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Biomedical subjects

M Lazzaroni

Publications and source records attributed to M Lazzaroni.

At least 109 records · Page 6Linked to original sources
PubMed1983

Blood levels of cimetidine in patients with liver cirrhosis.

Blood concentrations and pharmacokinetic parameters of cimetidine were studied in 16 patients with liver cirrhosis and in 8 apparently healthy subjects. The drug was administered orally as a single dose of 200 mg. Four patients of both groups were treated with cimetidine orally and intravenously. No statistically significant difference was observed between pharmacokinetic parameters of cimetidine obtained from control subjects and those from patients with liver cirrhosis. The pharmacokinetic parameters of cimetidine in patients with liver cirrhosis did not significantly differ from those of normal patients even if separately calculated with respect to serum albumin and total serum bilirubin.

Cimetidine↗
PubMed1982

The effect of pirenzepine on meal-stimulated gastric acid secretion, gastrin release and gastric emptying.

Pirenzepine is a new antimuscarinic drug with a peculiar affinity for gastric parietal cells' acetylcholine receptors. Previously it has been shown that the drug effectively inhibits both basal and gastric acid secretion stimulated by several secretagogues. The aim of the present work has been to evaluate, in double-blind, placebo controlled, randomized studies on 6 male patients, the effect of pirenzepine (50 mgs orally) on gastric secretion stimulated by peptone meal, gastric emptying and gastrin release. The results show a significant decrease of gastric secretion (48 per cent in the 1st and 30 per cent in the 2nd hour) without any effect on gastric emptying and gastrin release.

Adult↗
PubMed1982

Gastroscopy in elderly patients.

The results of oesophago-gastro-duodenoscopy in 630 consecutive elderly patients, age 65 years or over, were reviewed in order to asses the efficacy, safety and acceptability of the technique in this age group. The study showed that the use of endoscopy is attended by relatively few contra-indications, that considerations restricting its use are also relatively few, and that endoscopy can be invaluable in confirming or refuting the diagnosis of malignancy and in detecting bleeding lesions. It was also shown that, in this age group, the use of endoscopy can be of vital importance in expanding or qualifying radiological data. Special attention was paid to gastric lesions caused by anti-inflammatory treatment. The overall incidence in this series was 37%, and this correlated very closely with the incidence of 31% previously documented by the same authors in a middle-aged population of rheumatic patients. It is concluded that endoscopy is of indisputable value in facilitating the diagnosis and treatment of gastro-intestinal disorders in the elderly.

Aged↗
PubMed1980

The use of rociverine as premedication for endoscopy of the upper gastro-intestinal tract: a double-blind controlled clinical trial.

The effect of rociverine (10 or 20 mg given intravenously) as premedication in upper gastro-intestinal tract endoscopy was examined and compared to that of hyoscine butylbromide (20 or 40 mg given i.v.) in a double-blind study involving 121 patients. The drugs' effects were assessed on the degree of opening of the pyloric sphincter and the endoscopist's rating of drug performance. The study showed that rociverine did not differ statistically from the reference drug on either count. No adverse effects were noted.

Adult↗
PubMed1979

Pirenzepine versus cimetidine in the treatment of duodenal ulcer.

Fifty-five patients with active duodenal ulcer have completed, up to today, a one-month double-blind trial to compare the effects of pirenzepine (150 mg daily), cimetidine (1 g daily) and placebo on the healing of duodenal ulcer. Fifteen (71%) of the 21 patients treated with pirenzepine had healed ulcers compared with 14 (82%) receiving cimetidine (P less than 0.05. In the placebo group there were 7 (41%) healed ulcers. Symptomatic improvement in patients given pirenzepine was as substantial as in cimetidine-treated patients. No adverse effects were noted.

Adult↗