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Biomedical subjects

M L Mehrotra

Publications and source records attributed to M L Mehrotra.

At least 19 recordsLinked to original sources
PubMed1992

Mast cell reactivity in lymphoma: a preliminary communication.

Fifty nodes of Hodgkin's disease, 50 of non-Hodgkin's lymphoma and 20 of reactive hyperplasia revealed varying degree of mast cell reactivity. It was maximum in reactive lymph nodes, sinuses and interfollicular areas being infiltrated more than zones. The number of mast cells was more in nodular sclerosis variety of Hodgkin's disease than other Rye-subtypes, and more in Hodgkin's group than non-Hodgkin's, out of the latter, the diffuse histiocytic lymphoma revealed higher number. Analysis of a larger series and follow-up of these patients are indicated to establish the possible reactionary nature of mast cell reactivity in lymphomas, and the prognostic bearing, if any.

Castleman Disease↗
PubMed1990

A study of aluminum phosphide (AlP) poisoning with special reference to electrocardiographic changes.

Ninety patients with aluminum phosphide poisoning have been studied over a period of 3 years. Epigastric pain and vomiting were the common initial clinical features, followed 12 to 24 hours later by cardiogenic shock, oliguria, altered mental state and respiratory distress. Death occurred within 24 to 72 hours presumably due to poison-induced toxic chemical myocarditis as reflected by electrocardiographic changes. The overall mortality was 63.3%. Intravenous magnesium sulphate, probably due to its membrane stabilizing action, appears to be related to the reduction in mortality from 90% to 52% in the latter 62 cases.

Adolescent↗
PubMed1987

A prospective study of BCG given to young children in Agra, India--a region of high contact with environmental mycobacteria.

A multiple skin test survey of school children (aged 5-15 years) living in Agra, India showed very high levels of sensitisation to numerous species of mycobacteria and little difference in tuberculin positivity between those with and without BCG scars. A total of 136 children aged 3 months to 8 years, living in Agra, were skin tested with Tuberculin and Leprosin A and examined for scars of previous BCG vaccination. Of those who had not previously received BCG and who had responses to Tuberculin of zero or less than 5 mm induration, 109 were offered BCG vaccination: 107 accepted and as many of them as possible were followed up with repeat skin testing 1 and 2 years later. The results are discussed in relation to the background of environmental sensitisation. A comparison is made with the data obtained from other places, particularly the Lebanon, where there is little sensitisation from the environment. Although the high level of Tuberculin conversion achieved after BCG suggested that the vaccine might have an important protective effect, the large size of Tuberculin responses in comparison with those obtained in the UK was worrying. Evidence was obtained suggesting that sensitisation to mycobacteria may occur in very young children which is not detected by the Tuberculin test, but which influences responses to BCG vaccination.

BCG Vaccine↗
PubMed1986

Fulminant amebic colitis.

Nine patients with fulminating amebic colitis who were treated surgically from 1975 to 1982 are presented. Only those who had bowel resections with exteriorization of the cut ends survived. The pertinent literature is reviewed briefly.

Adolescent↗
PubMed1978

Host response and tumour biological behaviour in the two histological types of gastric carcinoma.

It appears that there is validity in categorizing gastric carcinoma into two histologic types, intestinal and diffuse. The local host tissue response in 92.5% of cases of the intestinal type of gastric carcinoma was of an exudative nature. Diffuse gastric carcinoma in 70% of cases incited a dense productive fibrosis. Pools of mucin and large number of 'signet-ring' cells were mostly encountered in the intestinal type of carcinoma. Applying Dukes' parameters the tumour was found to be more than three times more invasive in cases of diffuse carcinoma. The prognostic bearing of the two histologic types, different host tissue response, behaviour of the tumour in terms of mucous production and local extension are discussed and it is suggested that diffuse gastric carcinoma carries a worse prognosis than the intestinal type. Study of a larger series of cases and longer follow-up with controlled treatment is essential to confirm this assessment.

Carcinoma↗
PubMed1977

Oesophageal carcinoma in India. Some epidemiologic and morphologic considerations.

Oesophageal carcinoma constituted 2.39% of all malignancies, and 17.11% of gastrointestinal tract malignancies, over a period of 12 years, in Sir Sunder Lal Hospital population in Varanasi. The highest frequency occurred in the sixth decade. The male:female ratio was 2.2:1, this ratio tended to diminish with age. Out of 202 cases the middle third of the oesophagus was involved in 104, the lower third in 72 and the upper third in 26 cases. Although squamous cell carcinoma was by far the most frequent histologic type (193 cases), genuine primary oesophageal adenocarcinoma did occur in 3, and the tumour was completely anaplastic in the remaining 6 cases. The prognostic bearing of certain morphologic features has been discussed. Oesophageal carcinoma is one of the most frequent malignancies of the gastrointestinal tract and a common tumour in elderly Indian men and women.

Adenocarcinoma↗
PubMed1977

Juvenile epithelial malignancy of head and neck.

Children aged 15 years or less usually suffer from mesenchymal malignancies. Observations on four rare cases of juvenile epithelial malignancy in larynx, maxillary antrum, upper lip, and parotid are reported. No particular etiological factor could be found in these cases. Age, as such, had no effect on the clinical presentation of the malignancy, its management and prognosis.

Adolescent↗