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Biomedical subjects

M L Joy

Publications and source records attributed to M L Joy.

4 recordsLinked to original sources

RF current density imaging in homogeneous media.

MRI has proven capable of imaging quasistatic volume current densities in electrolytic and biological media. In this paper, the feasibility of extending the method to image RF current density at the Larmor frequency is studied. RF current imaging could be relevant to MR power absorption and safety and to hyperthermia analysis, as well as creating dielectric and conductivity-dependent tissue contrast. The approach is to deliberately induce or inject RF currents in a sample synchronous with an MR pulse sequence and measure the resulting transverse RF magnetic field components. Current density is extracted by computing the curl of the magnetic fields. The preliminary theory has been developed for uniform media where both displacement and conduction currents exist while skin effects or eddy currents are absent. If the derivative in the B0 direction of the RF magnetic field component parallel to B0 is negligible, then sufficient information exists to reconstruct the RF current density component that is parallel to B0 without rotating the sample. The relative phase of the current can also be estimated. The method has been proven feasible by successfully imaging a uniform 85.6-MHz current density in a salt water phantom. The experiment conforms closely to capacitively coupled hyperthermia heating.

Artifacts

Pulsed NMR relaxometry of striated muscle fibers.

The longitudinal (T1) and transverse (T2) proton (1H) nuclear magnetic resonance (NMR) relaxation of fast- and slow-twitch muscle fibers are examined using rat muscle tissues in which one fiber type predominates. Both continuum and discrete exponential component fits are made to Carr-Purcell-Meiboom-Gill (CPMG) and inversion recovery pulse sequence measurements. In addition, experiments which illustrate the large sources of variability that have led to apparent conflicts in the literature are presented. Based on the results of this study, unique NMR features that distinguish fast- and slow-twitch muscle fibers are presented. The feasibility of differentiating fast- and slow-twitch muscle fibers using magnetic resonance (MR) imaging is briefly discussed.

Analysis of Variance

Quantitative two-dimensional time correlation relaxometry.

An experimental and analytical method is presented for obtaining two-dimensional NMR time correlation spectra of T1 (or T1p) and T2 exponential relaxation in heterogeneous samples. The numerical algorithms used in this study do not bias the solution by any a priori assumptions as to the number of required components. The constraints used to overcome the ill-posed and ill-conditioned nature of this inverse problem are also described. With this method, the correlations of T1 (or T1p) and T2 exponential components in systems of nonexchanging standards and rat muscle tissues are obtained.

Algorithms

Fourier multiaperture emission tomography (FMET).

We describe a new emission tomographic technique, using an Anger scintillation camera and a new family of coded apertures, in which a noniterative computer algorithm is used to reconstruct multiplanar images. The novel feature is a set of spatial narrow band filters that allow the depth information to be separated in the frequency domain. The position of the reconstructed planes can be selected at will. Using this technique, a planar resolution of 0.75 cm and a depth resolution of 1.6 cm have been measured at a depth of 10 cm and a magnification of 1. To demonstrate the potential of this system, the results of a phantom study are reported.

Fourier Analysis