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Biomedical subjects

M Lim

Publications and source records attributed to M Lim.

117 records · Page 7Linked to original sources
PubMed1983

Prevention of experimental allergic encephalitis with in vivo administration of anti I-A antibody. Decreased accumulation of radiolabelled lymph node cells in the central nervous system.

Experimental allergic encephalitis (EAE) can be prevented with the in vivo administration of monoclonal anti I-A antibody. A radiometric assay was developed to measure the accumulation of lymphocytes in the central nervous system of EAE animals. A direct correlation was observed between severity of clinical disease and the amount of radiolabelled lymph node cells (LNC) in the central nervous system. Injection of anti I-A antibody in vivo prevented clinical EAE and decreased the accumulation of radiolabelled LNC in spinal cord after immunization with mouse spinal cord homogenate and adjuvants.

Animals↗
PubMed1982

Continuous intravascular monitoring of epinephrine-induced changes in plasma potassium.

Ion-selective electrode catheters were used for continuous monitoring of epinephrine-induced changes in plasma potassium in different parts of the circulation of anesthetized greyhounds. Bolus injections and continuous infusions of epinephrine produced dose-related changes consisting of an initial transient increase followed by a decrease to levels below control. The latter part of the response was relatively short-lived in the case of bolus injections, but when the epinephrine was administered by continuous infusion, a progressive fall was maintained for the duration of the infusion. During the period when potassium levels were undergoing an acute change, marked differences were seen between concentrations in different parts of the circulation. Further studies are needed to delineate the incidence and extent of similar changes in humans, and their significance in producing dangerous dysrhythmias.

Animals↗
PubMed1982

Continuous intravascular monitoring of plasma potassium using potassium-selective electrode catheters.

A fast-responding, potassium-selective electrode catheter suitable for continuous intravascular monitoring is described. Traces illustrating its performance in human patients and anesthetized greyhounds are shown. There was no significant difference between off-line blood samples analysis (using an in vitro electrode) and results obtained with the in vivo electrode; mean absolute difference was 0.11 +/- 0.11 (SD) mM. The technique described is simple and reliable, and represents an advance on existing intermittent sampling methods for detailed monitoring of rapid changes in plasma potassium.

Animals↗
PubMed1982

Early changes in plasma potassium after acute alterations in PaCO2 in anesthetized dogs, monitored continuously with intravascular potassium-selective electrodes.

Changes in plasma potassium in the first 10 min after alterations in PaCO2 in anesthetized greyhounds were monitored continuously in vivo with potassium-selective electrode catheters. Elevation of PaCO2 resulted in a small transient fall in plasma potassium whereas reduction in PaCO2 resulted in a small transient rise in plasma potassium. Maximum changes occurred at approximately 5 min after alterations in PaCO2 with levels tending to return to control thereafter. Changes of similar magnitude in normal man would not be expected to have an adverse effect on cardiac function, but they may have greater significance in subjects with pre-existing abnormal potassium levels, during concurrent treatment with digoxin, and after sudden alterations in PaCO2 in chronic hypo- or hypercapnic conditions.

Animals↗