PubMed Health⌕ Search

Biomedical subjects

M Kubícková

Publications and source records attributed to M Kubícková.

8 recordsLinked to original sources
PubMed1994

[Changes in hemocoagulation during thrombolytic therapy of acute myocardial infarct in relation to risks of thrombotic complications].

In 38 patients with acute myocardial infarction treated with 1.5 million u. of streptokinase hemocoagulation parameters were assessed before and after treatment and after another 12, 24 and 48 hours. The authors revealed three risk indicators of thrombotic complications: 1. a shortened aPTT before treatment and at the same time a less than double prolongation of aPTT, as compared with control plasma after treatment (P < 0.01, sensitivity 0.67, specificity 0.81). 2. A non-detectable fibrinogen level (less than 1.1 milligrams) 24 hours after termination of treatment (P < 0.05, sensitivity 0.59, specificity 0.71). 3. The third risk factor 3 is a combination of the previous two: shortened aPTT before treatment and at the same time its inadequate prolongation after treatment and/or an undetectable fibrinogen level 24 hours after treatment (P < 0.001, sensitivity 1.00, specificity 0.57). In all the authors' patients with thrombotic complications (reinfarction, recurrent myocardial ischaemia, extended infarction, intracardiac thrombosis, embolization into the CNS) this 3rd combined risk factor was positive.

Female↗
PubMed1992

[Thrombolysis of arterial retinal occlusion using urokinase].

The authors present an account on possible aimed thrombolytic treatment of occlusion of the retinal artery by urokinase. Aimed thrombolysis can be performed at ophthalmological departments with an available radiodiagnostic department, which performs angiographies of carotid arteries. The authors discuss the necessary dose of 200,000 to 300,000 i.u. of urokinase. One-hour infusion with an initial booster dose is best. Early administration of the preparation is considered most important by the authors. The authors present the case-history of a 34-year-old patient with complete occlusion of the central retinal artery with haemodynamically severe aortal stenosis with a congenital background. Urokinase was administered six hours after occlusion of the artery. Gradually reperfusion of the retina occurred and improvement of the visual acuity from 0.01 to 0.17 with a residual relative wedge-shaped loss of the visual field and paleness of the disc of the optic nerve.

Adult↗
PubMed1982

Early response of lymphatic system to experimental infection with Mycobacterium kansasii and Mycobacterium scrofulaceum.

Weight, cellularity and metabolic activity (nucleolar test) of draining and contralateral popliteal lymph nodes were studied in groups of guinea pigs infected intratarsally in right hind limb with Mycobacterium kansasii (2.4 x 10(6) viable units) and Mycobacterium scrofulaceum (3.4 x 10(6) viable units) species and examined 1, 3, 7 and 14 days after inoculation. Time-related differences and inter-group differences in cellularity and per cent of active lymphocytes were statistically analyzed by paired t-test. Experimental animals infected with the two mycobacterial species showed at all time intervals a significant increase in weight, cellularity and per cent of active lymphocytes in draining lymph nodes as compared to contralateral nodes and to control values. Infection with M. kansasii produced a more significant increase in all the parameters studied than inoculation with M. scrofulaceum. These differences are in agreement with the different pathogenic activity of these two species of the potentially pathogenic mycobacteria. Early activation of lymphatic tissues occurring within the first 24 hours after inoculation results from the action of some cellular immunity mediators is released already at the early phases of lymphocyte-antigen interaction.

Animals↗
PubMed1980

In vitro studies of cell-mediated immunity in rabbits sensitized with Mycobacterium kansasii and Mycobacterium tuberculosis.

Rabbits, sensitized with M. kansasii, responded by a profound inhibition of migration of macrophages elicited by both antigens: the migration index for homologous antigen was 0.51 in the direct test and 0.65 in the indirect test; for heterologous antigen the indexes were 0.53 and 0.67. However, significant differences in reactivity were found in rabbits sensitized with M. tuberculosis. In the homologous system, high reactivity was maintained and the migration index reached the value of 0.53 in the direct and 0.63 in the indirect test. On the other hand, the heterologous antigen M. kansasii influenced the migration in both direct and indirect assays significantly less, the migration indexes being 0.62 and 0.72. The differences were statistically significant at 1% and 5% levels.

Animals↗