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Biomedical subjects

M Larmas

Publications and source records attributed to M Larmas.

At least 73 records · Page 4Linked to original sources

Prevalence and location of enamel opacities in children after anti-neoplastic therapy.

The prevalence and location of enamel opacities was recorded in 37 subjects from low-fluoride areas who had received anti-neoplastic therapy and was compared with an equal number of healthy controls. All the patients had received combination chemotherapy for a malignant disease for at least 2 yr early on in their lives. These cases, and especially those with leukemia, had more opacities than the controls, although these opacities were mild in form. The results show that childhood cancer and/or the therapy provided for this can affect the developing dentition, involving all teeth in leukemia cases and the permanent teeth of the mixed dentition period in other cancer diseases.

Abnormalities, Drug-Induced↗

Simple tests for caries susceptibility.

Two major problems dominate today's clinical cariology: although it has been known for centuries that sugar harms teeth this still does not often impinge on personal behaviour; the development of clinical caries is so slow that any snapshot of the present situation does not necessarily predict future caries incidence. Some simple tests have been developed for overcoming these problems in a causally directed diagnostic and therapeutic system of providing dental care. Routine measurement of stimulated salivary flow collected over 5 min objectively reveals the hyposalivation or xerostomic patients and directs them toward careful dental and medical examinations as well as to intensified preventive measures. Measurement of the pH and buffering capacity of the saliva related to a knowledge of the present caries prevalence gives an indication of the caries susceptibility of the patient. A high salivary lactobacillus count reveals in most cases a high frequency of sugar intake (or removable dentures and/or open carious lesions), and a salivary yeast infection is an indicator of reduced salivary flow and removable dentures. Both these microbiological shifts are shown by caries active patients. Using modern dip-slide techniques salivary aciduric lactobacilli and yeasts are easily cultured, and thus the development of new caries lesions may be predicted. Such cultures can also be used in the motivation phases of patient management. These simple tests help the modern dentist to evaluate the risk of future caries development, and to strengthen the motivation in patients to adopt healthy dietary habits.

Adolescent↗

Stimulated salivary flow rate, pH and lactobacillus and yeast concentrations in medicated persons.

Flow rate, pH and lactobacillus and yeast counts of paraffin-stimulated whole saliva were analyzed in an adult population of 463 medicated persons. Of the very large number of drugs only a few groups were found to decrease salivation to such an extent that they can be considered to cause dental harm. Persons using neuroleptics, tricyclic antidepressants or antihypertensives were nevertheless found to produce stimulated saliva at rates significantly lower than unmedicated persons. Age had no influence on the flow rate, but postmenopausal age seems to predispose medicated women to a decrease in salivary flow. Higher microbial counts were found in the medicated men.

Adult↗

The relation of stimulated salivary flow rate and pH to Lactobacillus and yeast concentrations in saliva.

This study demonstrates that the presence of yeast, but not lactobacillus infection, is related to salivary flow rate. Salivary pH is correlated with the primary infection of both lactobacilli and yeasts. The low output of saliva appears to influence the quantity of lactobacilli more than that of yeasts. The flow rate was lower and the presence of yeasts was higher in females than in males.

Adult↗