Biomedical subjects

M Langlet

Publications and source records attributed to M Langlet.

4 recordsLinked to original sources

PubMed2003

Textured hydroxyapatite interface onto biomedical titanium-based coatings.

Hydroxyapatite (HAP) bioceramic coatings grown onto titanium-nitride (TiN) buffer layers by the aerosol-gel procedure present interfaces with a preferred growth orientation. These coatings were crystallized at 800 degrees C and subsequently etched to ease the study of the interface by Auger electron spectroscopy depth profiling. Ion beam milling was applied to cross-section samples to analyze the interface structures using transmission electron microscopy. At the interface, the HAP crystals showed a <002> orientation. It was shown by Auger electron spectroscopy depth profiling that O atoms diffuse into the nitride interlayer, indicating that the formation of O channels in the HAP structure is the driving force inducing the textured film. The outstanding biocompatible properties of both the materials and properties of their interface suggest that HAP/TiN structures are particularly well suited for endoprosthetic applications.

Coated Materials, Biocompatible↗

PubMed2002

Biological evaluation of aerosol-gel-derived hydroxyapatite coatings with human mesenchymal stem cells.

The bioactive properties of hydroxyapatite (HAP) are evaluated for applications involving the enhancement of biocompatible prostheses by seeding human pluripotent mesenchymal stem cells (MSCs). The in vitro response of human MSCs seeded on aerosol-gel HAP coatings is addressed in this work. The processing of the HAP coatings has been carried out by the aerosol-gel technique using calcium nitrate and triethylphosphate as starting precursors. The characterization of the coatings was carried out by using transmission electron microscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, energy disperse X-ray microanalysis, and surface force microscopy, which confirmed the high performance of the HAP coatings. In vitro tests show that human MSCs adhere to aerosol-gel-derived HAP coatings and show proliferation signals on these surfaces.

Aerosols↗

PubMed2002

Microstructural study of aerosol-gel derived hydroxyapatite coatings.

Highly porous aerosol-gel derived hydroxyapatite (HAP) coatings have been prepared from calcium nitrate and phosphoric acid based sols. Precursor solutions were prepared by filtering the suspension formed during the ultrasonic slurring of the reactants mixture. The coatings deposited on Si wafers were studied after sintering at different temperatures by using Fourier transform infrared spectroscopy, X-ray diffraction, energy disperse microanalysis and scanning electron microscopy. The composition, structure and morphology of the coatings sintered at 650 degrees C were found to fit highly porous HAP. That is considered of great relevance since the deposition parameters are compatible with the processing of bioactive coatings on load bearing metallic substrates.

Aerosols↗

PubMed2001

In vitro bioactivity of aerosol-gel deposited TiO(2) thin coatings.

Bioactive, pure, and Ca- or P-doped TiO(2) thin coatings on Ti metal and Si wafers were prepared by the aerosol-gel technique. The coatings were characterized by X-ray photoelectron spectroscopy, atomic force microscopy, Fourier transform infrared spectroscopy, and scanning electron microscopy. Bioactivity was determined in vitro in a simulated body fluid and was shown to be fully comparable to sol gel-derived TiO(2) coatings prepared by dip-coating. However, the formation rate of carbonate containing apatite decreased with increasing dopant concentration, which was related to changes in chemical composition and topology of the coatings.

Aerosols↗