Biomedical subjects

M L Faupel

Publications and source records attributed to M L Faupel.

3 recordsLinked to original sources

PubMed2001

Multimodal hyperspectral imaging for the noninvasive diagnosis of cervical neoplasia.

OBJECTIVE: To determine the ability of Multimodal Hyperspectral Imaging (MHI) to noninvasively detect, localize and diagnose cervical neoplasia. MATERIALS AND METHODS: The cervical epithelium was interrogated by MHI using tissue fluorescence and reflectance measurements after the probe was placed on the ectocervix. A Papanicolaou smear was taken, and a colposcopic examination was performed and cervical histologic specimens were collected, when indicated. MHI and Pap smear sensitivity and specificity data were compared with colposcopic and histologic results. RESULTS: Nineteen patients had CIN2 or higher, 30 had CIN1, 34 had benign cellular changes or metaplasia, and 28 were normal by both Pap smear and colposcopic examination. At equal specificity (70%) for both tests, the sensitivity of MHI was 97%, compared to 72% for the Pap smear. CONCLUSION: MHI detected cervical cancer precursors at a rate greater than that obtained by a simultaneously collected Pap smear.

Journal Article↗

PubMed1996

Prospective evaluation of skin surface electropotentials in Japanese patients with suspicious breast lesions.

The biofield breast examination (BBE) is a new, noninvasive and cost-effective method for diagnosing breast lesions currently undergoing multicenter evaluation in the USA and Europe. The test analyzes subtle differences in electrical potential caused by dysregulated epithelial proliferation. This report summarizes a prospective evaluation of BBE in a population of 101 patients with suspicious breast lesions scheduled either for open surgical biopsy or fine needle aspiration biopsy. Of the 101 patients included in the study, 49 were found to have a breast malignancy and 52 were found to have a benign breast lesion. BBE correctly identified 44 of 49 biopsy-proven cancers (sensitivity=90%) and correctly indicated no cancer in 31 of 52 biopsy-proven benign cases (specificity=60%). Sensitivity increased to 95% for cancers less than 2.5 cm in size. These results indicate that BBE may be an effective adjunctive test to help to resolve abnormalities discovered by physical examination or other screening methods.

Adult↗

PubMed1985

Steps in loudness summation.

The dependence of binaural loudness summation on interaural phase of tones ranging between 250 and 1400 Hz was investigated in a series of experiments using a loudness-matching procedure. Observers matched loudness of monaural-binaural and binaural-binaural pairs of alternating tones by adjusting the amplitude of one of the two. Adjustable and reference components of each tone pair were equal in frequency and were varied independently in interaural phase angle through the range +/- 177 degrees. For each tone frequency, steps in loudness summation of approximately 3 dB were obtained in the vicinity of a constant value of phase angle, theta t, which depends on the Hornbostel-Wertheimer constant (tau H) according to the relations theta t = 2 pi f tau H for tones of low frequency (f less than or equal to 1/2 tau H), and theta t = 2 pi(1 - f tau H) for tones of higher frequency (1/2 tau H less than or equal to f less than or equal to 1/tau H). Spatial relationships among alternating tones observed in the above conditions covaried with relative loudness in a complex manner, but exhibited qualitative changes in the vicinity of theta t.

Dominance, Cerebral↗