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Biomedical subjects

M Labib

Publications and source records attributed to M Labib.

27 records · Page 2Linked to original sources

Bone disease in chronic alcoholism: the value of plasma osteocalcin measurement.

Osteoporosis is more common in chronic alcoholics than in age-matched controls. Possible aetiological factors are: malabsorption of calcium and vitamin D; liver disease and abnormal parathyroid function. The possibility that alcohol may directly affect osteoblastic function has, however, received little attention. We measured plasma osteocalcin, a protein synthesised specifically by osteoblasts, in chronic alcoholics. Our data show that these have low plasma osteocalcin but normal calcium, magnesium and parathormone, which suggest that alcohol may be directly toxic to osteoblasts.

Adult↗

Impaired renal tubular function in chronic alcoholics.

Despite the well known effects of chronic alcohol abuse on the gastrointestinal, cardiovascular, nervous and endocrine systems, little information is available on its effect on renal function. To assess renal function we measured urinary excretion of albumin, alpha 1 microglobulin and retinol binding protein in 30 chronic alcoholic patients. Our data shows that 40% of chronic alcoholic patients have impaired renal tubular function.

Adult↗

Biochemical studies of some non conventional sources of protein. Part 4. The proteins of mango waste stone kernels.

The gross chemical composition, protein content and amino acid composition of mango stone kernels of four Egyptian varieties (Ewsi, Hendi, Fonso and Timour) were investigated. Carbohydrates are the main components of the seed. The protein content varies between 5.0 and 7.2% and the ether extract ranged from 10.8% to 13.6%. High glutamic acid, aspartic acid and leucine content and low concentration of sulfur-containing amino acids are characteristic for the proteins of mango kernels. Lysine level is also low, the concentration of other essential amino acids is acceptable. Sulfur-containing amino acids are the first limiting ones followed by lysine and threonine.

Amino Acids↗

Hypophosphataemic osteomalacia and alcoholism: a possible link.

Sporadic adult-onset hypophosphataemic osteomalacia is rare and its pathogenesis is unknown. A renal tubular defect, acquired on a toxic basis, has been proposed as the mechanism. Recent evidence suggests that alcohol can cause renal tubular damage. The history and stigmata of alcohol abuse in the present case implicate alcohol as the most likely cause of this patient's hypophosphataemic osteomalacia.

Adult↗

Post-traumatic diabetes insipidus combined with primary polydipsia.

We describe a case of diabetes insipidus after head injury in which thirst persisted despite treatment with DDAVP and normal plasma osmolality. Symptoms were only completely relieved when plasma osmolality was below 270 mosmol/kg. We believe that this might have been due to hypothalamic injury causing resetting of the thirst osmostat. To our knowledge, this type of primary polydipsia has not been described before in association with diabetes insipidus following head injury.

Adult↗