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Biomedical subjects

M Lepore

Publications and source records attributed to M Lepore.

52 records · Page 3Linked to original sources
PubMed1990

[100 cases of bronchial mechanical sutures].

The Authors report their experience with stapler model T.A. 30 in lung resections; 100 stapled sutures were carried out in the IV Surgical Department of the University "La Sapienza" of Rome, during the period 1980-88. The use of stapler with two rows of staples allows a secure closure of the bronchial stump. Moreover, it prevents granulomas caused by suture material. The bronchopleural fistulas, serious complications of manual suturing, did not occur. Finally, this method is simpler and rapidly feasible in comparison with classic ones.

Bronchi↗
PubMedDate not supplied

Lung microcytoma: a multidisciplinary therapeutic approach.

This report is of 26 patients diagnosed with microcytoma of the lung in stages I, II, and IIIa. All patients received surgical treatment as well as postoperative chemoradiotherapy when indicated by stage. Mean survival rates were 16 months for stage 1, 10 months for stage II and 6 months for stage IIIa disease. For many years surgery was considered contraindicated in the treatment of pulmonary microcytoma. Now a multidisciplinary approach is being used in which surgery has a crucial role. Microcytoma of the lung has a poor prognosis due to its early metastasis and rapid growth. It is crucial to have early diagnosis and accurate, consistent staging as the basis for treatment. A review of literature shows that the use of surgery, chemotherapy and radiotherapy are all important in treatment of microcytoma. Chemotherapy is successfully utilized preoperatively to improve local control, decrease neoplastic mass, induce histological regression and as postoperative adjuvant therapy. Radiotherapy has been shown to be effective preoperatively to reduce local mass and prophylactically for cerebral metastasis. Surgery is crucial to irradicate the neoplastic mass, improve staging accuracy, decrease the possible selection of neoplastic clones resistant to postoperative therapy, decrease local recurrence and allow less aggressive chemoradiotherapy. We feel the most effective protocol for pulmonary microcytoma includes preoperative chemotherapy and radiotherapy when indicated followed by surgical intervention and finally successive adjuvant therapy. The limited number of our cases does not consent a statistically significative conclusion. Our data confirm the importance of the surgical procedure in stages I and II, where according also to other authors, the best results are obtained. Surgical indication in stage IIIa is still discussed due to precocius lymphnode dissemination that significantly affects long-term survival.

Carcinoma, Small Cell↗
PubMedDate not supplied

[Assessment of exposure to laser radiation in research laboratories].

The problem of laser safety is now topical due to the wide use of laser systems in different working environments. The program of prevention and protection prescribed by law 626/94 gives general rules for the elimination (where possible) and/or reduction of risk factors. For this purpose, it is important to determine the parameters that characterize such risks. The Maximum Permissible Exposure (MPE) and the Nominal Ocular Hazard Distance (NOHD) are the most important parameters of laser safety. The evaluation of these parameters requires a detailed knowledge of the standards and of the various techniques which are necessary to measure them. In particular, the MPE parameters are obtained by CEI EN 60825-1 standard in relation to wavelength and emission duration of the investigated laser. Exposure to laser radiation is usually measured in terms of irradiance (W/m2) or radiant exposure (J/m2). The experimental values of irradiance must be compared with the MPE parameters obtained by safety standards. When the values of irradiance exceed the MPE parameters then the NOHD values must to be calculated. The aim of this paper is to offer a general view of the methods for measuring the above-mentioned parameters for the laser sources that are most widely used in research environments and to compare such parameters with those recommended by safety standards. Our results indicate that for almost all the laser sources analysed, the measured exposure values were greater than the MPE recommended by standards, both for eyes and skin. High values of NOHD indicate that it is necessary to use eye protection, beam stops or attenuators at the end of the useful beam path in normal working conditions and especially in research laboratories in which these conditions can often change.

Humans↗
PubMedDate not supplied

[Pulmonary hamartoma in geriatric surgery].

The pulmonary hamartoma is a kind of disease frequently shown in elderly. The diagnosis is often difficult and fine needle aspiration (FNA) can be used for histological features. CT scan can be also a such useful technique in differential diagnosis. A case is presented and its problems are discussed.

Aged↗