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Biomedical subjects

M L Chance

Publications and source records attributed to M L Chance.

At least 55 records · Page 3Linked to original sources
PubMed1979

Isoenzyme characterization of Leishmania species from Iraq.

Leishmaniasis in Iraq takes both the visceral and cutaneous forms. The causative organisms are identified according to the electrophoretic variation of the enzymes MDH, GPI, 6PGD, PGM and IDH. The 37 visceral stocks investigated fall into two groups which differ only with respect to GPI. The six cutaneous stocks were divided into three groups. Group 3 represents Leishmania major, while groups 4 and 5 refer to L. tropica showing intraspecific variation with regard to 6PGD.

Animals↗
PubMed1978

The chemotherapy of rodent malaria, XXIX DNA relationships within the subgenus Plasmodium (Vinckeia).

The relationships between rodent malarias were examined by means of DNA buoyant density determinations and DNA--DNA hybridization data. Current views of the existence in this group of four species: Plasmodium berghei, P. yoelli, P. vinckei and P. chabaudi were confirmed. The identity of two chloroquine-resistant lines derived from P. berghei N strain was established. One of these, the NS line, was found to be a subspecies of P. yoelii; the implications of this finding are discussed.

Animals↗
PubMed1978

The biochemical and serological taxonomy of Leishmania from the Aethiopian zoogeographical region of Africa.

The electrophoretic variation of the enzymes MDH, GPI, G6PGH, 6PGDH were determined for 68 strains of Leishmania isolated in the Aethiopian zoogeographical region. Other characters determined were the DNA buoyant density of nuclear and kinetoplast DNA and the excreted factor serotype. The strains could be readily identified on the basis of these characters thus assisting in the elucidation of epidemiological problems. On the basis of these characters the strains could be divided into six groups. Three of the groups corresponded to L. donovani s.l., L. major and L. aethiopica. The three other groups identified at present have no specific name associated with them.

Africa↗
PubMed1977

Species differentiation in the genus Leishmania by morphometric studies with the electron microscope.

Morphometric comparison of some ultrastructural features of leishmanial amastigotes demonstrated species-characteristic differences. These occurred in parameters relating to size, such as diameter and microtubule number; statistical analysis resolved four groups from the seven isolates studied. The results were not inconsistent with previous measurements, mostly with the light microscope, by other workers. The unqualified assertion that Leishmania species are morphologically identical is therefore no longer valid.

Animals↗
PubMed1977

Cutaneous leishmaniasis in the Libyan Arab Republic: preliminary ecological findings.

Preliminary results show cutaneous leishmaniasis in Libya to be, sometimes at least, a rural zoonotic infection. The parasites are transmitted, probably by Phlebotomus papatasi, between the rodents Psammomys obesus and Meriones libycus. The banks and 'islands' in the main channel of seasonal wadis provide the right combination of vegetation and permanence for the maintenance of an intense focus.

Animals↗
PubMed1976

Cutaneous leishmaniasis in the Libyan Arab Republic: distribution of the disease and identity of the parasite.

The endemicity of cutaneous leishmaniasis in northwest Libya was confirmed. Although the strains isolated from man had variable biological properties they were all biochemically similar according to the tests used. The Libyan strains resemble those of zoonotic cutaneous leishmaniasis in parts of the Middle East, but can be differentiated from urban or highland strains. It is suggested that the recent discovery of the disease is due partly to the improvement in medical services, and partly to the development of new areas of land for agriculture and housing.

Adolescent↗