Fetal hydrocephalus and ear anomalies associated with maternal use of isotretinoin.
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Abnormalities, Drug-Induced↗
Biomedical subjects
M Leitner
Publications and source records attributed to M Leitner.
Identification by affinity labeling of potential sites in 23-S rRNA interacting with the 3' end of tRNA.
A derivative of tRNAPhe carrying at its 3' end a photolyzable group was chemically synthesized by coupling p-azidobenzoylglycylhydrazide to periodate-oxidized tRNA. The reaction converts the 3'-terminal ribofuranoside residue into a six-membered ring. The binding of p-azidobenzoylglycylhydrazide-tRNA to 70-S ribosomes resembles the binding of Phe-tRNA in its requirement for poly(U) and Mg2+ dependence. Irradiation at wavelengths greater than 300 nm of complexes of p-azidobenzoylglycylhydrazide-tRNA and 70-S ribosomes results in the covalent binding of approximately 20% of the reversibly bound tRNA to the ribosomes. The labeling occurs predominantly at a single site in 23-S rRNA within the sequence included in the 18-S fragment. To identify the modified sequence, an RNase A digest of 23-S rRNA was fractionated on a hydrophobic matrix (Porapak Q) and adsorbed and non-adsorbed fractions were compared by fingerprint analysis. A relatively intense spot was observed in the expected region in the fingerprint of the adsorbed fraction. The presence of an unusual nucleotide in the sequence of this oligonucleotide was demonstrated by a mobility-shift analysis of a partial nuclease P1 digest. The sequence derived is G*-A-A-G-C (the asterisk denoting the site of modification). Sequences at six positions in the 23-S rRNA are compatible with the sequence of the oligonucleotide determined. Of the six positions five are located within nucleotides 1467-1887. This region of approximately 400 nucleotides is likely to include the sequence interacting with the 3' end of tRNA and possibly forming part of the peptidyl-transferase center.
Affinity Labels↗
The cardiovascular effects of dopamine in the severely asphyxiated neonate.
The cardiovascular effects of dopamine were evaluated in 14 severely asphyxiated neonates. After a period of stabilization, either dopamine 2.5 micrograms/kg/minute or placebo was infused in a randomized double-blind protocol. In seven dopamine-treated infants, echocardiographically determined shortening fraction and mean velocity of circumferential fiber shortening increased when compared to preinfusion values (P less than 0.05). There was no significant change in these echo indices of cardiac function in the placebo-treated group. Systolic blood pressure rose in the dopamine group when compared to predopamine infusion values and to the postinfusion values of the placebo group (P less than 0.001 and 0.025, respectively). Diastolic blood pressure increased to a small degree in the dopamine group. There was no significant change in heart rate or echocardiographically measured systolic time intervals. Low doses of dopamine increase cardiac performance and raise systolic blood pressure in the severely asphyxiated neonate.
Asphyxia Neonatorum↗
[Milk of calcium in a renal cyst].
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Cholelithiasis↗
[Molybdocene dichloride as an antitumor agent (author's transl)].
The antitumor activity of molybdocene dichloride is tested against Ehrlich ascites tumor in CF1 mice. The application of 75 of 100 mg/kg 24 h after transplantation achieves 100% tumor inhibition until day 30. Following the d0 and d1 metallocene dichlorides of titanium and vanadium, molybdocene dichloride is the first analogous d2 system revealing similar antineoplastic properties.
Animals↗
Hyperbilirubinemia in association with late onset group B beta-hemolytic streptococcal infection.
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Female↗
[Double-contrast examination in hypotonia in the operated stomach (author's transl)].
The technique of examination, as well as the extent and quality of visualisation are described, basing on a selected case material of patients who had been subjected to stomach surgery; the extensive possibilities of diagnosis are studied. Hypotonia and double contrast offer considerable advantages over the conventional examination of the operated stomach. Assessment of mucosal conditions, especially in the anastomosis range, is facilitated, thus offering a chance to improve the method of diagnosis. Hypotonic double-contrast examination should always be performed if there are no possibilities of endoscopic examination.
Aged↗
A non-linear mathematical model for computerized analysis of mood curves: construction of the model and its application to the mood curves of depressive and schizophrenic inpatients.
A non-linear mathematical model for the computerized description of mood curves is presented. This model reaches a high goodness of fit to the real data and seems superior to a linear model recently proposed. Using this model in a computer program for describing the mood data of a large sample of psychiatric inpatients, significant and clinically meaningful group differences between the mood curves of schizophrenic, endogenous depressive, and neurotic depressive inpatients could be demonstrated. The application of this methodology might be helpful among others in the field of evaluative research.
Antidepressive Agents↗