Biomedical subjects
M L Loren
Publications and source records attributed to M L Loren.
Vascular ring presenting as asthma: the value of a flow-volume curve.
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Oral challenges in inhalant antigens in asthmatics.
Nine asthmatic children were sensitive to a variety of antigens by skin testing and bronchial inhalation challenges. On two separate occasions they received the antigens sublingually at 2.5 to 50 times the dose received by bronchial challenge. There were no subjective symptoms or objective changes in pulmonary function measurements following the oral challenges.
Irreversibility of obstructive changes in severe asthma in childhood.
The findings in three children with severe asthma are presented. Following intensive round-the-clock therapy with theophylline (the dosage of which maintained serum levels of theophylline between 10 microgram/ml and 20 microgram/ml) and therapy with prednisone (20 mg twice daily for three weeks or more), there were improvements in spirometric and body plethysmographic measurements. Despite this therapy, abnormalities in the forced expiratory volume in one second, the maximal midexpiratory flow, the residual volume, and specific airway conductance remained. These cases represent a subgroup of asthmatic children with reactive airways who have an irreversible component to their disease.
Age of onset in a group of severely asthmatic children.
The age of onset was examined retrospectively in a group of severely asthmatic children. The mean age of onset for males was 29.4 +/- 22.7 months and 30.4 +/- 27.0 months for females. The distribution of age of onset between males and females was remarkably similar (X2 = 1.77, 0.6 less than p less than 0.9). The mean age of onset was similar in children not receiving corticosteroids compared to those children who were taking high and low dose corticosteroids. An early or late age of onset appeared independent of corticosteroid requirements. Children with five or more positive immediate skin tests had earlier age of onset and higher total serum IgE levels than those with four or fewer positive skin tests.
Pulmonary sequelae in low-birth-weight infants.
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