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Biomedical subjects

M L Burr

Publications and source records attributed to M L Burr.

At least 91 records · Page 5Linked to original sources
PubMed1987

Atrophic gastritis and vitamin C status in two towns with different stomach cancer death-rates.

A survey was conducted of 513 men aged 65 74 years living in two British towns with high and low stomach cancer death-rates. The prevalence of severe atrophic gastritis (defined as a serum pepsinogen I less than 20 micrograms l-1) was significantly higher in the high-risk than in the low-risk town (14.5% and 7.7% respectively); it also tended to be higher in the manual workers, who are known to have a greater risk of stomach cancer than non-manual workers. The manual workers in the high-risk town were particularly likely to have had a partial gastrectomy. Plasma ascorbate concentration and fruit intake were lower in the high-risk area and lower social classes, suggesting a poorer vitamin C status. There was, however, no direct relationship between ascorbate concentration and the presence of severe atrophic gastritis. These findings are consistent with the hypothesis that risk of stomach cancer is determined in two stages--a long-term effect, producing atrophic gastritis; and a short-term effect in which vitamin C is protective.

Aged↗
PubMed1987

Why is chest disease so common in South Wales? Smoking, social class, and lung function: a survey of elderly men in two areas.

A respiratory survey was conducted in two British towns, one with a high mortality (Caerphilly) and one with a low mortality (Bath) from respiratory disease. A total of 513 men aged 65-74 years were seen. The Caerphilly men had poorer lung function than the Bath men; the overall difference in FEV1 and FVC for men aged 70 and 1.68m tall was 0.16 1 and 0.17 1 respectively. These differences appeared to be largely due to the greater tendency of the Caerphilly men to smoke and to an effect related to social class. Respiratory symptoms were also more common in Caerphilly, principally because of the effects of smoking and occupational group, although when these factors were allowed for there was still a significantly greater prevalence of breathless wheezing in Caerphilly.

Aged↗
PubMed1986

Alcohol and high-density-lipoprotein cholesterol: a randomized controlled trial.

1. A randomized controlled trial of cross-over design was set up to examine the effect of alcohol on blood lipids and certain haematological variates relevant to ischaemic heart disease. 2. One hundred subjects drank some alcohol for 4 weeks (mean intake 18.4 g/d) and abstained totally for 4 weeks, the order of these periods being randomized. 3. Alcohol appeared to produce a rise of 7% in serum high-density-lipoprotein (HDL) cholesterol, probably due to a rise in the HDL2 subfraction. 4. No significant change was detected in plasma fibrinogen or the other haematological indices. 5. These results are consistent with the hypothesis that a moderate intake of alcohol confers some protection against heart disease.

Adult↗
PubMed1986

Heart rate, employment status, and prevalent ischaemic heart disease confound relation between cereal fibre intake and blood pressure.

Cross sectional data from a survey of 2512 men aged 45-49 years were used to examine the confounding effects of heart rate, employment, and ischaemic heart disease (IHD) on the relation between cereal fibre intake and blood pressure. Daily cereal fibre intake (g/day) was associated with systolic pressure (r = -0.053, p less than 0.01), diastolic pressure (r = -0.057, p less than 0.01), and heart rate (r = -0.071, p less than 0.01). The associations were strengthened in employed men and inapparent in unemployed men. Unemployed men had more IHD than employed men. Persons with any manifestation of IHD had significantly higher blood pressure and heart rates but ate less cereal fibre (7.0 v 7.9 g/day, p less than 0.001) than those without IHD, regardless of employment status. In employed men, after adjustment for age, body mass index, prevalent IHD, and heart rate, systolic pressure changed -0.186 mmHg (95% CI = -0.362, -0.009) and diastolic pressure changed -0.111 mmHg (95% CI = 0.228, 0.005) for each gram of cereal fibre eaten daily. The association between cereal fibre and blood pressure was inapparent in unemployed men. Heart rate, employment, and prevalent IHD confound the association between cereal fibre intake and blood pressure. Future work concerning this relationship will have to account for the effects of these variables.

