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Biomedical subjects

M Krizko

Publications and source records attributed to M Krizko.

16 recordsLinked to original sources
PubMed2002

[Premature fetal membrane rupture after amniocentesis in the second trimester and successful use of fibrin glue--case report].

OBJECTIVE: The aim of this study was to evaluate fibrin sealing in management of premature rupture of membranes after amniocentesis in early second trimester. DESIGN: Case report. SETTING: II. gynekologicko-pôrodnícka Klinika LFUK NsP Ruzinov, Bratislava; Department of Obstetrics and Gynecology, Spectrum Health--Blodgett Campus, Grand Rapids, USA. SUBJECT AND METHOD: In this case report authors report the use of fibrin sealant (Tissucol KIT, Immuno, A) in management of premature rupture of membranes after genetic amniocentesis. The sealing was performed in 19 + 0 week of pregnancy, 15 days after amniocentesis. The pregnancy was terminated by caesarean section in 34-th week, 98 days after sealing. The newborn was in stable condition, without clinical or laboratory signs of infection. No skeletal deformities or adverse effects of fibrin sealant were observed. Neurological examination in 3 month of age evaluates the psychomotorical development as normal. CONCLUSION: We consider the perinatal outcome of this pregnancy as positive.

Adult↗
PubMed2000

Autoimmune thyroiditis with severe hypothyroidism resistant to the treatment with high peroral doses of thyroxine: case report.

Female patient (42 yr) suffered from autoimmune thyroiditis resulting in severe hypothyroidism. She was treated for several years by district physician with the dose of 150 microg L-thyroxine daily. Since the level of TSH was repeatedly very high and no improvement of clinical signs has been observed, she was referred to the Medical Faculty Hospital. Thyroid ultrasound showed remarkable diffuse hypoechogenicity, thyroid scintigraphy showed enlarged thyroid with low 99mTc uptake, TRH test was normal, thin needle biopsy supported autoimmune thyroiditis. X-ray examination showed normal sella turcica and no changes in the pituitary were observed with computer tomography. In spite of increasing the dose of peroral L-thyroxine to 300 microg/d and later to 500 microg/d the clinical status and TSH level did not improve. The patient was originally suspected from malabsorption of thyroxine. However, the test with a large single peroral dose (1000 microg) of L-thyroxine showed a rapid decrease of TSH level (from 126 to 75 mU/l) and increase of total T4 level (from 18 to 64 nmol/l) within 4 hr. Later the patient has been treated with intravenous L-thyroxine (500 microg every 3-4 days for 4 weeks) which resulted in the decrease of TSH level to 10 mU/l and increase of T4 level to 80-100 nmol/l. After that it was concluded that the problem is a poor compliance of the patient who apparently does not actually take the medication, although she always claimed that she is doing so. Referring to some similar cases described in the literature the case was classified as thyroxine pseudomalabsorption. In spite that this problem has been explained to her and her relatives, she refused to take any medication and is consistently neglecting all invitations to further examinations.

Administration, Oral↗
PubMed1999

Vitamin 1,25-(OH)2 D3 concentrations in patients hospitalized long-term.

Vitamin D deficiency may be one reason for the onset and development of osteoporosis. The aim of the present study was to determine the occurrence rates of hypovitaminosis D in an unselected group of individuals presenting with common medical conditions and hospitalized for long periods. Concentrations of 1,25-(OH)2 D3 were measured in 89 patients (38 males and 51 females). Mean age was 70 years. Thirty-eight patients were tested in the spring and the remaining 51 patients in the autumn. Vitamin D3 levels were significantly reduced in patients tested in the autumn (p < 0.001). The reason for this surprising observation may have been the small number of sunny days and the long hospital stays during the study period, differences in the composition of both groups and the fact that 1,25-(OH)2 D3 reflects the actual vitamin D3 levels rather than those of its reserve in the human body. The results obtained suggesting hypovitaminosis D in an unselected group of elderly patients hospitalized with common diseases, even after the summer season, suggest the need for general supplementation of this vitamin throughout the year, regardless of the risk factors.

Aged↗
PubMed1990

[Lipid composition of the myometrium during labor].

Lipids represent one of the basic components of each cellular and subcellular membrane of the myometrium and their fluidity has a strong influence upon membrane function. Human myometrium was obtained at cesarean sections. Lipids were separated by one-dimensional thin layer chromatography. The chromatoplates were determined on the densitometer Shimadzu CS 930. Lipid profile of the myometrium was studied before the 37th week of pregnancy, at term without contractile activity, further during at term labor with normal contractile activity and at failure of myometrial contractility. Analysis of the obtained data showed changes in lipid fluidity, namely a decrease before the 37th week of pregnancy and at failure of myometrial contractions during at term labor. The decrease of fluidity was caused by a higher content of total cholesterol and a lower content of total phospholipids in the myometrium.

Female↗
PubMed1990

[Phospholipids in the human myometrium in various stages of contraction before and during labor].

A detailed analysis of the myometrium showed that the physical state of phospholipids--fluidity--depends on the ratio of their individual components and changes in relation to the state of contractile activity. The results indicate that before term of labor changes in the fluidity of myometrial phospholipids as well as increased availability of arachidonic acid for prostaglandin synthesis can induce preterm onset of contractile activity. Possibilities of affecting these mechanisms, which belong to the many potential factors inducing preterm labor, are discussed.

Female↗
PubMed1989

[Incidence of macroscopic changes in the placenta in intrauterine growth retardation in neonates].

Advances in noninvasive imaging techniques allow to visualize the placenta and changes of its structure in the course of gestation. Macroscopic examination of the placenta in newborns with intrauterine growth retardation reveals changes responsible for reduced placental functions. These can then be diagnosed in utero, e.g. by ultrasonographic examination. The most serious defects include reduced weight an insertion area of the placenta and infarcts covering more than 6% of the placental area. Extrachorial placentas also have adverse effects. Other macroscopic changes do not appear to be causally associated with intrauterine growth retardation and have been recorded to a comparable extent also in placentas of eutrophic newborns.

Female↗