen patients with adult T-cell leukemia/lymphoma (ATLL) were identified in less than a two-year period in the Crown Heights-Bedford Stuyvesant section of Brooklyn, NY. All patients were black; nine patients originated from the Caribbean islands and six from the southern United States. Two of the patients were father and daughter, the first evidence of familial occurrence in the United States. Their clinical course was similar to that of previously described patients with this disorder. To our knowledge, these 15 patients represent the largest series of ATLL reported in the United States. We recommend that ATLL be seriously considered in the differential diagnosis of patients with non-Hodgkin's lymphoma, mycosis fungoides, lymphatic leukemia, or hypercalcemia.

Adult↗
PubMed1988

The first report of familial adult T-cell leukemia lymphoma in the United States.

Two patients, a daughter and her father, developed the acute type of adult T-cell leukemia/lymphoma (ATLL) within a 3-month period. Antibodies against HTLV-I have been found in both wives of the father. The second wife acquired the infection from her husband within 3 years of marriage. The patients described represent the first cases of familial ATLL in the United States. ATLL continues to be frequently misdiagnosed in the United States. A positive family history consistent with this disease in a patient with a lymphoid malignancy may be a helpful clue for earlier diagnosis.

Adult↗
PubMed1987

Chromosomal abnormalities in adult T-cell leukemia/lymphoma (ATL). A report of six cases with review of the literature.

Chromosomal studies were performed on six patients with adult T-cell leukemia (ATL). Structural abnormalities of chromosome 3 were the most common. In one case a complete loss of the short arm of chromosome 10 (10 p-) was noted while in another case a balanced translocation involving chromosome 10p and 4q was found. These abnormalities have not been previously reported. After reviewing the literature, it was concluded that chromosomes 3, 6, 10, 13, 14, and X were most frequently involved in abnormalities. Specific and consistent chromosomal abnormalities were noted in each study. Therefore, it is hypothesised that the mutation rate for this virus may be higher than first expected. Furthermore, the relative consistency of heterogeneous findings in different localities may reflect a geographic clustering of specific chromosomal abnormalities which may in turn be related to specific and geographically associated viral mutations. To support these suggestions not only are more cytogenetic data required but a molecular evaluation of these patients must be carried out to establish a relationship, if any, between genetic abnormalities and the epidemiology of ATL.

Adult↗
PubMed1985

Extramedullary presentation of blast crisis in chronic myelogenous leukemia.

We present a case with the clinical and pathological impression of Ph1-positive chronic myelogenous leukemia in extramedullary blast crisis involving lymph nodes as demonstrated by morphological and cytogenetic studies. The hyperploid cell lines that were present in the lymph node were not present in the bone marrow. The present case demonstrates that cytogenetic and morphological studies of extramedullary organs are helpful in the confirmation of the diagnosis of blast crisis, especially when lymph nodes are the site of original presentation.

Adult↗
PubMed1980

Psychosocial aspects of sickle-cell anemia in adolescents.

Until recently emphasis has been placed solely on the physical aspects of sickle-cell anemia. However, a study of twenty-one adolescent sickle-cell patients of both sexes revealed severe emotional and social problems. A task-oriented group approach used with some of these patients had positive results, including free flow of communication, motivation and interest in the group, and increased independence.

Adaptation, Psychological↗
PubMed1977

Granulocytic sarcoma of the brain.

An unusual case of granulocytic sarcoma (chloroma) of the parenchyma of the brain occurring in a patient with acute myelocytic leukemia in remission is described and the literature reviewed. The patient presented with an intracranial mass without clinical evidence of meningeal involvement. The value of 99mTc scan in CNS leukemia is shown.

Brain Neoplasms↗
PubMed1977

Von Willebrand's disease and pregnancy.

The course of a pregnant patient with von Willebrand's disease, who underwent a successful cesarean section without supportive Factor VIII therapy is described. She had no postoperative bleeding despite a persistently prolonged bleeding time. The significance of the bleeding time, Factor VIII activity, and Factor VIII-related antigen in relation to bleeding tendency and therapeutic management is discussed.

Adult↗