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M López-Gómez

Publications and source records attributed to M López-Gómez.

At least 19 recordsLinked to original sources
PubMed2005

Sleep disturbances, socioeconomic status, and seizure control as main predictors of quality of life in epilepsy.

Improving quality of life is the most important goal for patients with epilepsy. To recognize the factors associated with quality of life in patients with epilepsy in Mexico, we performed a cross-sectional survey using the Quality of Life in Epilepsy 31 (QOLIE-31) inventory to assess the quality of life of 401 adult patients with epilepsy at the National Institute of Neurology and Neurosurgery of Mexico. Clinical and demographical data were collected. Multiple regression was used to determine which factors affected quality of life in our patients. The variables that most strongly predicted a lower QOLIE-31 total score after multiple regression were sleep disorders (P<0.001), socioeconomic status (P<0.001), female gender (P=0.002), and high seizure frequency (P=0.001). In our study, neither depression nor time of evolution of epilepsy had significant influence on QOLIE-31 scores.

Adult↗
PubMed1997

Nontyphoidal salmonella intracranial infections in HIV-infected patients.

Salmonella focal intracranial infections are unusual in human immunodeficiency virus (HIV)-infected patients. Six such infections have been reported in the world literature. We report a case of salmonella subdural and epidural cerebral empyema with concomitant osteomyelitis of the frontal bone. Such a complication in the course of salmonellosis is reported for the first time. In previously published case reports, four patients had brain abscess and two had subdural empyema. Salmonella typhimurium was isolated from two patients, and different serotypes were recovered from the others. All patients had advanced HIV disease, and all but two had had opportunistic infections before the diagnosis of salmonella intracranial infection. Surgical drainage combined with systemic antibiotic therapy resulted in the recovery of four of five patients. No regression of the lesions occurred in one patient treated only with antibiotics for multiple cerebral abscesses.

AIDS-Related Opportunistic Infections↗
PubMed1995

[Proliferation of large granular lymphocytes in patients with systemic lupus erythematosus].

BACKGROUND: Large granular T lymphocytes (LGL) make up a small portion of cellular population in peripheral blood. An abnormal proliferation of LGL is detected together with cytopenic and other autoimmune disorders and is often associated with rheumatoid arthritis. The association with other autoimmune diseases, such as systemic lupus erythematosus, is poorly known. The clinical and immunological profile in five patients with SLE and LGL proliferation is here reported. MATERIALS AND METHODS: A clinical follow-up and prospective phenotypic study of mononuclear cells was conducted in patients with SLE for a period of 24 months. LGL were identified on the basis of their shape and analyzed by flow cytometry as cells coexpressing thymic differentiation antigens (CD3 and CD4, or CD8) and NK cells CD16, CD56 or CD57). RESULTS: Five out of 43 patients with SLE showed recurrent proliferations of LGL (from 2 to 4 per patient) chronologically associated with lupus exacerbations. LGL represented 52 to 78% (mean +/- SD = 56 +/- 8%) from the total of lymphocytes. The phenotype in proliferations was heterogeneous but it was consistent in later relapses in each patient (patient #1 and #2: CD3+CD8-CD4+CD16+CD56+CD57-HLA/D+ patients #3 and #4: CD3+CD8+CD4-CD16+CD56+CD57-HLA/DR+ patient #5: CD3+CD8+CD4- CD16+CD56+CD57-HLA/DR+patient 5:CD3+CD8+CD4-CD16 +/- CD56-CD57+HLA/DR+). These five patients had long term SLE with a greater number of exacerbations and a tendency to develop hemocytopenias, requiring high doses of corticosteroids and even immunosuppressors to control their condition. CONCLUSIONS: Some patients with SLE develop LGL proliferations. The activity, clinical severity and hematological involvement seem to be associated with this immunological disorder, but the pathogenic significance and prognosis of these proliferations are still to be elucidated.

Adult↗