Blood Pressure↗
PubMed1986

A randomised controlled trial to investigate the effect of a high fibre diet on blood pressure and plasma fibrinogen.

Two hundred and one subjects (147 men and 54 women) were randomly allocated to either a high cereal fibre diet or a low cereal fibre diet for four weeks. Each group then followed the alternative diet for a further four weeks. Cereal fibre intakes were 19g/d (31 g/d 21 g/d total fibre) and 6g/d (19g/d total fibre) on the high and low fibre diets respectively (p less than 0.001). Energy, protein, fat, carbohydrate, and alcohol intakes calculated from weighed intake records did not differ between the two diets, although there was a slight difference in body weight, the mean being 0.3 kg heavier at the end of the high fibre period. The high cereal fibre diet had no detectable effect on blood pressure or plasma fibrinogen.

Adolescent↗
PubMed1985

Lung function in the elderly.

Data are presented on the FEV1 and forced vital capacity (FVC) of elderly people living at home. These were derived from a survey of 418 persons over the age of 70 years and thus provide standards for the assessment of elderly persons. There was a decline in FEV1 and FVC cross sectionally with age and a continued adverse effect of smoking. A history of cough and phlegm was strongly related to impairment of lung function.

Aged↗
PubMed1985

Nutritional epidemiology.

Epidemiological techniques constitute an important method of nutritional investigation. Historical and geographical evidence suggests hypotheses which can be tested by more detailed studies. Cross-sectional surveys describe populations and provide information about prevalence; they also enable the interrelationships of various nutritional and physiological indices to be investigated. The case-control study is useful in exploring possible aetiological factors in diseases, but has the drawback that past dietary information is difficult to obtain accurately. Prospective studies identify predictors of disease and death; they are especially valuable in elucidating the natural history of disease, and supply good evidence on causation, but their duration and expense are disincentives to their use. Randomized controlled trials provide the most precise evidence about causation, and should be used whenever feasible to answer specific questions.

Aged↗
PubMed1985

A weighed dietary survey of women in South Wales.

Dietary intakes of 101 women living in a small South Wales town were measured by four day weighed inventory. Variation of nutrient intake with Body Mass Index (Quetelet Index) and age was also studied. Mean total energy was 1760 kcal (7.4 MJ); of this 42.9 per cent came from carbohydrate, 41.2 per cent from fat, 13.9 per cent from protein and 2.0 per cent from alcohol. Only cereal and total fibre intakes showed a gradual increase with age. Quetelet Index also increased with age; however there was a small negative correlation between carbohydrate intake and Quetelet Index. The results are compared with data from Cambridgeshire.

Adolescent↗
PubMed1985

Food-allergic asthma in general practice.

A survey was undertaken to assess the importance of food allergy in asthma. Seventy-two asthmatics aged 15-60 years were identified in a general practice and compared with 72 controls matched for age and sex. A diagnostic procedure involving dietary elimination and challenge was carried out on those who thought food exacerbated their symptoms, together with those with concurrent eczema, positive skin tests to food or positive food IgE-RAST. The asthmatics more frequently had positive skin tests of IgE-RAST to food than the controls, but these tests proved to be rather non-specific in identifying provoking foods. One patient was found to be allergic to wheat and his clinical condition improved when wheat was removed from his diet. Two patients seemed to respond to other foodstuffs, but the effects were small, the foods (honey and peppermint) unimportant, and the patients' symptoms appeared to be largely due to other factors. Most cases of alleged food-induced asthma could not be confirmed by challenge testing. This survey suggests that some degree of provocation by food (excluding drink) affects at least 4 per cent of adult asthmatics, although in some of these patients it plays an unimportant part in the disease.

Adolescent↗
PubMed1984

Anthropometric norms in the elderly.

Anthropometric indices are presented for representative samples of elderly people in South Wales, based on over 1500 subjects seen during community surveys. Body mass index declined with age after 70 years in both men and women. Estimates of fat and muscle volume based on upper arm measurements also showed a decline with age, which was particularly steep for triceps skinfold thickness in women. These indices are in general similar to results that have been reported from other surveys within the UK; they suggest that Welsh old people have less fat and muscle than elderly Americans.

