PubMed Health⌕ Search

Biomedical subjects

M L Miles

Publications and source records attributed to M L Miles.

13 recordsLinked to original sources
PubMed1990

Skull trepanation among the early Indians of Canada and the United States.

The authors reviewed anthropological reports of skull trepanation (trephination) among the early Indians of Canada and the United States of America. Published reports of 20 trepanations in 19 skulls are reviewed. All were believed to have been performed ante mortem. Most were from the pre-Columbian era. Eleven were from Canada (8 from British Columbia) and 8 from the United States. The location of skull perforation was parietal in 9 cases and less often frontal (3) or occipital (3). The average skull opening was oval or oblong, with a diameter of 3.0 cm. The method of trepanation was probably gradual scraping in most cases. Skull fractures were not present in any case. About 90% of the trepanations showed evidence of healing, indicating survival. The authors discuss the evidence for skull trepanation in the United States and Canada, and compare these findings to the better studied South and Central American material.

Canada↗
PubMed1982

Subplasmalemmal linear density: a mesodermal feature and a diagnostic aid.

Subplasmalemmal linear density (SLD), a surface structure known to occur on mononuclear phagocytes, has been considered a possible morphologic marker of mesenchymal cells or cells of mesodermal origin. A retrospective review of human surgical pathology cases studied in a diagnostic electron microscopy laboratory over a five-year period confirmed that SLDs are primarily seen in cells of mesodermal origin in a variety of neoplastic and nonneoplastic tissues. Therefore, SLD may be of value as a mesodermal marker in evaluating poorly differentiated tumors. Furthermore, the presence or absence of SLD in tissue histiocytes in diverse conditions may contribute to the understanding of heterogeneity among this group of cells.

Carcinoma↗
PubMed1982

Concomitant herpes-monilial esophagitis: case report with ultrastructural study.

Herpesvirus and Candida albicans are each well-known pathogens associated with esophagitis, and concomitant infections by both agents are occasionally observed. The case of a 58-year-old man who had been treated for carcinoma of the tonsil and died of confluent bronchopneumonia is presented. Autopsy revealed an esophagitis in which cytologic changes of viral infection were seen in the intact esophageal epithelium along with pseudomycelia of Candida albicans within the ulcer bed. In addition, ultrastructural study showed dual infection by Candida and herpesvirus within individual esophageal epithelial cells at the ulcer edge, a unique demonstration of coexistent intracellular infection.

Candida albicans↗
PubMed1982

Unusual pericytic proliferation in a meningotheliomatous meningioma: an ultrastructural study.

Hemangiopericytomas are controversial tumors of the central nervous system and are regarded by many neuropathologists as variants of meningioma. A unique vascular change which may have bearing on this relationship was encountered in a sphenoid wing meningioma in a 93-year-old man. By light and electron microscopy, the tumor showed classical features of a meningotheliomatous meningioma. In addition, however, there was striking proliferation of small dark cells within vessel walls, extending into the parenchyma, and often dominating the picture. Ultrastructurally, the small cells, in contrast to the meningothelial cells, were totally invested by basal laminae, showed extensive pinocytosis, and subplasmalemmal condensations, i.e., pericytic features. The two cell populations, although intimately intermingled, maintained distinct features. This case may represent an expression of divergent mesodermal differentiation of meningeal cells, either as a unique vascular reactive change or alternatively as an early stage in the development of a hemangiopericytic tumor of the meninges.

Aged↗
PubMed1980

Blastomycoma of the cerebellum. An ultrastructural study.

Biopsy tissue from a cerebellar blastomycoma in a 48-year-old man was studied by electron microscopy. The fine structure of the fungi recapitulated that of the yeast forms described in cultures and culture implants. Mycelial forms were not encountered. The yeasts displayed lamellated cell walls and occasional multinucleation. Persistent broad-based budding with complex membranous profiles related to the cell membrane was prominent. The organisms were found within multinucleated giant cells and macrophages which exhibited subplasmalemmal linear densities and occasional desmosomal junctions.

Biopsy↗
PubMed1980

Ultrastructural study of a cerebral toruloma.

