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Biomedical subjects

M L Sonnet

Publications and source records attributed to M L Sonnet.

7 recordsLinked to original sources
PubMed1993

[Early somatosensory (SEP) and auditory (AEP) evoked potentials in anoxic coma: prognostic value].

Early somatosensory (SEP) and auditory (BAEP) evoked potentials, when recorded within the first seven days of the course of anoxic coma, appear to be reliable to evaluate anoxic ischemic cortical or under-cortical lesions. Prognosis depends especially on cortical SEP (N20-P25): the lack of SEP is a good outcome predictor of death (abnormal BAEP) or of vegetative status (normal BAEP); the presence of normal and bilateral cortical SEP (with normal BAEP) allows to predict awakening, without prejudging of neurologic sequelae, even if they are severe.

Acoustic Stimulation↗
PubMed1991

[Neurological manifestations in the vertebro-basilar system suggesting pregnancy toxemia].

Early CT scan showed a large hypodensity throughout midbrain. Brainstem auditory evoked potential showed initially an abolition of III and V pikes suggesting brainstem injury. Two days later neurologic examination and brain stem auditory evoked potential returned to normal. CT scan performed three weeks after the onset was normal. These finding suggest a vasospasm; in this case betasympathomimetic agents given two weeks before the onset of toxemia for preterm labor could lead to the vasospasm.

Adult↗
PubMed1991

[Neurologic manifestations in the vertebro-basilar system revealing pregnancy toxemia].

We report a case with focal neurological deficits suggesting vertebro-basilar system ischemia, in the course of pre-eclampsia. An early CT scan showed a large hypodensity throughout the midbrain. Brainstem auditory evoked potentials initially showed an abolition of III and V pikes suggesting brainstem injury. Two days later both neurological examination and brain stem auditory evoked potentials returned to normal. A CT scan performed three weeks after the onset was normal. These findings suggest a vasospasm which may have been due to sympathomimetic agents given two weeks before the onset of toxemia for preterm labor.

Adult↗
PubMed1990

[Early somatosensory and auditory evoked potentials in anoxic coma. Role in evaluating and prognostic value].

Early somatosensory (ESEP) and auditory (EAEP) evoked potentials were recorded in 27 patients with severe coma (Glasgow score less than 5) following cardiorespiratory arrest, within the first 7 days of its course. Somatosensory responses were elicited by stimulation of the median nerve. ESEP were abolished in 17 patients due to a parietal thalamo-cortical lesion. Among these, 6 patients died within one month and 11 presented with a persistent vegetative state. In all patients EAEP were obtained, showing functional brainstem activity. Low-voltage EAEP, especially for peak V (inferior colliculus or upper part of the brainstem), was sometimes observed. One patient, in whom ESEP and EAEP were initially abolished, died rapidly. In 9 other patients scalp-recorded ESEP and EAEP were normal; all emerged from coma including 5 with good neurological recovery and 4 with neurological sequelae. Clinical, electroencephalographic and computerized tomographic data appeared to be devoid of predictive value at the same initial period. In view of their sensitivity to anoxia and to cerebral oedema, even with neurosedative drugs, ESEP seemed to be reliable in predicting outcomes and in evaluating central nervous system lesions at cortical and subcortical levels (basal ganglia and brainstem) after cardiorespiratory arrest.

Adolescent↗
PubMed1987

[Evoked potentials in comatose children].

Auditory and somatosensory EPS obtained after median nerve stimulation are an interesting approach for the central nervous system investigation. However, there are some problems of interpretation during the first year of life, related to the maturation of the nervous system. We studied 20 severely comatose children aged 8 months to 15 years, admitted in an intensive care unit. Most of them were intubated, mechanically ventilated and received high doses of barbiturates. Coma was related to severe head injury, meningitis, encephalitis, Reye syndrome, malignant hyperthermia, cerebral lymphoma. Normal EP are correlated with a good recovery. Patients with abnormal EP may die or exhibit neurological sequelae. The absence of somatosensory EP is correlated with a bad outcome and is generally related to cerebral oedema. Appreciation of the prognosis in comatose children may be improved by repeated determination of auditory and somatosensory EP.

Adolescent↗
PubMed1983

[Neurophysiologic study of 2 cases of hemianesthesia as a result of subcortical lesions. Results of recording far-field somatosensory evoked potentials].

The volume-conducted responses of the lemniscal pathways to median nerve stimulation at wrist may be recorded on the scalp (far-field potentials). These positive far-field SEPs components are widely distributed on the scalp and their peaking latencies vary between 9 and 15 milliseconds. In normal adults a maximum of 4 far-field potentials (P9, P11, P13 and P14) may be individualized; two of them (P9 and P14) are constant. These SEPs were studied in two patients with lateralized somatosensory loss; one with a cervico-medullary traumatic lesion, the other with a thalamic infarct. These observations allow the following conclusions 1) the P9 component takes origin in the proximal part of the brachial plexus roots; 2) the P14 potential has a brainstem origin; 3) the contralateral N20 potential is generated in (or close to) the primary somato-sensory cortex (SI). Thus it is possible with a single channel to record the activity of the somatosensory pathways from dorsal roots up the parietal cortex.

Adult↗