Aged↗
PubMed1984

Breast feeding, maternal smoking and early atheroma.

The anterior descending coronary artery was obtained from each of 160 subjects aged 2 to 30 years who died suddenly. The arteries were examined for early atheromatous changes and the mothers were asked about the way the children had been fed during early infancy. No evidence was found for the hypothesis that breast feeding confers protection against coronary artery disease. The mothers' smoking history at the time of the birth bore no relationship to the pathological findings in the arteries. It therefore seems unlikely that the type of feeding in infancy, or maternal smoking during pregnancy, are factors influencing the risk of coronary disease.

Adolescent↗
PubMed1984

The prevalence and progression of autoimmune thyroid disease in the elderly.

Thyroid antibodies were measured by an enzyme-linked assay system (ELISA) on a random sample of 414 asymptomatic elderly people aged 70 years or more in a South Wales town in 1977. The prevalence of elevated titres of microsomal antibodies was 15.4% and of thyroglobulin antibodies 13.3%; 8.5% had an elevation of both antibodies. Five years later thyroid function was evaluated in 51 (66.6%) of those people with raised antibody titres in 1977 and compared with a control group of 46 old people drawn from the original population. Significant fluctuations of microsomal and thyroglobulin antibody titres were observed in two thirds of the antibody positive group. Three people in the control group developed positive thyroid antibodies during this period. Only 1 person in the antibody positive group became hypothyroid. The prognostic significance of raised thyroid antibodies with or without elevated TSH levels is less in the elderly than in middle aged or younger people. The significance of the fluctuating antibody levels as measured by a more sensitive method remains to be determined.

Age Factors↗
PubMed1984

Total and specific IgG4 antibody levels in atopic eczema.

Total IgG4 and IgG4 antibody levels specific for 10 allergens (three inhaled and seven ingested) were measured by radioimmunoassay of sera taken from three groups of adult patients: (1) 32 cases of atopic eczema, (2) 28 cases of respiratory allergy and (3) 156 normal volunteers. In all three groups IgG4 antibody activity was mainly directed against common foods, and generally the group with atopic eczema had higher total and specific IgG4 levels than the cases of respiratory allergy, who in turn had higher titres than the normal group. There was within each group a tendency for men to have more total IgG4 than women and the difference was statistically significant among the normals. There was evidence of an IgG4 restricted response in atopic eczema because despite the group's elevated total IgG4 its total IgG4 remained within normal limits. Furthermore specific IgG4 was correlated with the corresponding specific IgE level in five of the 10 allergens examined. These results are generally consistent with the view that IgG4 levels are raised in cases of atopic eczema due to prolonged exposure to an allergen which initiated an IgE response.

Adolescent↗
PubMed1983

Food intolerance: a community survey.

1. A questionnaire inquiring about food intolerance was sent to a random sample of the electorate in a small South Wales town. Replies were received from 170 men and 305 women, the response rates being 87 and 93% respectively. 2. Adverse effects of some food were reported by 19% of men and 26% of women, or 14 and 18% respectively if minor digestive symptoms are excluded. Certain foods were thought to cause non-abdominal symptoms by 4% of men and 10% of women, and vomiting, diarrhoea or abdominal pain by 11% of men and 10% of women. 3. Plasma IgE was measured in a random subset of ninety-nine women and found to be significantly lower in those with major symptoms than in the rest. This suggests that allergy is probably not a common cause of food intolerance.

Female↗
PubMed1983

The effect of fatty fish on plasma lipid and lipoprotein concentrations.

The effect of fatty fish consumption on plasma lipid and lipoprotein concentrations was studied in 118 healthy men in a cross-over controlled trial. Subjects ate 100 g or more of fatty fish at least twice a week for 3 months, and little or no fatty fish for another 3 months. The mean plasma triglyceride concentration decreased significantly by 6.7% on the fish diet; there were no significant changes in plasma total cholesterol, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol. A realistic intake of fatty fish has a detectable effect on blood lipids.

Animals↗