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Biomedical subjects

M Larregue

Publications and source records attributed to M Larregue.

13 recordsLinked to original sources
PubMed1991

[Diverse aspects of congenital syphilis].

Together with the new rise of recent syphilis in the adult woman, congenital syphilis reappears sporadically in our countries, where prophylactic measures (prenatal serology) are sometimes defeated. It remains much more frequent in developing countries. One should know how to interpret a positive serology in a newborn, as it may only reflect passive transplacental transfer of maternal antibodies. One should on the other hand think of syphilis again when the clinical signs are more or less suggestive, the typical picture not being, by far, the most frequent. In spite of the efficacy of Penicillin G: 50,000 U/kg/day during 10 days, neonatal death rate for congenital syphilis is in the neighbourhood of 10%. Our major effort should therefore be aimed at prevention.

Female↗
PubMed1987

[Contact allergy from cigarette smoking].

Usually, recorded cases of allergic contact dermatitis to tobacco are confined to occupational diseases and involve agricultural workers and those engaged in manufacturing or selling the products, all of whom are in contact with tobacco leaves. We have found three cases of contact dermatitis caused by cigarette smoke, which are not occupational disease. We do not know what offending agent is, but in one case the patient is allergic to perfume and this may be the factor responsible, since she smokes only flavoured cigarettes. In addition, we need to know whether the allergen only appears during combustion and is therefore present only in cigarette smoke.

Adolescent↗
PubMed1979

[A case of Richner-Hanhart syndrome (tyrosinosis with ocular, cutaneous and mental manifestations].

A case of Richner-Hanhart syndrom with tyrosinemia is being reported. The diagnosis was suggested from clinical manifestations of this syndrom : superficial opacities of the cornea in an infant preceeding hyperkeratosis of the palms and soles and mild mental retardation. It has been confirmed by the high levels of blood tyrosine. The introduction of a diet low in tyrosine and alanine has lead to a rapid improvement and finally a complete cure of the ophthalmological and dermatological symptoms. The normal metabolism of tyrosine is recalled as well as the specific metabolic aberration responsable for this syndrom (deficiency of cytosol tyrosine amino-transferase). This case is being compared with those which have been previously reported.

Amino Acid Metabolism, Inborn Errors↗
PubMed1978

[Hypocomplementaemic leucocytoclasic vasculitis. (Mac Duffie's syndrome). One case with bacterial lymphadenitis (author's transl)].

Mac Duffie's syndrome includes a hypocomplementaemic allergic vasculitis with essentially cutaneous and articular manifestations. Its pathogenesis, still incompletely elucidated, involves the precipitation of immune complexes in the walls of the all vessels. The problem remains as to whether the alteration in the complement system is merely a reflection of this formation of immune complexes, or if it is primary, favourising the chronic infections which produce such complexes. The significance of the presence of low molecular weight precipitins reacting with C1g in the serum of a number of patients remains uncertain. The case reported, with its new clinical features, does not provide an answer to these questions but emphasises the possible role of chronic infections in the origin of this syndrome.

Adult↗
PubMed1977

[Esophageal localizations of Darier's disease. Radiological description apropos of 4 cases].

The oesophagic affectation seems very frequent in Darier's disease. The authors have found oesophagic lesions in 4 cases examined. The radiologic aspect of this localization shows an oesophagic border in "post stamp" and a definite irregularity of the fasciculation. This fibroscopic examination shows the presence of keratotic papules similar to the skin lesions of this disease.

Adult↗
PubMed1977

[Acrodermatitis enteropathica; zinc sulfate therapy].

We present the case of two siblings with acrodermatitis enteropathica. Zinc levels were low. Oral administration of 100 mg of zinc sulfate allowed total regression of all signs. When zinc therapy was interrupted, the manifestations reappeared and disappeared again when treatment was resumed. A defect of genetic origin in digestive zinc absorption is suggested. Mohnahan's advocated zinc treatment of acrodermatitis enteropathica in 1973; it is a non-toxic treatment, which is always active and be considered as a diagnostic test.

Acrodermatitis↗
PubMed1975

[Penetrating hyperkeratosis of an amputated limb].

On the stump of amputated limbs, a peculiar hyperkeratotic chronic lesion may be observed. The histological picture of this lesion shows a hyperkeratotic plug perforating the epidermis. In the dermis disorganised keratine lamelles are found. This lesion could be differenciated from Kyrle's disease by the fact that it consists of a single lesion of traumatic origin and by the presence of hypertrophic bundles underlying the hyperkeratosis.

Amputation Stumps↗
PubMedDate not supplied

Collodion baby.

The study of 198 collodion babies, 29 personal cases and 169 from the literature was undertaken. The collodion membrane with spontaneously desquamate between the 15th day and 3rd month of life. During the neonatal period one third of the infants die due to pulmonary complications or infection. The collodion membrane seems to have an increased permeability. The desquamation is followed by a relapse which leads to different keratinization disorders, most frequently nonbullous congenital ichthyosiform erythroderma.

Humans↗