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Biomedical subjects

M Lachowicz

Publications and source records attributed to M Lachowicz.

5 recordsLinked to original sources
PubMed2001

Assessment of the ability of mononuclear blood cells to produce IFN-gamma in patients with laryngeal cancer.

The ability of mononuclear blood cells (PBMC), derived from patients with cancer of the larynx, to produce IFN-gamma in vitro was assessed in this paper. Thirty patients (27 male, 3 female) were qualified to the study. Their mean age was 65 (range: 41 to 78 years), tumour sizes found in the group were from T2 to T4, levels of pathologic malignancy G2 or G3. The percentage rates different blood cells phenotypes (CD3+, CD3+ HLADR+, CD4+, CD8+, CD14+ HLADR+, CD19+, CD56+) were evaluated by means of flow cytometry (Coulter EPICS XL). The control group consisted of 20 healthy blood donors. PBMC were derived by centrifugation of heparinized venous blood on Lymphoprep gradient according to Boyum method. Double cell cultures were performed for 24 hours with antibody anti-CD3 or recombinant interleukins 12 (rhIL-12) or 18 (rhIL-18). The statistic analysis was based on Student t and Mann-Whitney's test with significancy at p<0.05. A significant decrease in the production of IFN-gamma by PBMC in patients with laryngeal cancer after stimulation with antiCD3 (p=0.018), rhIL-12 (p=0.027), rhIL-18 (p=0.016) was found in comparison with the controls. The results suggest a decreased production of IFN-gamma in patients with cancer of the larynx.

Adjuvants, Immunologic↗
PubMed2000

[Teenage secondary school students' knowledge of neoplasmatic process].

People's style of lives, their diet and smoking and alcohol intaking are estimated to be cause of 80% of all malignant neoplasms. 736 secondary school students fulfilled a survey to assess their knowledge of neoplasmatic disease. The group was divided in two subsets. The first one were teenagers without a neoplasm in their family (511--69.4%), the other were with a neoplasmatic disease in the family (225--30.6%). The second group had the more complex knowledge of neoplasms. About 6% prefer other than conventional methods of cancer treatment. 1.5% find a neoplasm as an infectious disease. 20% of the teenagers do not know any possibilities of neoplasm prevention.

Adolescent↗
PubMed1998

[Otoneurologic state estimation 2 years after tick-borne encephalitis].

In this paper an attempt is described to estimate the incidence and frequency of neurologic and otologic symptoms among patients two years after TBE. We examined 43 persons of both sexes aged 17-58. The most frequent complaints were: headache--34.9%, equilibrium problems--37.2%, buzzing in the ears--27.9%, hearing problems--23.3%, memory problems--25.6%. Decrease of throat reflexes was stated in 3 (7%) and pseudobulbaris symptoms in 2 (4.6%), weakness of muscles in 4 (9.3%). In audiometric examination decrease of hearing was stated in 8 persons (18.5%). We registered nystagmus: spontaneous--4.6-7%, gaze--13.9-18.6%, positional-T, mainly Nylen I and III type-18.6-25.6%. Pathologic recording in the eye-tracking pattern test was shown in 7 (16.3%) persons. Asymmetry of optokinetic nystagmus was stated in 6 (13.9%) examined persons. Asymmetry in caloric test was proved in 25.5% of examined persons.

Adolescent↗
PubMed1975

Comparative serologic analysis of Lac+ recombinants of serotypes 2a, 2b, 5a and variant Y of Shigella flexneri.

The serologic structure of Lac+ recombinants of 2a, 2b, 5a and var. Y serotypes of Sh. flexneri was compared. Rec. 2a Lac+, rec. 2b Lac+ and rec. Y Lac+ were shown to be identified, and rec. 5a Lac+ was found to differ from those mentioned in that it was deficient in determinants for 3,4 group antigen complex. Furthermore, the paper discusses the presumable genetic mechanisms of the described variability.

Antibodies, Bacterial↗