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Biomedical subjects

M Liebhart

Publications and source records attributed to M Liebhart.

At least 19 recordsLinked to original sources
PubMed2000

[Results of treatment of osteosarcoma in children according to the SFOP-94 protocol in the experience of the Polish Paediatric Solid Tumour Study Group].

Between April 1994 and December 1999, 34 children aged from 5 to 20 years (23 females and 11 males) suffering from osteosarcoma, were treated according to the SFOP-94 protocol. The primary preoperative chemotherapy consists of adriamycin and high-dose methotrexate administration. There were 28 patients with non-metastatic tumours of the extremities and 6 children presented disseminated disease with pulmonary metastases. The primary localization included femur - 20 patients, tibia - 9 patients and humerus - 5 patients. In 26 patients limb-salvage surgery was applied. The programme of chemotherapy was changed in 4 children because of toxicity of methotrexate (1 patient) and progression of disease (3 patients). 26 out of 34 (76,5 %) children are alive including 24 out of 28 patients with localized disease. EFS calculated according to Kaplan-Meier analysis was 60 % at 67 months.

Adolescent↗
PubMed2000

[Results of treatment in osteosarcoma--chemotherapy with ADM and CDDP].

Malignant bone neoplasms contribute to about 7% of paediatric cancer. Within the last 20 years much has changed in cancer treatment. Neoadjuvant chemotherapy, as the first phase of comprehensive treatment, results in regression of the tumour and makes limb salvage surgery possible. An exact analysis of 36 patients with osteosarcoma of different localisation, treated at the National Research Institute of Mother and Child between 1991 and 1996 was carried out. Treatment was started with pre-operative adjuvant chemotherapy with ADM and CDDP, administrated during 6 weeks. The regimen and the length of administration depended on stage of disease and tumour reaction to chemotherapy. Amputations or limb salvage surgery was conducted as a second phase of therapy. Postoperative chemotherapy was given for 6 months. Tumour reaction to chemotherapy was described according to the Huvos scale - percentage map of necrosis and regression areas in the neoplastic tissue. The analysis shows good results after chemotherapy with ADM and CDDP.

Adolescent↗
PubMed1998

[The analysis of failures in therapy of osteosarcoma in children treated according to SFOP-94 protocol in the studies of Polish pediatric solid tumors treatment group].

Between December 1989 and April 1998 twenty eight children aged from 5 to 20 years (18 female and 10 male) suffering from osteosarcoma were treated according to the OS-SFOP-94 protocol. Twenty four patients presented with localized tumor of extremities and four with pulmonary metastases. The majority of primary tumors exceeded 150 ml of volume. The primary preoperative chemotherapy consisted of adriamycin (70 mg/m2 every four weeks) and high-dose methotrexate (12 g/m2 every week). In 20 patients limb-salvage surgery was applied, in three children--amputation and in one child tibia resection with genu arthrodesis was applied. Five of 28 patients died, one because of treatment related infection, 2 non-responders with metastatic osteosarcoma due to progressive disease, and one because of local relapse with pulmonary metastasis non-responding to therapy, one because of treatment refusal. Twenty one from 25 children are alive from 5 to 51 months. Event frae survival of children with localized disease calculated according to Kaplan-Meier analysis was 64.17% in the 51st month. The main cause of failure in the treatment of osteosarcoma in children is primary and secondary progression of disease. The toleration and results of treatment for osteosarcoma in children according to the OS-SFOP-94 is satisfactory.

Adolescent↗
PubMed1998

[The role of local surgical and radiological control in the treatment of soft tissue sarcoma sensitive to chemotherapy in children. Report of Polish Pediatric Solid Tumors Treatment Group].

In this paper the role local surgical and radiological control in the treatment of soft tissue sarcomas in children was analyzed. All children were treated according to CWS-91 and SIOP-IV protocols. Eighty three children with RMS A + E, EES/PNET, SS, UDS were included in the analysis. The primary surgery consisted of R0 (5%), R1 (18%) or R2 (16%) resection. In majority of cases (61%) primary surgical intervention was limited to diagnostic biopsy. Conventional or hyperfractionated radiotherapy was performed in 42.8%, 73.8% and 75% of children with disease stage II, III and IV, respectively. Delayed surgery was performed in 20 out of 53 (37.7%) children with stage III of the disease. In 5 patients without primary focus (urinary bladder in 3 and prostate in 2 cases) removed, progression of the disease occurred. In 5 children (stage IV) with progression of the disease no secondary surgery was performed. In 4 of them the primary tumor exceeded 10 cm in diameter. No delayed surgery was performed in 69% of relapsed children with stage III of the disease. Planned radiation therapy was not performed in 15.9% of cases. Primary local surgical control of primary tumor is of great importance for remission duration. In children who underwent delayed surgery the estimated EFS was of 0.7, in comparison with 0.5 EFS of those without secondary surgical treatment.

