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Biomedical subjects

M Lewis

Publications and source records attributed to M Lewis.

At least 19 recordsLinked to original sources
PubMed1979

Psychotherapy in the residential treatment of the borderline child.

The concept of borderline diagnosis is defined and the goals of residential treatment are delineated. The specific aims and techniques of psychotherapy are then outlined. Concomitant work with parents is utilized. The importance of working through during termination is noted.

Affective Symptoms↗
PubMed1979

Dopamine is a physiological regulator of thyrotrophin (TSH) secretion in normal man.

Using a sensitive and precise radioimmunoassay for human TSH we have demonstrated significant elevations in serum TSH levels in euthyroid volunteers following administration of the dopamine receptor blocking drug metoclopramide when compared with placebo. The degree of TSH response is significantly greater in females than in males and is sustained over a 3-hour period after a single oral 10 mg dose of metoclopramide. The degree of TSH release after metoclopramide is inversely related to the basal TSH level suggesting that dopamine is a determinant of low daytime TSH levels and is thus implicated in the circadian rhythm of TSH secretion. Pretreatment with 10 mg of metoclopramide orally, one hour before TRH administration leads to significant enhancement of the TSH response to TRH. Our findings provide further evidence for the physiological inhibitory role of dopamine in the contol of TSH secretion in normal man. The possible mode of action of dopamine and the clinical implications of this neuroregulatory pathway are discussed.

Adult↗
PubMed1979

Genetic linkage between the Radin and Rh blood group loci.

Lods of +3.89 at a recombination fraction (theta) of 0.10 and recombinant:nonrecombinant counts of 2:16 indicate linkage between the Rd and Rh blood group loci. The possibility that Rd is the same as Sc is discussed.

Blood Group Antigens↗
PubMed1979

Reduction in portal vein blood flow by somatostatin.

Intravenous somatostatin boluses produced striking diminution in portal vein blood flow in dogs (maximally 40--55%). This effect was of rapid onset, without observable changes in hepatic artery flow, systemic blood pressure, pulse or central venous pressure. The duration of action was short, but could be sustained by continuous intravenous infusion. These observations are consistent with an endocrine role of somatostatin in the regulation of nutrient balance.

Animals↗
PubMed1979

Sex and age differences in young children's reactions to frustration: a further look at the Goldberg and Lewis subjects.

This study reports 1-year follow-up data on the children originally observed by Goldberg and Lewis in a barrier frustration situation. Changes in reactions to frustration over a 2-year time span were examined for age and sex differences. Regardless of sex, over the first 2 years of life, barrier frustration was responded to with a decrease in stress and an increase in problem-solving behavior. The data suggest that sex differences in success at coping with the frustration may change with age and may be dependent on what behaviors are considered to be more instrumental in solving the frustration. Sex differences related to behavior in the barrier frustration were highly age specific. As previously reported in Goldberg and Lewis, at 1 year of age boys cried less and made more active attempts to get around the barrier than girls. However, at 2 years of age, girls vocalized more for help from the mother and made more attempts at problem solving than boys.

Adaptation, Psychological↗
PubMed1978

Oxamniquine in the treatment of various schistosome infections in South Africa.

Trials of a new schistosomicide oxamniquine (Vansil) were carried out in the lowveld of the Eastern Transvaal. After initial dose-finding trials, the safety and efficacy of oxamniquine against Schistosoma mansoni at an oral dose of 15 mg/kg twice a day for 2 days (total dose 60 mg/kg), were confirmed. No detectable effect was noted against S. haematobium or S. mattheei.

Adolescent↗
PubMed1978

Rh isoimmunization during pregnancy: antenatal prophylaxis.

Of 3533 Rh-negative women who began a pregnancy without detectable Rh antibodies, 62 (1.8%) demonstrated evidence of Rh isoimmunization during pregnancy or within 3 days after delivery. All denied transfusions as well as abortions or previous pregnancies not followed by the administration of Rh immune globulin. Rh isoimmunization during pregnancy or within 3 days after delivery, which will not be prevented by the administration of Rh immune globulin after delivery, is the most important cause of residual Rh isoimmunization. A clinical trial of antenatal administration of Rh immune globulin, initially at 34 weeks's and subsequently at 28 and 34 weeks' gestation, in 1357 Rh-negative pregnant women who were delivered of Rh-positive babies, was effective in preventing the development of Rh isoimmunization during pregnancy or within 3 days after delivery. Antenatal prophylaxis with Rh immune globulin will be necessary if the incidence of Rh isoimmunization is to be reduced to its lowest possible level. Antenatal prophylaxis at 28 weeks' gestation is now an insured service in Manitoba.

Antibody Formation↗