Biopsy tissue from a human cerebral toruloma was studied ultrastructurally. Numerous yeasts were found within extracellular space and within macrophages or epithelioid cells and demonstrated a prominent mucopolysaccharide capsule. Extensive vacuolization of yeast-bearing macrophages was demonstrated. Coating material lined these vacuoles as well as the surface of these cells where numerous contacts with lymphocytes were observed. The macrophages further displayed prominent subplasmalemmal linear densities, structures common to epithelioid cells in granulomatous diseases as well as a variety of cells of presumed mesodermal origin.

Adult↗
PubMed1980

Glioblastoma multiforme occurring 13 years after treatment of a medulloblastoma.

Although medulloblastoma is said to be capable of astrocytic differentiation, the development of an astrocytic neoplasm in association with a medulloblastoma is extremely rare. We report the light and electron microscopic features of a supratentorial glioblastoma that occurred 13 years after radiation therapy for a cerebellar medulloblastoma. The diverse ultrastructural features of the glioblastoma may reflect the multipotentiality of the cells in medulloblastoma. An alternate interpretation is that the glioblastoma represents a radiation-induced neoplasm after therapy for a medulloblastoma.

Adolescent↗
PubMed1976

Eosinophilic granular ceels in oligodendrogliomas. An ultrastructural study.

In three cases of oligodendrogliomas, atypical cells rich in eosinophilic cytoplasm, resembling plump astroyctic or astroblastic cells, were studied under the electron microscopy. These cells showed finely granular cytoplasm with routine hematoxylin-eosin preparation; ultrastructurally, they exhibited abundant, round cytoplasmic bodies of autophagic-vacuole type, in addition to other fine structures characteristic of oligodendroglioma cells.

Astrocytes↗
PubMedDate not supplied

The coexistence of ribosome-lamella complex and annulate lamellae in chronic lymphocytic leukemia.

An electron microscopic study of peripheral blood and lymph node from a patient with chronic lymphocytic leukemia revealed ribosome-lamella complexes in 11-16% of the peripheral lymphocytes and in 14% of the nodal lymphocytes. Annulate lamellae were seen in 2-8% of the peripheral lymphocytes and in 8% of the nodal lymphocytes. One peripheral blood specimen revealed coexistence annulate lamellae and ribosome-lamella complexes within the same cells in an additional 4% of the lymphocytes. The two structures were connected by continuous strands of apparent endoplasmic reticulum. Although annulate lamellae and ribosome-lamella complex have each been described in chronic lymphocytic leukemia, albeit uncommonly, their unusual association with one another has not previously been documented and might offer a clue as to the origin and role of these interesting structure. The possible ramifications of these observations include relationship of the structures to endoplasmic reticulum and protein synthesis, to in vitro and possible clinical induction by drugs including "antitubulins," and to induction in vitro by viral infection.

Endoplasmic Reticulum↗
PubMedDate not supplied

An electron microscopic study of central nervous system sarcoidosis.

Although the fine structure of extraneural sarcoidosis is well documented, ultrastructural study of central nervous system (CNS) sarcoidosis has been limited. Electron microscopic (EM) examination of 3 biopsy cases of CNS sarcoid revealed a mixed cellular population of lymphocytes, epitheloid cells, and multinucleated giant cells. The epitheloid and multinucleated giant cells shared common ultrastructural features of nuclei and cytoplasm. In addition, they displayed similar specializations of the cell surface, including subplasmalemmal linear densities (SLD) and villous projections. These findings recapitulate those described in extraneural sarcoidosis and other granulomatous disorders. This supports the contention that the macrophages or epitheloid cells present in CNS lesions are derived from the same mononuclear phagocytic system as their systemic counterparts.

Adult↗
PubMedDate not supplied

Intracerebral Ganglioneuroblastoma with intracytoplasmic microtubular aggregates: case report and ultrastructural study.

Cerebral ganglioneuroblastoma is a rare entity that is not well characterized at the ultrastructural level. We report a case of such a neoplasm with some unique fine structural features. The tumor contains both small cells with little evidence of differentiation and large, bizarre multinucleate cells, many of which contain intracytoplasmic aggregates of 22- to 24-nm microtubules that displace the nucleus and cytoplasmic organelles to the periphery of the cell. Inclusions of this type have of previously been described in this entity.

Adult↗