PubMed Health⌕ Search

Biomedical subjects

M Lindström

Publications and source records attributed to M Lindström.

64 records · Page 4Linked to original sources
PubMed1986

Metabolism of cholate, 7 beta-hydroxy- and 12 beta-hydroxy-isocholates in the rat.

The three epimeric trihydroxy bile salts cholate (C), 7 beta-hydroxy-(7 beta) and 12 beta-hydroxy-(12 beta) isocholate were fed to rats by intubation or in the diet. All three bile salts were well absorbed 7 beta greater than C greater than 12 beta and underwent heavy biotransformations in the enterohepatic circulation 12 beta greater than 7 beta C. The result is a low concentration of unchanged administered bile salt in the bile salt pools, 12 beta less than 7 beta less than C, the percentage figures being 3, 20 and 35%, respectively, after 7 days feeding. In spite of this, the composition of the bile changes, less phospholipid and cholesterol being excreted in the bile per mumol bile salt after feeding, 7 beta and 12 beta compared to C. No significant increase in the faecal fat was seen in rats fed the beta-hydroxy bile salts. Only minor amounts of the radioactivity from the beta-hydroxy bile salts were secreted into the urine, and no more when compared to C.

Animals↗
PubMed1986

Effects of feeding ursocholic acid to germfree rats.

Germfree rats were fed 24-14C-ursocholic acid (UC) mixed into the diets for 10 days. The bile was then drained by cannulation for 6 hours to collect the bile salt pool. No biotransformation of the labelled UC occurred and it constituted approximately equal to 75% of an enlarged bile salt pool. Less phospholipid and cholesterol were secreted into the bile per mumol bile salt compared to normal rats. The critical micellar concentration (CMC) of the bile was determined by equilibrium dialysis and found to be increased. Faecal excretion of labelled triolein added to the diet was unaffected by feeding ursocholic acid. Excretion of 14C-octadecane and 14C-cholesterol increased significantly under the same conditions. Ursocholic acid feeding thus resulted in a selective malabsorption of octadecane and cholesterol.

Animals↗
PubMed1984

Chemosensitivity tests by a miniclone technique.

A modified miniclone method has been adopted to tissue culture testing of sensitivity to cytostatic drugs. The technique permits detailed microscopic clonal analysis of multiplication of single cells under conditions of 100% plating efficiency of certain selected established tumor lines or normal cells. Three different response parameters were distinguished--cytolysis, cytostasis and replicative capacity of cell fraction capable of multiplication. Notable differences were found among the five drugs tested--adriamycin, alkeran, BCNU, platinol and streptozocin.

Antineoplastic Agents↗
PubMed1981

Aqueous lipid phases of relevance to intestinal fat digestion and absorption.

The phase behavior of monoglyceride/water systems, with oleic and linoleic acid as the dominating fatty acid residues, was investigated. Increased solubilization of triglycerides (oil) or oleic acid in the cubic liquid-crystalline phase formed by monoglyceride and water resulted in the formation of a reversed hexagonal liquid-crystalline phase followed by an L2-phase. The liquid-crystalline phases have different dispersion properties compared to each other in dilute micellar bile salt solutions. The cubic phase is found to be easily dispersed. The relevance of aqueous lipid phases other than micellar is discussed in relation to intestinal lipid digestion and absorption.

Bile Acids and Salts↗
PubMedDate not supplied

School phobia with separation anxiety disorder: a comparative 20- to 29-year follow-up study of 35 school refusers.

The outcome of school phobia after age 30 years was studied with the hypothesis that school phobia cases would have persisting psychiatric problems, but would function better than nonschool refusal psychiatric patients. The subjects consisted of three groups. Thirty-five individuals treated for school phobia at ages 7 to 12 years were compared with age- and sex-matched nonschool refusal child psychiatric patients (n = 35) and a sample from the general population (n = 35). School phobia cases had had more psychiatric consultation, lived with their parents more often than the general population group, and had fewer children than both comparison groups. The nonschool refusal child psychiatric patients had poorer psychosocial adjustment and higher rates of criminal offenses. The implications of the findings are discussed.

Adult↗
PubMedDate not supplied

Inactivation of Myc-induced p53-dependent apoptosis in human tumors.

The Myc family of oncoproteins promote cell growth and are frequently overexpressed in human tumors. However, Myc can also trigger cell death by apoptosis. This is at least in part mediated via the ARF-p53 pathway. Myc activation leads to a selection for inactivation of ARF or p53, allowing cell survival and tumor progression. Restoration of p53-dependent apoptosis by various means is an attractive approach for new cancer therapy.

Apoptosis↗