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M L Lippmann

Publications and source records attributed to M L Lippmann.

23 records · Page 2Linked to original sources

Is pulmonary artery catheterization necessary for the diagnosis of pulmonary edema?

The ability to differentiate cardiac from permeability edema on the basis of clinical and radiographic criteria was studied in 70 ICU patients in whom subsequent pulmonary artery catheterization (PAC) was performed. Our study demonstrated that the clinical assessment of permeability pulmonary edema was correct in 17 of 20 patients (85%). In contrast, of the 50 patients initially suspected of having cardiac edema, only 31 (62%) were predicted correctly (p less than 0.05). Complications relating to catheterization occurred in 25% of patients, with 3 deaths. We conclude that the diagnosis of cardiogenic pulmonary edema, based on clinical criteria alone, is often inaccurate in the intensive care setting. The failure of patients to respond to initial therapy should mandate pulmonary artery catheterization, despite the attendant risks. Furthermore, even though the clinical diagnosis is correct in 85% of patients with permeability pulmonary edema, PAC data may be necessary for optimal management.

Aged↗

Cardiopulmonary effects of acute thallium poisoning.

Gastrointestinal distress and alopecia are the most commonly reported symptoms of acute thallium intoxication; however, cardiac and pulmonary disease may dominate the acute stages of the disease. We report four cases which illustrate the importance of cardiac and respiratory disease in this syndrome.

Acute Disease↗

Plasma and serum concentrations of DNA in pulmonary thromboembolism.

The value of circulating DNA concentrations in the diagnosis of pulmonary embolism (PE) was assessed in 68 consecutive patients, of which 36 (Group 1) had clinical symptoms suggesting PE. The diagnosis of PE was established in 13 patients on the basis of pulmonary angiography (PA) (8 patients) and high probability ventilation-perfusion lung scanning (VPS) (5 patients). Pulmonary embolism was ruled out in 23 patients (by PA, 9 patients; by VPS, 14 patients). We found abnormally high DNA concentrations in 26 of the 36 patients (72%) with suggested PE, but there was no significant differences between patients with and patients without PE (p less than 0.05). The results were compared with the DNA concentrations in the remaining 32 patients (16 medical and 16 surgical cases) who had no clinical evidence of PE (Group 2). Increased DNA concentrations were found in 21 of these (66%). There was no significant difference in mean DNA concentrations between Group 1 and Group 2 (p less than 0.05). We conclude that pulmonary angiography and high probability ventilation-perfusion scanning remain the most reliable methods for the diagnosis of PE.

Adrenal Cortex Hormones↗