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Biomedical subjects

M L Wisbey

Publications and source records attributed to M L Wisbey.

9 recordsLinked to original sources
PubMed1982

Milk 99Tcm-EHIDA test for enterogastric bile reflux.

The study and clinical assessment of enterogastric bile reflux has been restricted for want of a simple non-invasive test for its detection and quantification. This paper describes such a test in which biliary excretion scintigraphy has been combined and a mild meal provocation. Two of 10 healthy volunteers studied showed probable reflux of approximately 5 per cent of total initial abdominal field activity. Among 73 patients studied, 37 patients showed definite reflux of up to 47 per cent. Reflux occurred in 19 of 22 post-gastric surgery patients and in 7 of 22 patients with peptic ulcer disease, gastritis or gastro-oesophageal reflux. None of 7 patients with 'non-specific' abdominal pain showed any reflux, but 11 of 22 patients with gallstone disease or previous cholecystectomy showed reflux of up to 35 per cent, including 9 of 11 patients with loss of gallbladder reservoir function.

Adult↗
PubMed1981

The place of hepatobiliary isotope scanning in the diagnosis of gallbladder disease.

The present trend towards a more aggressive operative policy in acute cholecystitis has led to a search for more accurate methods of diagnosis. A possible contender in this field is hepatobiliary isotope scanning. Ninety-nine patients with right-sided upper abdominal pain were studied after the intravenous injection of 99Tcm-pyridoxylideneglutamate. In addition, contrast radiology was performed in 87 of these. Subsequently 23 were shown to have acute cholecystitis, 45 to have other gallbladder disease and 31 to have no evidence of cholecystic pathology. Isotope scanning was found to be reliable when negative at excluding acute cholecystitis (predictive value 100 per cent) and when positive at confirming gallbladder disease (predictive value 100 per cent). In these respects it compared favourably with contrast radiology (corresponding predictive values 80 per cent and 94 per cent) but was greatly inferior for the exclusion of cholelithiasis. A practical method of scanning for routine clinical use is outlined and it is suggested that the method may be clinically useful as a first investigation in those patients presenting with acute right-sided upper abdominal pain. It may also be helpful in confirming pathology in a nonfunctioning gallbladder on oral cholecystography. When the isotope scan is negative (normal) contrast radiology is still required to exclude cholelithiasis. By a combination of the two techniques the correct diagnosis was arrived at in each of the 99 patients studied, suggesting that the methods may have complementary roles.

Acute Disease↗
PubMed1981

Scintiscanning of the breast with 99Tcm-diethylene triamine penta-acetic acid--a prospective blind evaluation.

In this blind prospective study of breast scintiscanning with 99Tcm-diethylene triamine penta-acetic acid (DTPA) in 67 female patients presenting at a primary breast referral clinic, we have observed that this investigation has a high diagnostic accuracy in distinguishing benign from malignant lesions of the breast. The predictive value of the test when positive in establishing the presence of cancer is 94 per cent with a false negative rate of 6 per cent. The predictive value of the test when negative in excluding cancer in 97 per cent with a false positive rate of 3 per cent. Initial studies also indicate the potential value of DTPA breast scintiscanning in delineating the activity of painful benign lesions of the breast.

Adult↗
PubMed1980

Diagnosis of intestinal duplication by 99Tcm-pertechnetate scanning.

A case is described of a 19-month-old boy who presented with melaena. Intestinal duplication was diagnosed by 99Tcm-pertechnetate scanning and was confirmed at operation 2 years later, when the child was admitted with intestinal perforation. The technique is a reliable, non-invasive method for diagnosing ectopic gastric mucosa and is recommended in all cases of unexplained rectal bleeding in children.

Choristoma↗
PubMed1976

Prediction of human spleen size by computer analysis of splenic scintigrams.

A method of assessing spleen size from splenic scintigraphs obtained using autologous heat damaged 99Tcm labelled red cells is described. The method depends on a "computed volume" estimate. The method has a correlation coefficient of 989 with the exsanguinated weight ofthe spleen after splenectomy and has been shown to have an accuracysuperior to methods previously described.

Computers↗
PubMed1975

Uptake of a colloid in rat liver following intravenous intrasplenic and intramesenteric injection.

Intramesenteric and intrasplenic injections of 99mTc-sulfur colloid in the rat resulted in significant differences between the mean uptakes in only some of the liver lobes. More important were the wider interlobular variations seen in the intrasplenic and intramesenteric routes of injection compared with the intravenous route. It is suggested that these differences result from laminar blood flow in the portal vein. In the light of our findings, previous evidence must be considered inconclusive. Laminar flow appears to vary between individual animals and may also vary from time to time in the same animal. Caution is therefore advised when other than systemic routes of injection are used.

Animals↗
PubMed1975

In vivo assessment of liver size in the rat.

In vivo assessment of liver mass in the rat was achieved using several parameters obtained by scintigraphy, including one computed using a Nuclear Data 50:50 analysis system. All correlated well with the directly measured liver weight. The simplest parameter, the area of the anterior view measured from the Polaroid scintigraph, was therefore the one preferred. The results so obtained were compared with those derived from the relationship between liver and body weights. It is suggested that this accurate in vivo measurement of liver mass is of value in the study of the pathophysiology of this organ.

Animals↗