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Biomedical subjects

M Kveim

Publications and source records attributed to M Kveim.

9 recordsLinked to original sources
PubMed1985

Early tongue resection for Beckwith-Wiedemann macroglossia.

Dentists are aware of the extraordinary influence an active thrusting tongue can have on dental development. In the presence of the profound muscle hypertrophy characteristic of macroglossia in the Beckwith-Wiedemann syndrome, a compelling need exists for surgical reduction of the tongue as early in life as possible. This report describes our clinical experience with 3 children, 1 referred late and the other 2 treated within the first year of life.

Beckwith-Wiedemann Syndrome↗
PubMed1979

A gas chromatographic method for determination of acetate levels in body fluids.

A simple, sensitive and accurate gas chromatographic method for the determination of acetate in plasma and urine is described. Following precipitation of proteins by perchloric acid and removal of potassium perchlorate by precipitation with KOH, acetic acid is quantitated by injection of the acidified sample on a highly polar column. A flame ionization detector is used. Propionic acid is added to the sample initially as internal standard. The sample volume required for the analysis is 0.5 ml. The standard curve is linear in the range from 0.01 to 10 mmol/l. Recovery of added acetate is complete, and the coefficient of variation is less than 4% even at low concentrations. The concentration of free acetate in plasma from 10, and urine from 4, healthy humans ranged from 0.04 to 0.07 and 0.09 to 0.24 mmol/l, respectively.

Acetates↗
PubMed1979

Plasma acetate concentrations during canine haemorrhagic shock.

Acetate, pyruvate, lactate and NEFA concentrations, as well as acid-base-parameters were followed during bleeding, stable hypotension and re-infusion in five dogs. Mean arterial blood pressures were kept at 30 mmHg during the shock phase. An increase in acetate concentrations (P less than 0.01) was found in arterial as well as in venous plasma samples. The maximal mean acetate concentration was 0.19 mmol/l (during reinfusion) as compared to 0.06 mmol/l prior to bleeding. There was no difference between arterial and inferior caval venous concentrations. A definite correlation (r = 0.81, P less than 0.02) was found between blood pyruvate and plasma acetate concentrations. There was no correlation between plasma glucose or NEFA and acetate concentrations or between blood excess lactate and plasma acetate. The plasma acetate accumulation was negligible compared to the concomitant lactate accumulation (1:60), and did not contribute to the metabolic acidosis of shock. The correlation between acetate and pyruvate concentrations may indicate that pyruvate is the main substrate of acetate production in hypovolemic shock.

Acetates↗
PubMed1979

Utilization of exogenous acetate during canine haemorrhagic shock.

Plasma acetate and lactate, as well as acid-base-parameters were followed during acetate (dogs I-V) or lactate (dogs VI-X) loading during stable hypotension (mean arterial blood pressure 30 mmHg). Acetate or lactate were infused at a constant rate of 4 mmol/kg/h as 0.5 mol/l solutions (50% as the sodium salt, 50% as the free acid) without simultaneous treatment of the volume deficit. The acetate metabolizing capacity was well preserved even in profound haemorrhagic shock. The actual loads were rapidly removed, while the equivalent lactate loads caused progressive accumulation of the lactate ion. Acetate loading did not aggravate the lactic acidosis, and the acid-base-parameters showed a more favourable development during acetate loading than during lactate loading. Acetate may thus be given during haemorrhagic shock without the same risk of accumulation that is carried by the equivalent amounts of lactate.

Acetates↗
PubMed1979

Acetate production and substrate availability in the dog.

Arterial plasma acetate, glucose and NEFA concentrations were measured during loading with glucose/insulin and fat emulsion/heparin, and during epinephrine and norepinephrine stimulation in dogs. The expected alterations in glucose and NEFA concentrations were found. Acetate concentrations were not influenced, and remained constant in all experiments. Since acetate removal from the body pool is mainly concentration dependent, it may be concluded that acetate production was constant under the conditions described. "Overflow disposal" of AcSCoA to yield free acetate in cases of high rates of AcSoA-production does not occur as long as the Krebs cycle is intact.

Acetates↗
PubMed1976

Intra-aortic balloon pumping in the treatment of cardiogenic shock following open-heart surgery.

Intra-aortic balloon pumping (IABP) was used in the treatment of 29 patients in cardiogenic shock refractory to pressor drugs subsequent to open-heart surgery. Nineteen patients recovered from the shock primarily, but four died later in hospital. The remaining 15 were discharged alive. Peroperative electromagnetic flow measurements in one patient showed a 23% increase in aortic flow and a 26% increase in aortocoronary bypass flow when pumping was started.

Adult↗