M Leonhardt — Page 2 | PubMed Health

PubMed1985

[Duration of the effect of acetylsalicylic acid on circulating platelet aggregates in cerebral infarct patients].

The number of "circulating platelet aggregates" was examined in 33 patients who had suffered a cerebral infarct. Examination was done before onset of treatment with acetylsalicylic acid (ASA), 2 hours after ASA medication, and 12 hours after ASA medication, employing a modification of the platelet function measuring method according to the authors Wu and Hoak. The significant increase in the number of circulating platelet aggregates, compared with healthy persons, was found to be significantly reduced 2 and 12 hours after ASA medication. After 2 hours, we found in only 6% of the patients an increase in the number of circulating platelet aggregates above the mean value + triple (simple) standard deviation for n = 71 healthy controls. 12 hours after ASA administration 30% of the patients had again passed beyond the liberally defined standard level of the method.

Adult↗

PubMedDate not supplied

Effect of hydroxycitrate on food intake and body weight regain after a period of restrictive feeding in male rats.

We examined whether dietary supplementation of hydroxycitrate (HCA), a competitive inhibitor of the extramitochondrial enzyme ATP-citrate-lyase, which inhibits lipogenesis, reduces food intake and body weight regain in rats after 10-15% weight loss. In four experiments, 24 male rats were fed restrictively (10 g/day) for 10 days and then given ad lib access to one of four different diets (HI-Suc=high sucrose; HI-Glu=high glucose; Chow=grounded standard rat chow; HI-Glu+Fat=high glucose+fat) varying in the content of fat and low molecular carbohydrates for the following 10 days. For half of the rats (n=12), the ad lib diet was supplemented with 3% (w/w) HCA. HCA reduced body weight regain with all diets except Chow. HCA also reduced food intake temporarily with three of the four tested diets. The suppressive effect of HCA on food intake was particularly strong with the HI-Glu+Fat diet (fat=24% of energy). With Diet HI-Glu and HI-Glu+Fat HCA reduced the feed conversion efficiency (cumulative body weight regain (g)/cumulative food intake (MJ)) during the 10 ad lib days, suggesting that it also increased energy expenditure. This effect seemed to be positively related to the glucose content of the diet. All in all, HCA reduced body weight regain after substantial body weight loss, and the effects are presumably linked to its inhibiting effect on lipogenesis, but the exact mechanism still has to be determined.

Animals↗