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Biomedical subjects

M Lesiak

Publications and source records attributed to M Lesiak.

10 recordsLinked to original sources
PubMed1992

[Isolated congenital tricuspid valve insufficiency--case report].

A case of congenital, isolated tricuspid regurgitation is reported. A 48 year old woman has been admitted because of shortness of breath and progressive fatigue. Although the heart murmur had been heard in her childhood, the first symptoms appeared when she was 25. One year later she underwent a plastic surgery of tricuspid valve. During the following 20 years she remained asymptomatic, until dyspnea and fatigue developed again. On admission she was cyanotic and positive, systolic jugular venous pulse was seen. Atrial flutter was present and no systolic cardiac murmur was heart. The liver was enlarged without peripheral oedema. Echo-Doppler examination and cardiac catheterisation revealed huge right cardiac chambers and significant tricuspid regurgitation. During reoperation a valve consisting of only two cusps was found with extremely dilated valvular anulus. A Bex valvuloplasty was successfully performed. One month later a control echo-Doppler showed the diminution of right ventricle and right atrium with hardly visible regurgitant jet. The pathogenesis and the course of this extremely rare disease have been also discussed in the paper.

Echocardiography, Doppler↗
PubMed1991

[Heart amyloidosis with enormous cardiomegaly ("the king of hearts")].

A case is presented of a 74 years old man with systemic hypertension, congestive heart failure and history of heart infarction in the past. The physical findings revealed: blood pressure - 130/80 mmHg, arrhythmia and symptoms of congestion in systemic and pulmonary circulation. Ecg tracing showed multifocal atrial rhythm about 90 bpm., very low QRS voltage and lack of R waves in precordial V1-V4. On autopsy an enormous enlargement of the whole heart (1005 g) was found. Microscopical investigation revealed abundant amyloid deposits in the muscle of atria, ventricles and sinus node, disseminated atheromatous changes in the coronary system with no critical narrowing (more than 75% of lumen area). No sings of healed infarct were find. This is the first published case of so called "the king of hearts" due to amyloidosis.

Aged↗
PubMed1991

[Coronary lumen diameter and cardiac mass in various forms of cardiac hypertrophy].

Morphometric evaluation of the epicardial arteries is described in detail in 103 patients with various forms of cardiac hypertrophy. Coronary lumen diameter increases with aging regardless of the cardiac mass. Such an increase is observed in some particular types of cardiac hypertrophy and presumably is caused by the changes of intramuscular vessels and diminished perfusion. In patients with so called myocardial atherosclerosis correlation between coronary lumen diameter age and cardiac mass is opposite. In some forms of cardiac hypertrophy the increment of coronary lumen diameter is accompanied by the increase of the cross sectional area of the artery. In this pattern the increase of lumen diameter is not due to passive vessel dilatation because significant thickening of its wall can be seen. Age appeared to be the most important factor influencing the coronary lumen diameter within the whole population, although this correlation can hardly be seen in patients with "myocardial arteriosclerosis".

Aging↗
PubMed1991

[Comparative evaluation of coronary arteriosclerosis in arterial hypertension and ischemic heart disease. Morphometric analysis of 4062 coronary artery specimens].

We performed a postmortem study on 61 hearts from patients who died of acute ischemic heart disease (IA). Chronic ischemic heart disease (IB) and from hypertensive patients who died of heart infarction (IIA) and other hypertensive complications (IIB). Control group consisted of 16 pts. who died of non cardiac diseases. 4062 coronary artery specimens were estimated. Irrespective of the clinical course of ischemic heart disease the mean percent of coronary artery stenosis was similar in both ischemic groups and significantly higher than in control group. In hypertensive pts. who died of heart infarction it was also significantly higher and similar to ischemic pts. We found the highest percent of segments with critical stenosis in the left anterior descending coronary artery in group IA, IB, IIA. It was also significantly higher in the left main coronary artery in the group of ischemic pts. (IA, IB).

Adult↗
PubMed1990

[Unusual location of mural thrombi in the right atrium caused by pathological changes in the sinoatrial node].

We present a post-mortem examination of two hearts in which we found organized mural thrombi attached to the right atrial endocardium in the recess called antrum atrii dextri. This region is a place where the sinus node is situated very close to the endocardium of right atrium. Any pathological process involving the node (inflammation, degeneration) may reach this part of endocardium by continuity, this in turn creates convenient conditions for mural thrombi formation. The first case--a 52-year old man who died of severe congestive heart failure caused by rheumatic disease with mitral and aortic stenosis. Atrial fibrillation had developed several years before his death. Apart from typical changes of mitral and aortic valves a post-mortem examination revealed an organized, globular thrombus in antrum atrii dextri. In the microscopical findings of the sino-atrial region the fatty degeneration of the sinus node with multiple mononuclear cell infiltration was the most striking feature. The sinus node artery was narrowed due to fibro-muscular dysplasia of its wall. The second case--a 74-years old man who suffered from arterial hypertension and chronic pyelonephritis with a history of heart infarct in the past. The ECG recording showed multifocal atrial rythm with variable P wave morphology and P-Q distance. At necropsy the whole heart was significantly enlarged with no scars or any other signs of healed infarct. The microscopical findings revealed the heart muscle to be infiltrated by amyloid deposits particularly apparent in the sinus node. Similar thrombus of 1.5 cm in diameter was found in antrum of the right atrium.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1987

[Variability in the levels of carotenoids and vitamin A in the blood serum and milk of cows].

Observations of 20 milk cows of the lowland black and white breed were conducted for 14 successive days in four seasons of the year. The age, lactation stages and efficiency of the animals were different. They were divided into two groups: the first with healthy udders (clinically, bacteriologically, cytologically); the second with secretion disturbances and mastitis subclinical. Blood and milk samples were taken every day during the morning milking. The content of carotenoids and vitamin A was determined by the methods of Carr-Price. Although the same feeding and environment conditions of the animals were maintained, the determined levels of the studied components of both body fluids showed a great variation. Significant differences were found between the mean values calculated for individual cows (individual variability). In the milk of cows from group II, a higher concentration of carotenoids and vitamin A was found. It is proposed to assume a physiological minimum of 30 mcg/100 cm3 for vitamin A and of 100 mcg/100 cm3 respectively for carotenoids in blood serum and 100 mcg/100 cm3 and 5 mcg/100 cm3 respectively in milk.

Animals↗