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Biomedical subjects

M Leonardi

Publications and source records attributed to M Leonardi.

At least 19 recordsLinked to original sources
PubMed1992

Chronic spastic atrophic hemiparesis with benign course.

We present the clinical and neuroimaging data of 4 patients (mean age: 62 years, range 54-67; mean follow-up: 19.5 years, range: 26 months-29 years) with chronic spastic atrophic hemiparesis (CSAH). Neuroimaging findings were non specific, CT scan and MRI showing white matter lesions located within the centrum semiovale in two cases, parieto-occipital lobe and pons in one case each. This study underlines that patients with CSAH may have a good long-term prognosis. MRI studies may demonstrate associated lesions within the white matter or brainstem and are advisable in all subjects with CSAH, but further studies are necessary to clarify the nature of the observed lesions.

Aged↗
PubMed1992

Neurological impairment in congenital bilateral ptosis with ophthalmoplegia.

A case is described of congenital bilateral ptosis and ophthalmoplegia due to incomplete bilateral paralysis of the third cranial nerve associated with dysmorphisms, brain malformations and epileptiform EEG abnormalities. We hypothesize that in our case the ophthalmological disturbance is due to mesencephalic impairment. In literature there are few reports of congenital bilateral paralysis of the third cranial nerve and they lack detailed MRI findings. We stress in patients with congenital third cranial nerve palsy the importance of thorough neurological investigations including prolonged wake-sleep EEG monitoring as well as CT scan and MRI to establish the origin of the disorder.

Blepharoptosis↗
PubMed1992

[Research on the understanding of the relation between patient, gynecologist and breast disease].

The aim of our work was to identify the most important aspects of the relationship between gynecologist and patient who presents himself during our observation because of breast pathology. In order to evaluate all that said above we asked patients to compile a questionnaire characterized by different questions. The results obtained were very satisfactory and at the same time they lead us to a greater engagement towards the prevention of breast neoplasia, especially for those women predisposed to such disease.

Breast Diseases↗
PubMed1991

Serum creatine kinase activity and its changes after a muscle biopsy.

The significance of the absolute elevations of serum creatine kinase (CK) levels after intense exercise and injuries was studied by measuring CK activities from seven healthy active males during a 2-week period, with a muscle biopsy taken between the first and second week. Most of the subjects (three lifters and two runners) carried on their normal exercise activities, while two lifters stopped training during the 2 weeks. The weight of the biopsy, number of fibres, percentage of fibre types, and cross-sectional areas of the muscle fibres were measured. The CK levels of the non-active subjects and runners remained consistently low during the control week, whereas those of the lifters were usually 500% greater than those of the other two groups, and fluctuated with the intensity of their workouts. A muscle biopsy, having a mean weight of 71.3 mg and containing 1800 fibres, increased the CK values by approximately 100 units litre-1 (U l-1) in most of the subjects. One runner injured his right hamstring muscles 2 days prior to the biopsy, and his CK values rose from 50 to 4400 U l-1. The increases in CK after the biopsy were not related to fibre type, activity, weight of the biopsy, or number or size of fibres removed. These results indicate that: (1) CK values are consistently lower in normal subjects and runners than in lifters. (2) Weight training results in chronic elevations of CK. (3) Compared to a muscle biopsy, muscular injury dramatically increases CK levels. (4) Elevation of serum CK is observed as early as 1 h after an intense weight-lifting session.(ABSTRACT TRUNCATED AT 250 WORDS)

Biopsy, Needle↗
PubMed1989

High-dose contrast-enhanced computed tomography (CECT) with iopamidol in the detection of cerebral metastases. Tolerance of the contrast agent.

Intravenously administered iodinated contrast media have been demonstrated, since early experience with computed tomography of the brain, to improve clinical value of the procedure for detecting intracranial lesions. There is no universal agreement about the amount and the method of administration of the contrast medium. Many authors maintain that the use of large doses gives better results for the diagnosis of tumors and metastases. The purpose of this paper is to evaluate the tolerance of iopamidol administered by rapid intravenous infusion in a large number of patients undergoing contrast enhanced computed tomography to detect brain metastases. The authors examined 969 consecutive adult patients suffering from lung cancer, brain metastases have been detected in 17% of cases. Adverse reactions to contrast media occurred in 3 patients. Non ionic contrast media are recommended in this diagnostic procedure.

Adult↗
PubMed1989

Computed tomography.

Lacunes consist of small vascular lesions with a volume of between 2 and about 30 mm. These lacunar infarctions are determined by an ischemia caused by obstructive diseases of small terminal vessels in the deep areas of the brain. While magnetic resonance currently appears to be a more sensitive diagnostic tool than computed tomography (CT) as far as research into small cerebral lesions is concerned, CT still remains a very valid and more convenient instrument for the screening of these quite frequent pathologies.

Cerebral Infarction↗
PubMed1988

Dynamic ultrasonography of capsulo-ligamentous knee joint traumas.

Ultrasonography was performed on 10 patients with acute posttraumatic conditions of the knee in which X-ray films could exclude the presence of fractures. In 2 of 10 cases, the sonographic picture was normal; in the remaining 8 patients, ultrasonography disclosed capsulo-ligamentous lesions of different degrees of severity that were confirmed by surgery in 5 of 8 cases. The main sonographic signs of articular traumas were abnormal widening of the joint space (7 cases), intra-articular hemorrhage (8 cases), rupture of the medial collateral ligament (4 cases), or irregularity of its structure (3 cases). Ultrasonography is proposed as an effective and simple first-line method for the study of knee joint traumas. It can be performed in all cases presenting with painful joint swelling without radiographical evidence of fractures.

Humans↗
PubMed1986

Iopamidol 150. A low iodine content non-ionic water-soluble contrast medium for CT myelocisternography.

Results of a clinical trial in CT myelocisternography performed with a new reduced concentration of iopamidol (150 mg I/ml) are reported. This compound is characterized by very low osmolality and osmotic pressure close to those of blood and CSF. Thirty patients were examined. Before, during and after the procedure pulse rate and blood pressure were recorded, EEG was taken and neurologic examination performed. After the examination no alteration in these parameters was recorded. The demonstration of the subarachnoid space and related structures was invariably adequate for diagnosis. In no case was a repeat study using a higher concentration of contrast medium needed. Mild reactions occurred only in three patients (10%). The authors conclude that iopamidol 150, owing to its safety and good imaging capacity, is useful in CT imaging of the subarachnoid space.

Adolescent↗
PubMed1986

Computed tomography of the lumbar spine. Experience with an Expert System in computer aided diagnosis.

The authors report their experience in the formulation of an Expert System for computer aided diagnosis in the examination of the lumbar spine with computed tomography. A large number of steps are identified in the process of diagnostic evaluation of CT examinations; about 80 decisional rules are considered and arranged in five 'areas'. The Expert System under study is a first proposal, intended for use by radiologists with some basic training.

Diagnosis, Computer-Assisted↗
PubMed1986

Ultrasonography in the diagnosis of soft tissue tumours.

The diagnosis of soft tissue tumours by the traditional instrumental methods often creates problems. Indeed, it is fairly difficult to make an accurate pre-operative diagnosis of a neoplasm of the soft tissues. The authors therefore employed ultrasonography to investigate 29 soft tissue tumours. They consider that ultrasonic assessment can make a valuable contribution to diagnosis in this type of pathology and provide information about the benign or malignant character of the neoplasm.

Adult↗