Biomedical subjects
Publications and source records attributed to M L Labat.
In the osteopetrotic mutant rat "op", the white pulp of the spleen is poor in T lymphocytes, while the red pulp is hyperplastic in reaction to the aplastic bone marrow. Grafting of normal thymus into the mutant corrects these anomalies.
A graft of normal thymus performed after thymectomy can cure the lethal osteopetrotic condition of the "op" Rat. The beneficial effect of normal bone marrow injection can be suppressed by prior thymectomy of the "op" Rat. Thymus is likely to play a role in the pathogenesis of osteopetrosis.
The intraperitoneal infusion of male bone marrow cells to the "op" female Rat reverses the course of the lethal disease and initiates a repopulation of the thymus, spleen and bone marrow. The weight of the atrophic "op" thymus increases before any sign of recovery becomes apparent.
In the "op" rat congenital osteopetrosis is a lethal condition. The management of this disease can be achieved by a single injection of a marrow cell suspension from a normal donor or by temporary parabiosis with a normal Rat, the latter procedure being less efficient than the former according to kinetic, roentgenographical and histological examinations.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.