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Biomedical subjects

M Legros

Publications and source records attributed to M Legros.

At least 19 recordsLinked to original sources
PubMed1992

Bone marrow transplantation prolongs survival after relapse in aggressive-lymphoma patients treated with the LNH-84 regimen.

PURPOSE: Of the 737 patients with aggressive lymphoma who were treated with the LNH-84 regimen, 244 with progressive disease after complete remission or partial response were analyzed retrospectively to determine the influence of intensive chemotherapy with bone marrow transplantation (BMT) on survival. PATIENTS AND METHODS: Forty-four patients were treated with salvage chemotherapy, followed by autologous bone marrow transplantation (ABMT) in 40 and allogeneic BMT in four. The other 200 patients were treated with chemotherapy only. RESULTS: Salvage treatment produced an objective response in 57% of the patients; 23% achieved a second complete remission. Median overall survival was longer for patients who were treated with ABMT than for those who were treated with chemotherapy only (12.4 v 6.7 months), as was median freedom from progression (FFP) survival (7.7 v 4 months). In multiparametric analysis, ABMT and normal initial lactic dehydrogenase (LDH) level were the primary parameters associated with longer survival. This is also true when (1) only patients younger than 60 years of age, (2) only patients who responded to salvage regimen, or (3) only patients with both conditions were included in the analysis. Patients who were not transplanted had a 1.69 to 2.26 relative risk of dying from their disease compared with those who were treated with intensive chemotherapy plus ABMT. CONCLUSION: This study produced more evidence of the favorable impact of intensive chemotherapy with bone marrow rescue on survival in lymphoma patients who had relapsed.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1978

[Hyperfractionated radiotherapy in 56 patients with tumors of the head and neck (author's transl)].

A new method of irradiation known as hyperfractionated radiotherapy was studied in 56 patients with cancers in the region of the ear, nose, and throat. The dose was 72 grays given during 80 sessions over a period of 28 days, with a rest period of two weeks at the half-way point. Each session lasted 2 hours. The results (complications and survival rate) were compared with those obtained in a control group treated with 70 grays in 35 sessions over a period of 7 weeks. The complication rate was 21% in the series treated with hyperfractionated radiotherapy, against 19% in those given classical treatment (results not significant). The survival rate was better, however, (63% against 33% after 18 months), for the patients treated with this new method of irradiation.

Clinical Trials as Topic↗
PubMed1978

[Hyperfractionated irradiation with cobalt 60 in ORL cancers].

So-called "hyperfractionated" radiotherapy is aimed at obtaining synchronisation of tumour cells and to kill the cells synchronised in this way. The technique has been used now for approximately a year and a half in the treatment of 45 advanced or inoperable squamous carcinomas of the upper respiratory and digestive tract. The initial results are encouraging. Oncological sterilisation of the lesions is obtained at the price of actinic reactions which rapidly disappear, but also tumour necrosis, which indicates the need for review of the protocol.

Cobalt Radioisotopes↗
PubMed1976

[Problems presented by closed laryngeal-tracheal injuries].

The authors consider the problems raised by severe closed laryngotracheal trauma and report 4 cases. -the immediate tisk to life is due to direct involvement of the respiratory tract requiring emergency measures including cardiorespiratory resuscitation in cases of acute asphyxia. -the origin of the initial respiratory distress, if not obvious from the start, may be suspected in view of the difficulties or impossibility of tracheal intubation, which is also liable to aggravate lesions due to trauma. It is one of these rare cases of resuscitation where emergency tracheotomy is essential. It permits also early, precise surgical exploration. -in cases of fracture of the larynx, a wound of the trachea or rupture and separation of the trachea, the reconstruction must be constructiononstruction must be considered within the first 48 hours. Provision of food and resting of the larynx may be conciliated by installing an esophageal catheter or performing a gastrostomy. Benign trauma, such as contusion or laryngeal commotion, requires close supervision association with medical treatment designed to prevent the onset of lesional oedema.

Adolescent↗
PubMedDate not supplied

[Wegener's granulomatosis with atypical beginning (author's transl)].

The authors report a case of Wegener's disease starting in the sub-maxillary region and spreading to the auricular region. The diagnosis was evoked by the correlation between the granulomatous lesions observed in the sub-maxillary region and on the tympanic membrane; there was also renal failure of rapid onset. A remission of five months has been obtained by treatment with corticosteroids and immunodepressant agents. Around this case the authors collected 267 cases from the literature and point out the rarity of the auricular form and the exceptional nature of the sub-maxillary localization of this disease.

Adrenal Cortex Hormones↗