Dynamic concepts for neonatal education: developing a combined medical and nursing education program.
Explore the source record for details and available documents.
Arizona↗
Biomedical subjects
M L Shwer
Publications and source records attributed to M L Shwer.
Absence of bilirubin binding competitors during phototherapy for neonatal jaundice.
Bilirubin-albumin binding was quantitated (peroxidase method) before, during, and after phototherapy in 21 jaundiced infants. Binding was analyzed at two different serum dilutions (1:1.8 and 1:57) to determine whether binding competitors are present during phototherapy. No significant changes in binding were found at either dilution during phototherapy, regardless of birthweight, gestational age, or illness. Serum binding of bilirubin does not appear to be altered during phototherapy.
Bilirubin↗
Bilirubin-albumin binding in neonatal salicylate intoxication.
Impaired bilirubin-albumin binding (peroxidase method) was found in serum from a salicylate-toxic neonate. Bilirubin binding improved with serum dilution, indicating weak, competitive salicylate binding. The competitive effect of salicylate was much less than expected from calculations using data from the literature. This occurs because salicylate displaces bilirubin only from the primary bilirubin binding site, and the displaced bilirubin is buffered by secondary bilirubin binding sites. Binding data for salicylate and bilirubin are used to derive guidelines for the clinical management of jaundice in the salicylate-toxic neonate.
Bilirubin↗