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Biomedical subjects

M Leigh

Publications and source records attributed to M Leigh.

12 recordsLinked to original sources
PubMed1999

The effects of slow- and fast-rhythm classical music on progressive cycling to voluntary physical exhaustion.

BACKGROUND: To investigate, based on the parallel information processing model and arousal hypothesis, whether musical tempo and its manipulation during exercise affect the maximal workload (watts) achieved during progressive cycling. METHODS DESIGN: repeated measures experiment that involved one control and four treatment conditions. SETTINGS: the experiment was performed in a controlled laboratory environment. PARTICIPANTS: twenty-four male and female volunteers, recruited from among a University population, were tested. INTERVENTION: the data collection proceeded in five counterbalanced test-sessions that included control (C), slow music (SM), fast music (FM) slow to fast music (SFM) and fast to slow music (FSM) interventions. In the last two conditions, musical tempo was changed when the participant's maximal HR reserve has reached 70%. In all test-sessions, participants started to cycle at 50 watts and then the workload was increased in increments of 25 watts every minute until self-declared exhaustion. Maximal ergometer cycling was defined as the workload at the last completed minute of exercise. MEASURES: workload, HR, and postexperimental ratings of test-session preferences were the dependent measures. RESULTS: Significantly higher workload was accomplished in the SFM condition. No between-session differences were seen in HR. The results also yielded significantly better "efficiency", in terms of workload/HR reserve ratio, in the SFM session. PARTICIPANTS preferred the FM and SFM sessions more than the other sessions. CONCLUSIONS: Switching to FM during progressive exercise results in the accomplishment of more work without proportional changes in HR. These effects may be due to distraction from fatigue and are, apparently, dependent on the attention capturing strength of the distracting stimulus.

Adult↗
PubMed1983

Mismatched family donors for bone-marrow transplantation as treatment for acute leukaemia.

35 patients were treated for acute myeloid leukaemia or acute lymphoblastic leukaemia with allogeneic bone-marrow grafts from a parent, child, or sibling who was mismatched at the major histocompatibility complex (MHC). 11 of these patients are alive at least 6 months after grafting, 5 of them after more than 2 years. Of the 15 patients aged under 20 at the time of the graft, 8 are alive and well 6 months to 3 years later. Cyclosporin A was given to all patients after grafting. 1 patient died of acute graft-versus-host disease and in 2 other cases this was a major factor in their death. Graft failure caused the death of 2 patients. 4 patients died of recurrent leukaemia. A fatal complication in 12 patients was pulmonary oedema, often associated with convulsions, intravascular haemolysis, and renal failure. Some of these patients had viral or bacterial infections, but in the majority the syndrome was not associated with demonstrable infection. This syndrome, in which the essential lesion appears to be vascular, was much more common in recipients of mismatched than matched grafts. 3 others died from lung disease in which infection was a factor.

Acute Disease↗
PubMed1983

Cyclosporin A following matched and mismatched family allogeneic bone marrow transplants.

One hundred and nineteen patients with leukaemia have received CSA as prophylaxis against acute GVHD following sibling MHC matched (84) or family member mismatched bone marrow transplants (35). four recipients of matched transplants (3%) died of acute GVHD, a marked improvement on our previous results using methotrexate (26 patients; 27% died of GVHD). Thirty-five patients received mismatched transplants, 15 were under the age of 20 years and eight are alive and in remission, the longest survivor being one at 2 1/2 years after transplant.

Bone Marrow Transplantation↗
PubMed1982

Comparison of the cerebral function monitor and plasma concentrations of thiopentone and alphaxalone during total i.v. anaesthesia with repeated bolus doses of thiopentone and althesin.

Repeated bolus doses of thiopentone or Althesin were administered to 10 patients every 240 s while cerebral electrical activity was recorded with the Cerebral Function Monitor (CFM). Peripheral venous blood samples were collected at 60 and 225 s after each bolus dose for the measurement of plasma concentrations of the drugs. Significant correlations in the range r = 0.56-0.96 (P = 0.02-0.00001) between plasma thiopentone or alphaxalone concentrations and the upper and lower edges of the CFM trace were found. For the patients with relatively poor correlations, better correlations were obtained when 60- and 225-s sample were analysed separately.

Alfaxalone Alfadolone Mixture↗