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M Lannoy

Publications and source records attributed to M Lannoy.

4 recordsLinked to original sources
PubMed1995

[Lessons from the MONICA project].

The authors review the various aspects of the MONICA project (Monitoring of Trends and Determinants in Cardiovascular Diseases) coordinated by the World Health Organization. This study comprises, in a defined geographical or administrative entity, an infarction Registry, two or three population surveys and two or three surveys concerning the treatment of the acute phase of myocardial infarction. It is a ten-year study conducted by 39 collaborative centres in 4 continents. The main hypotheses of this study have not yet been verified, as some centres have not completed the 10 years of infarction recording and/or the last population survey. However, the results collected to date and reported in about ten publications grouping all centres, and more than 500 articles published by various centres, demonstrate the wealth of precious information for clinicians provided by this public health project. For example, the infarction Registry demonstrates marked regional differences in myocardial infarction rates in the population and therefore marked differences in acute coronary bed requirements. The Registry also confirms the higher mortality rates in women and at the end of infarction compared to men. Population surveys can be used to follow the course of the main coronary risk factors and to compare the levels of risk factors in different centres. Regional differences clearly show that a more or less aggressive approach to primary prevention is required. Finally, the presence of an infarction Registry and population surveys allow the elaboration of case-control study protocols, several examples of which are mentioned by the authors. All of these techniques will be able to more clearly define the aetiology of coronary heart disease and, consequently, the reduction of this disease in the population by adequate primary and secondary prevention.

Acute Disease↗
PubMed1993

Twenty-five-year mortality follow-up in the Belgian Bank Study.

Two cohorts of male bank employees aged 40-59 at baseline and free of coronary heart disease were pooled and followed during 25 years for all-cause and coronary mortality. The vital status was known for all 1,227 subjects, but in both banks, 8% of all deaths occurred without any clue to a possible cause. All-cause and coronary mortality were 36.9 and 10.5 per 100 subjects, respectively. In bivariate analysis (adjusting for age), systolic blood pressure, diastolic blood pressure, serum cholesterol and cigarette smoking predicted all-cause mortality. The same variables predicted coronary mortality. Body mass index was neither a predictor of all-cause nor of coronary mortality. In multivariate analysis, age, systolic blood pressure and cigarette smoking predicted independently all-cause mortality whereas the same variables and serum cholesterol predicted coronary mortality. For coronary mortality, the odds ratio (OR) of systolic blood pressure > or = 160 against < 140 mm Hg was 2.68 (95% confidence interval, CI: 1.41-5.08). The OR for subjects with baseline serum cholesterol > or = 260 versus < 260 mg/dl was 1.68 (95% CI: 1.31-2.51). The OR for cigarette smokers versus never smokers was 2.54 (95% CI: 1.39-4.64). Age-adjusted relative risk for all-cause mortality for subjects in the highest versus the lowest quintile of a multiple logistic function was 1.72 whereas for coronary mortality the relative risk was 4.94. These results confirm the long-term predictive power of the three major modifiable coronary risk factors when measured once in middle-aged male subjects.

Adult↗