[Study of an epidemic of lymphocytic meningitis due to Echo 30 virus].
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Adolescent↗
Biomedical subjects
M Lab
Publications and source records attributed to M Lab.
[Biology of papillomavirus infections. I. General characteristics].
Papillomaviruses are pathogens which induce cutaneous and mucosal lesions in man and in many animal species. The characterization of these viruses was rather low, because viral infection cannot be fully reproduced in cell culture. The development of molecular biology techniques in the 1970s permitted to establish the remarkable plurality of the viruses, the tissue specificity and pecular pathogenicity linked to the type. Studies of the genome organization, the gene expression regulation and the protein characterization gave many informations leading to understand the mechanisms of viral-related carcinogenesis, especially the role of HPV16, the major risk factor for the development of squamous cervical carcinoma.
Genome, Viral↗
[Biology of papillomavirus II infections. Their role in the carcinogenesis of the cervix].
The association of human papillomaviruses (HPV), i.e., papillomavirus type 16, with cervical dysplasias and carcinomas is now well established. Additional agents such as sexual behaviour, immunity deficiency, sociodemographic factors, microbiological agents..., are however implicated in the multistage progression from viral infection to cancer. And inactivation of tumor suppressor gene products (p53, p105Rb), oncogene activation (c-myc, c-ras), aneuploidy, karyotypic abnormalities are key events in the tumor progression. Numerous aspects of the biology of human papillomavirus, i.e. natural history, epidemiology, nature and mechanisms of the immune response are under active investigation. Screening strategies of HPV infections (cytology, HPV DNA detection and HPV antibody detection) demonstrated their efficacy in many countries, while prophylaxy and treatment of these infections by vaccines are still under development.
Cell Transformation, Neoplastic↗