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Biomedical subjects

M L Denbow

Publications and source records attributed to M L Denbow.

22 records · Page 2Linked to original sources
PubMed1997

Relationship between change in amniotic fluid index and volume of fluid removed at amnioreduction.

OBJECTIVE: To determine the relationship between the change in amniotic fluid index (AFI) and the volume of fluid removed at amnioreduction. METHODS: In a prospective study of 20 twin and 19 singleton pregnancies undergoing amnioreduction for severe polyhydramnios, AFI was measured immediately before and after the procedure and was correlated with the volume of fluid withdrawn. RESULTS: A significant linear relationship was found between AFI change and the volume drained in all pregnancies (Y = -4.2X; R2 = 0.49; P = .002). This relationship was similar in singleton and twin pregnancies. However, there was a significant absolute difference in AFI change between singleton and twin pregnancies of 7.9 cm (95% confidence interval 0.41, 15.2; P = .04). CONCLUSION: These findings support the use of the four-quadrant AFI as a semiquantitative index of amniotic fluid volume. This relationship can be used to predict the drainage volume required to achieve a target AFI with amnioreduction and thus avoid repeated AFI measurements during the procedure itself.

Adult↗
PubMed1997

Fetal testing in twins.

The incidence of twin pregnancies continues to rise with increasing use of assisted fertility techniques. The search for accurate methods of chorionicity determination and aneuploidy screening, and the outcome following multi-fetal pregnancy reduction dominate the recent literature. In addition, debate on the aetiology and management of the transfusional complications of monochorionicity continues.

Chromosome Aberrations↗
PubMedDate not supplied

Occlusion of arterio-arterial anastomosis manifesting as acute twin-twin transfusion syndrome.

In vivo, ex vivo and modelling studies suggest that arterio-arterial anastomoses (AAAs) protect against haemodynamic imbalance in monochorionic twins and thus the development of TTTS. We report the acute onset of severe TTTS at 34 weeks' gestation in a patient with an antenatally visualized AAA which was shown at injection studies to have been obliterated, presumably by thrombosis. Computer modelling with the relevant clinical data confirmed that occlusion of the AAA alone was sufficient to reproduce the clinical manifestations. A study of the vascular configuration of AAA in the fixed placenta suggested that its small diameter and turbulent flow may have contributed to its occlusion. This case report shows that the unmasking of unbalanced AVA configurations by occlusion of a protective AAA can manifest as TTTS.

Arterio-Arterial Fistula↗