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Biomedical subjects

M Lecona

Publications and source records attributed to M Lecona.

14 recordsLinked to original sources
PubMed2004

Cutaneous necrosis induced by acenocoumarol.

Cutaneous necrosis is an infrequent but well-documented complication of oral anticoagulants. In the pathogenesis of cutaneous necrosis induced by oral anticoagulants recent hypotheses favour the combined role of local factors and a transient unbalance of coagulation mechanisms leading to an hypercoagulable state. There exists a genetic factor that determines a decreased level of two vitamin-K dependent glycoproteins, namely protein C and protein S. We present the case of an obese woman that developed an extensive cutaneous necrosis while receiving acenocoumarol for a deep venous thrombosis. She had an heterozygous deficit for protein C. The histopathologic findings of vessel thrombi and red blood cell extravasation were consistent with the clinical picture. A biopsy specimen taken from an initial lesion disclosed images of leucocytoclastic vasculitis. We reviewed the literature focusing on the pathogenesis and the histopathology of the disease.

Acenocoumarol↗
PubMed1996

Erythema elevatum diutinum in human immunodeficiency virus-infected patients--report of a case and review of the literature.

Erythema elevatum diutinum (EED) is a rare chronic disease of unknown origin, part of the spectrum of cutaneous leucocytoclastic vasculitis. A case of EED in a 32-year-old HIV-infected male patient, with no previous opportunistic infections and a CD4+ cell count of less than 200/mm3, is reported. Therapy with oral dapsone (100 mg/day for 15 days) resulted in clinical cure with no relapse after 6 months of follow-up. To our knowledge, only six cases of EED in HIV-positive patients have been reported to date. A brief review of these seven cases is described.

Adult↗
PubMed1996

Rosacea-like demodicosis in an HIV-positive child.

A second case of rosacea-like demodicosis in an HIV-positive child was seen at our center. No such cases have previously been published. The present case is a 2-year-old boy, the son of an HIV-positive mother, who responded well to oral erythromycin and topical metronidazole. The frequency of rosacea-like eruptions in HIV-negative children is very low. However, the incidence of these eruptions in HIV-positive children may have been underestimated. The pathogenic role of Demodex mites is discussed as well as the possible mechanisms for an exaggerated reaction.

AIDS-Related Opportunistic Infections↗
PubMed1996

Leishmania infection occurring in herpes zoster lesions in an HIV-positive patient.

We report the first case of co-infection with herpes zoster and leishmania in the same lesion, on the face of a 29-year-old female, who was an intravenous drug user and who was HIV positive. The infection was initially resistant to acyclovir and itraconazole, and the patient died due to severe internal complications, not attributed to visceral leishmaniasis. The prevalence of leishmania infection in the Mediterranean countries is increasing among the HIV-positive population because of the existence of human carriers. Paradoxically, most of these patients show mild forms of visceral leishmaniasis.

AIDS-Related Opportunistic Infections↗
PubMed1979

[Multiple clear cell acanthoma in a patient with psoriasis. Treatment with 5-fluorouracil].

Clear cell acanthoma (CCA) is a benign skin tumour, seldom multiple, perfectly individualized both clinically and histologically. The tumour is more usually mistaken for a seborrheic keratosis. There are large amounts of glycogen within the epidermal cells as can see upon staining with the PAS reaction. Melanogenesis is decreased. The enzymes characteristic of eccrine sweat glands are also decreased. The authors report a 67 years old psoriatic female with 15 C.C.A. They emphasize the treatment with topic 5FU particularly interesting in the multiple forms.

Administration, Topical↗