Biomedical subjects

M Legris

Publications and source records attributed to M Legris.

5 recordsLinked to original sources

PubMed1998

Noise exposure profile among heavy equipment operators, associated laborers, and crane operators.

This study, conducted in 1987 and 1988, has made it possible to quantify exposure to noise among heavy equipment operators, associated laborers, and crane operators. The average daily noise exposure was 84 to 99 dBA for heavy equipment, 90 dBA for the laborer, and 74 to 97 dBA for the crane operator. The main sources of noise to which heavy equipment operators are exposed are vehicle engines and the muffler exhaust system, usually located near the operator. The presence of insulated cabs such as those found on power shovels, backhoes, wheel loaders, and graders help reduce noise exposure. The type of tasks carried out by the laborers, the sources of noise from heavy equipment around which they work, and the manual equipment they use determine the noise levels to which such workers are exposed. In the case of crane operators, an insulated cab significantly reduces the operator's exposure to engine noise.

Environmental Monitoring↗

PubMed1994

Cerebral dysgenesis and lactic acidemia: an MRI/MRS phenotype associated with pyruvate dehydrogenase deficiency.

Pyruvate dehydrogenase complex (PDHC) is an intramitochondrial multienzyme complex essential for the aerobic oxidation of glucose. The majority of patients with PDHC deficiency have abnormalities in the major catalytic and regulatory subunit, E1 alpha, which is encoded on the X chromosome. The clinical spectrum of PDHC deficiency is heterogeneous, particularly in heterozygous females, and diagnosis may be difficult. Three affected infant girls with PDHC deficiency were investigated. All had dysmorphic features, microcephaly with profound global developmental delay, and hypotonia. Systemic acidosis was absent, although serum lactate and pyruvate were abnormally elevated. Magnetic resonance imaging revealed hypoplasia of the corpus callosum in all patients. Proton magnetic resonance spectroscopy of brain revealed large increases in relative signal intensities for lactic acid and decreases in the relative signal intensities of N-acetylaspartate, a marker of neuronal damage or less. Phosphorus MRS of muscle revealed abnormally low phosphorylation potentials for all these patients, although the degree of abnormality was variable and not directly correlated with the amount of brain lactate. It is proposed that cerebral dysgenesis and cerebral lactic acidemia as shown by magnetic resonance imaging and proton magnetic resonance spectroscopy are useful diagnostic clues to PDHC deficiency, particularly in females in whom variable patterns of X-inactivation reduce sensitivity of laboratory diagnosis based on the biochemical studies of peripheral tissues. In addition, muscle bioenergetic abnormalities in conjunction with CNS dysfunction may contribute to profound hypotonia in this disorder.

Acidosis, Lactic↗

PubMed1989

[Results of detection and early treatment of Chlamydia trachomatis infections in pregnancy].

The authors report and comment on the results of a prospective study of the usefulness of early treatment of Chlamydia trachomatis infections in pregnant women. The diagnosis is based on a serological examination carried out in the first trimester of pregnancy. 60 women were treated by antibiotics and they were compared with 51 women who were not treated. The two groups were statistically comparable. There was a significant drop in perinatal complications due to Chlamydia trachomatis. The difference was particularly significant as far as low birth weight and the incidence of conjunctivitis in the newborn was concerned. These results show how useful it is to carry out serological screening and early treatment of Chlamydia trachomatis infections in pregnancy.

Adult↗

PubMed1988

[Pharyngeal epignathus teratoma. Echographic and prognostic study].

Pharyngeal epignathus teratoma is an isolated benign tumour, but the prognosis is very indeed because it can so easily obstruct the respiratory or the digestive pathways. Only rarely has this teratoma been diagnosed by ultrasound in the literature. The authors, having had a personal case, decided to discuss the problems in making the diagnosis by ultrasound and in deciding what treatment to carry out.

Abortion, Therapeutic↗

PubMed1987

[Uterine retroversion. A simple surgical cure].

In 20% of the cases, painful symptoms which cannot be dismissed in general practice are experienced by women with uterine retrodeviation. The technique described here is based on anatomical reduction of Douglas' pouch with restoration of tension in the uterosacral ligaments. It is simple and rapid as expected for a minor anatomical defect. The creation of two perpendicular peritoneo-ligamentous planes ensures its solidity. The effectiveness and safety of this technique has been confirmed by a series of more than 70 patients 50% of whom were examined at regular intervals for more than 5 years after surgery.

Female↗