Biomedical subjects
M Lazarides
Publications and source records attributed to M Lazarides.
Delayed femoral artery trauma from migration of a broken wire after total hip replacement.
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Neuropathological examination of the alterations of the intrinsic innervation in multiple sclerosis cystopathy.
Morphometric analysis of the innervation pattern of the stromal layer of the urinary bladder was done on biopsies from 88 patients with definite multiple sclerosis (MS). The biopsies were stained for acetylcholinesterase and for S100 protein, and a semiquantitative score was assigned. Nearly 30% of the samples showed increased immunoreactivity for S100, indicating Schwann cell hyperplasia. In 16% a decreased S100 immunoreactivity was found, the significance of which is unclear. More than 90% had normal acetylcholinesterase activity. No correlation could be demonstrated for age, sex, severity and duration of the disease, the presence of cystitis and type of detrusor dysfunction. The finding of altered S100 immunoreactivity in MS bladders could indicate that MS also affects the peripheral nervous system and is not limited to the central nervous system as classically described. This finding warrants further investigations.
Malignant brachial artery embolism.
We present a rare case of malignant embolization of the brachial artery from a primary pulmonary tumor. The arterial embolism was the initial event in the clinical course of the disease. A review of the literature revealed forty three cases of malignant peripheral arterial embolism reported, and only two similar cases in which the embolization was the initial event of the disease.
Natural history of chronic bilateral internal carotid artery occlusion.
Chronic bilateral ICA occlusion was found in 15 of 3200 patients studied with duplex scanning during a six years period. Ten of these patients had a history of stroke. Mean follow-up was 28.9 months. Six patients died during follow-up, coexisting cardiac ischaemia being the major cause of death. Two patients suffered a stroke (one fatal) resulting in an annual stroke rate of 5.5%, three patients continued to have TIAs and 5 remained asymptomatic. Chronic bilateral ICA occlusion is not always associated with neurological deficit. Coronary ischaemia, more than stroke is the leading cause of death in these patients.