Adolescent↗
PubMed1995

[Prognostic factors in neuroblastoma in children].

The paper presents the review of prognostic factors which were investigated from the first interests of neuroblastoma, as a model for cancer biology in pediatric oncology. The authors on the basis of other authors experiences and on the own observations, as well stress the importance of basic sciences from the field of molecular biology, cytogenetics and biochemistry, leading to better understanding of the nature of neuroblastoma and to introduction of rational treatment. The stratification of neuroblastoma patients according to the known prognostic variables influenced favourably treatment results.

Biomarkers, Tumor↗
PubMed1990

[Morphologic examination of ovaries and liver after repeated administration of cyclophosphamide in therapeutic low doses to immature experimental rodents in various stages of individual maturity].

Liver and ovarian tissue samples of the immature healthy Wistar rats were examined histologically after administration of the repeated low doses of cyclophosphamide. The youngest experimental group was at the age of 7/14 days. Morphologic examination involved histochemical, histoenzymatic, morphometric and ultrastructural techniques. The observed changes in the liver tissue were minimal and totally reversible at time of animals maturity. Pathomorphological changes in ovaries were more evident and complex, concerning all structures of the gland. The dominant features of the damage included the disturbances of the physiological morphological maturation and the widespread hyperluteinization of all structures. In spite of the morphological changes, the activity of the hydroxysteroid dehydrogenases in ovaries remained unchanged.

Animals↗
PubMed1989

[Deep fascicular fibromatoses in diagnostic material from the pathomorphology department of the Institute of Mother and Child].

We studied 17 cases of deep fascicular fibromatoses of various location in children and adolescents from 7 months to 16 years. Basic proliferative cells consisted of mature cells of the connective tissue slightly changed cytologic features but without atypia. We observed scanty regular mitoses. Histological structure of individual tumours and fields in the same tumours differed in the degree of collagenization, vascularization and abundance of cells. In four cases proliferations were differentiated with neurofibromatosis, in one case with fibrosarcoma of high-degree differentiation. In four cases the tumours were of desmoid structure. In two cases of mesenteric location of the proliferation we found foci of cartilagous metaplasia, which in one case after several recurrences transformed the tumour into a chondrosarcoma.

Adolescent↗
PubMed1989

[Comparative histopathologic analysis of osteogenic sarcomas before and after initial chemotherapy].

We performed comparative histopathologic analysis of sections from diagnostic biopsy and surgical material obtained after antineoplastic chemotherapy. The sections were taken from 20 osteogenic sarcomas found in children and adolescents aged from 3 to 17. Chemotherapy used between samplings was based mainly on Adriamycin, and in four cases Methotrexate. Most frequent changes in histologic structure of the tumours after chemotherapy included further development of necrosis, a reduction of the structural homogeneity of the tumours and enhancement of cellular polymorphism. In many tumours we found enhancement or development of abilities to form cartilaginous foci. We did not observe maturation of the neoplasm induced by chemotherapy in the form of the development of highly differentiated bony tissue. The above-mentioned changes could be defected 3 to 4 weeks after chemotherapy initiation.

Adolescent↗
PubMed1989

[Malignant neoplasms and potentially malignant hyperplasia in children and adolescents from material at the Department of Pathomorphology, Institute of Mother and Child during 1978/79-1983].

531 cases of malignant neoplasms and potentially malignant hyperplasia in children and adolescents diagnosed in the Department of Pathomorphology, Institute of Mother and Child between 1978/79 and 1983 are presented. Only patients treated in this hospital were included into the study. The most common diagnoses were neuroblastoma (68 cases), rhabdomyosarcoma (62 cases), nephroblastoma (56 cases), osteogenic sarcoma (47 cases), non-Hodgkin lymphoma (41 cases). Besides neoplasms most typical for childhood and adolescence the rare less typical cases were also seen.

Adolescent↗
PubMed1984

[Histoenzymatic study of postnatal development of the rat ovary, follicular atresia and interstitial gland].

In our experiment, we investigated histoenzymatic activity od postnatal development of rat ovary, specially the main metabolic process--steroidogenesis. We noticed, that during early folliculogenesis great amount of follicles are eliminated by atresia. Atresia also plays very important role in forming of interstitial gland. Interstitial gland which is found in ovary of 14 days old rat ovaries, morphologically and enzymatically differs from the structure observed on older animals. We concluded, that ovary of 14 days old rat is not developed but ovary of 21 days old rat seems to be morphologically and histochemically well developed.

Aging↗
PubMed1982

[Comparison of the biosynthesis of ovarian and placental steroid hormones].

The main principles of the ovarian steroid hormones synthesis are discussed on the basis of recent literature. The role of special cell lines in the ovarian synthesis also the differences concerning steroidogenesis of the foeto-placental unit are pointed out. In the foeto-placental steroidogenesis the detailed role of trophoblastic syncytium and foetal organs are shown.

Androgens↗