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Biomedical subjects

M Lidji

Publications and source records attributed to M Lidji.

7 recordsLinked to original sources
PubMed1988

Therapy with nifedipine in asthma: a randomized double-blind crossover trial.

A randomized double-blind crossover trial with nifedipine (10 mg orally four times a day for 2 weeks) was carried out in 11 asthmatic patients. The analysis of the differences between the periods of running-in, placebo and nifedipine administration showed a mild improvement in symptom scores during the nifedipine period (2.8 +/- 1.5, 2.8 +/- 1.8 and 2.1 +/- 1.6, respectively; P less than 0.05). Drug intake and peak expiratory flow rates remained unchanged. This suggests that the drug did not influence the baseline bronchial tone, but might have attenuated some superimposed exacerbations due to unavoidable exposure to cold, effort or allergens. We conclude that the benefit of orally administered nifedipine in low doses has little value in the treatment of asthma.

Adult↗
PubMed1987

Salbutamol versus atropine. Site of bronchodilatation in asthmatic patients.

The site of bronchodilatation produced by inhaled salbutamol (0.045 mg/kg) versus atropine (0.035 mg/kg) was investigated in 14 asthmatic young patients. No significant difference was found between the effects of the drugs on any of the large- or small-airway tests in those patients in whom bronchodilatation originated mainly in the large airways or when all patients were considered together. In those patients, however, in whom the small airways made the major contribution to the total airways resistance, atropine produced a higher increase in specific conductance, in maximal flow at all lung volumes and in density dependence of flow, but only the specific conductance showed a significant difference between the effects of the two drugs (p less than 0.01). It was concluded that in these patients atropine produced more bronchodilatation than salbutamol in both central and peripheral airways. These findings do not confirm previous studies which suggested that in asthmatic patients, as in normal subjects, atropine produces mainly central bronchodilatation, while salbutamol produces mainly peripheral bronchodilatation. The difference in doses, route of administration, time response and in the pretreatment severity and site of bronchodilatation could account for the disagreement between previous studies and the present one.

Adolescent↗
PubMed1981

The influence of endotoxin-induced pyrexia on the pharmacokinetics of gentamicin in the rabbit.

Endotoxin-induced pyrexia caused a 2-fold increase in the volume of distribution of intravenously administered gentamicin in the rabbit as compared to the basal state (0.13-0.23 and 0.31-0.65 l for the central and peripheral compartments, respectively). Elimination, half-life was prolonged (46 to 90 min control and pyrexia, respectively), total plasma clearance remaining unchanged (4.6 and 4.9 ml/min, respectively). Endotoxin-induced pyrexia caused a significant increase in the serum concentrations and area under the concentration-time curve of gentamicin administered intramuscularly (355 to 704 microgram . min/ml, control and pyrexia, respectively). The increase in gentamicin concentration area under the curve was positively correlated with the temperature load (P less than .01). As total plasma clearance was not affected by pyrexia, the increased serum concentrations after intramuscular injection may be explained by enhanced absorption from the site of administration.

Animals↗
PubMed1978

Bacterial endocarditis on a prosthetic valve. Oral treatment with amoxicillin.

A patient with endocarditis due to Streptococcus faecalis on an aortic valvular prosthesis was successfully treated using large oral doses of amoxicillin concurrently with intramuscular administration of streptomycin. Oral therapy was employed because of a persistent reaction to intravenously administered antibiotics. Oral therapy for bacterial endocarditis occurring on an artificial valve may be attempted as a last resort when all other accepted therapeutic measures have failed.

Administration, Oral↗