PubMed Health⌕ Search

Biomedical subjects

M Lechleitner

Publications and source records attributed to M Lechleitner.

44 records · Page 3Linked to original sources
PubMed1985

[Host reaction in non-Hodgkin's lymphomas: tumor infiltration with monocytes/macrophages].

The number and distribution of macrophages in deep frozen sections of various non-Hodgkin lymphomas (NHL) were evaluated in situ by immunomorphometry using stereological methods. The density of infiltration was correlated with clinical parameters. Several monoclonal antibodies reactive with antigens present on cells of the monocyte-macrophage series were tested in parallel. The density of macrophages within NHL of high malignancy with 11.3 X 10(3) +/- 1739 positive cells/microliter tumour tissue was higher than in those of low malignancy (4.7 X 10(3) +/- 628). The highest value of positive cells was found in immunoblastic lymphoma (17.3 X 10(3) +/- 2773), differing significantly from other histological subtypes of NHL and normal tissue (normal tissue: 6.5 X 10(3) +/- 1027, p less than 0.005). With regard to clinical parameters, localized NHL displayed lower infiltration numbers than generalized NHL. Possible mechanisms of influencing tumour growth are discussed in view of the large infiltration density of the monocyte macrophage series in NHL of unfavourable histology and advanced clinical stage.

Antibodies, Monoclonal↗
PubMed1985

Effect of human recombinant alpha-2- and gamma-interferon on the growth of human cell lines from solid tumors and hematologic malignancies.

We studied the growth effects of human recombinant interferon (IFN)-alpha-2 and -gamma on various human cell lines. Four cell lines from solid tumors (WiDr, CCL 185, BT 20, KB) and three cell lines from hematologic malignancies (U 937, U 266, MOLT 4) were chosen. The study was performed using two different assays: (1) a soft agar cloning assay, and (2) a monolayer and suspension culture. In the soft agar assay alpha-IFN inhibited colony growth of 6/6 lines tested (the line MOLT 4 could not be plated); in the monolayer assay it inhibited proliferation of 6/7 lines tested. Gamma-IFN showed inhibitory effects on 5/6 cell lines tested in the soft agar assay, but on one line (CCL 185) low concentrations of gamma-IFN led to a significant increase in the number of colonies. Using the monolayer assay, gamma-IFN showed inhibition of 6/7 lines tested, whereas a stimulation of growth could not be observed. With a combination of alpha- and gamma-IFN, synergistic effects were seen on a histiocytic cell line (U 937) in both assays and a marginal synergism on the T-cell line MOLT 4 in the monolayer assay.

Cell Division↗
PubMed1983

[Type, number and mode of distribution of cases of poisoning at the University Department of Internal Medicine, Innsbruck].

In the course of one year 357 patients were treated in our department for poisoning, nearly always with suicidal intent. Altogether 249 patients were admitted to the wards for 24 hours or longer, and 108 of these (44.6%) were taken into the intensive care unit. Apart from myocardial infarction (276 patients/year), poisoning is the most common reason for admission to the intensive care unit. The age distribution showed a maximum between 15 and 20 years. Only one case proved fatal, representing a mortality rate of 0.3%.

Adult↗
PubMed1983

[Recurrence in Hodgkin's disease: incidence, therapy and prognosis. (Experience with 134 patients)].

Of 157 patients with Hodgkin's disease treated between 1970 and 1981 an assessment of the clinical course was possible in 134 cases. Remissions were achieved in 120 patients (89%). 51 patients (43%) relapsed subsequently. The highest relapse rates were seen in advanced stages of the disease and in patients with unfavourable histological subgroups (mixed cellularity and lymphocyte depletion). Second remissions were achieved in 40 patients (78%), the remission being complete in 33 cases (65%). Patients who had received radiation therapy primarily, responded significantly better to secondary treatment than patients who had received chemotherapy initially. The predicted five-year survival rate is 70% for patients with complete remission after relapse and 34% for patients with partial remission. Though a relapse of Hodgkin's disease can frequently be treated with curative outcome, patients with certain high-risk factors (e.g. large mediastinal tumour, stage III2, lymphocyte depletion histology) need more intensive induction therapy.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1983

[Therapy of malignant lymphomas].

Prognostic factors in patients with Hodgkin's disease and the non-Hodgkin lymphomas are reviewed and discussed since they form the basis of the therapeutic approach to these conditions. Hodgkin's disease is treated according to stage, histology and other prognostic criteria and the appropriate management is presented in tabular form. In the non-Hodgkin lymphomas, prospective studies using the Kiel classification indicated that these lymphomas could be subdivided into types of low-, intermediate- and high-grade malignancy, each requiring different treatment modalities. An expectative approach is often, but not always, recommended in lymphomas of low malignancy. The natural history of lymphomas of high-grade malignancy is unfavourable and, usually, prolonged survival is observed only in those cases in which a complete remission is achieved. Our therapeutic approach to the various forms of these lymphomas is based on the stage of the disease and the respective schedules are summarized for lymphomas of low- and high-grade malignancy. Finally, the chances of cure in Hodgkin's disease and in the non-Hodgkin lymphomas are discussed and recent developments are mentioned.

Adolescent↗