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M Lemonnier

Publications and source records attributed to M Lemonnier.

43 records · Page 3Linked to original sources
PubMed1976

Characterization and structure of a sialic acid-containing hexasaccharide isolated from human pregnancy urine.

A hexasaccharide containing sialic acid has been isolated from the urine of pregnant women. It contains D-glucose, N-acetyl-D-glucosamine, and sialic acid in the proportions of 2:1:1:2. Its structure, established by methylation analysis, enzymic digestion, and potassium borohydride reduction, is that of lacto-N-tetraose with one of the residues of sialic acid linked alpha-(2 leads to 3) to the terminal nonreducing residue of D-galactose, and the other sialic acid residue linked alpha-(2 leads to 6) to the N-acetyl-D-glucosamine residue. This hexasaccharide is related to human pregnancy, as it has not been found in nonpregnant, normal-woman urine and is present in human milk.

Female↗
PubMed1976

Low-molecular-weight carbohydrate-rich compounds in pregnancy urine.

The isolation and the chemical composition of two low-molecular-weight carbohydrate-rich fractions individualized in non-pregnant and pregnant women urine is reported. The first one is almost composed of glycopeptides whereas the second one gathers the major part of oligosaccharides. It is shown that at the 8th month of pregnancy, both fractions contain a larger amount of neutral hexoses, N-acetylneuraminic acid, N-acetylhexosamines 6-deoxyhexoses and aminoacids than in normal urine. Further, a discrimination is observed in the enhancement of each fraction. The increased amount of fraction 2 is observed as soon as the 17th week of pregnancy, whilst the amount of fraction 1 increases slowly from the 17th week until the end of pregnancy. Both fractions exhibit a tremendous increase of all carbohydrates, one week after delivery. The increased amount of glycopeptide material could be related to glycoproteins catabolism, and the increased amount of oligosaccharide material could be related to the mammary tissue metabolism.

Amino Acids↗
PubMed1975

Plasma galactocerebrosides in multiple sclerosis.

Plasma cerebrosides were examined in 12 cases of multiple sclerosis which were compared to normal controls and patients with cerebrovascular accidents. A screening was performed so as to select patients with levels above to normal by means of thin-layer chromatography of the lipid extract. Glucose seems to be the only hexose to be found normally in plasma cerebrosides. The presence of galactocerebrosides may be a biological test for demyelination, as their presence seems to be related to the evolutionary state of multiple sclerosis. In a severe cerebrovascular accident, galactocerebrosides were also found.

Adult↗