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Biomedical subjects

M Link

Publications and source records attributed to M Link.

At least 73 records · Page 4Linked to original sources
PubMed1981

High-dose methotrexate in osteogenic sarcoma adjuvant chemotherapy and limb salvage results.

This communication provides a description and update of the three adjuvant regimens utilized at the Sidney Farber Cancer Institute. The disease-free survivals are: Study I--42% at 4 years; Study II--58% at 3 years; and Study III--currently 78%. In the limb salvage experience, among the evaluable patients, 6 of 12 treated with preoperative chemotherapy are disease free (median 32 months) and 12 of 14 (86%) treated without preoperative chemotherapy are disease free (median 13 months).

Amputation, Surgical↗
PubMed1981

[Free fat in amniotic fluid - a criterion for prenatal assessment of foetal maturity (author's transl)].

Smears were made and stained with nile-blue sulphate following sedimentation of 235 amniotic fluid samples which had been obtained by amniocentesis. An assessment was made of the amount of free fat and of the various cell shapes involved. Free fat was found to occur in higher quantity in advanced pregnancy. These data were compared with postnatally estimated pregnancy age. The method proved to enable objective assessment of foetal maturity over the last weeks of pregnancy, and it seemed to be very useful in differentiating between hypotrophy and immaturity.

Amniocentesis↗
PubMed1981

[Importance of electroconisation in diagnosis and therapy of precursory and early forms of cervical carcinoma (author's transl)].

Conisation is the optional method by which to elucidate suspicious cytological findings. Diagnostic and therapeutic electroconisation is the subject of this paper. The report is based on 1,132 electroconisations. Histological tissue assessment was in no way impaired in more than 98 per cent of all cases. Anatomic results were excellent. The method is characterised by little effort and high speed. Histologically, lesioned tissue was removed from among "intact tissue area" in 71 per cent of all cases of carcinoma in situ and in 43 per cent of all cases of microcarcinoma. In many cases, electroconisation was chosen for definite therapy.

Biopsy↗
PubMed1981

[Delivery following caesarean section (author's transl)].

Studies were conducted into variants of delivery and perinatal mortality following caesarean section, between 1957 and 1979, at Landesfrauenklinik of The Medical Academy of Magdeburg. The number of deliveries following caesarean section went up from 0.35 per cent, between 1957 and 1961, to 1.20 per cent, between 1967 and 1979. The rate of repeated caesarean sections decreased from 97.3 to 29.3 per cent. Unambiguous decline in perinatal mortality was reflected in a drop from 6.5 per cent, between 1957 and 1961, to 1.4 per cent, between 1967 and 1979.

Cesarean Section↗
PubMed1980

[Nuclear-medical testing of retrograde tubal transport mechanism for sterility diagnosis (tubal isotope test TIT) (author's transl)].

Pathological change of the tube is one of the most common causes of female sterility. While mechanical occlusion can be identified by the techniques of tube examination so far in use, tubal function can hardly be assessed by means of them. Described and evaluated in this paper is a test method recently devised in nuclear medicine for the assessment of tubal function.

Fallopian Tube Patency Tests↗
PubMed1980

[Atypical hyperplasia of endometrium -- prognostic trends and therapy (author's transl)].

Atypical hyperplasia of the endometrium was histologically diagnosed in 111 cases at the Gynaecological Hospital of the Medical Academy of Magdeburg, between 1970 and 1976. The cases were defined by three degrees of severity. The need for group differentiation and appropriate therapeutic consequences was established by means of follow-up checks of the above cases. Progressing courses were recorded from 6.9 per cent of the cases in Group I, 13.95 per cent in Group II, and 24.0 per cent in Group III. Hysterectomy was recommended for all persistent and progressing findings in Groups II and III, while long-term supervision was found to be necessary in cases of regression. Sexually mature women with atypical hyperplasia should receive gestagens, between the 16th and 24th days following menstruation, before diagnostic abrasion is applied.

Adult↗
PubMed1980

[Applicability to abrasion material of in vitro autoradiography, using 3H-thymidine (author's transl)].

The applicability of in vitro autoradiography, using 3H-thymidine, was tested on material obtained from gynaecological abrasion. Included were 161 abrasion samples obtained from 151 patients, and 88 per cent of them proved evaluable by autoradiography. The use of in vitro autoradiography was found to give no additional gain in information for biological assessment. Index testing by means of in vitro autoradiography failed to prove worthwhile unless it came to examination of polyps or of glandular-cystic hyperplasia or of effects exerted on the endometrium by ovarian tumours with sizeable hormonal activity. Endometrium was found to be a kind of tissue characterised in both intact and pathological condition by pronounced individual age-dependent and cycledependent variations of its marking indices.

Autoradiography↗
PubMed1980

[Comparative morphological and functional studies on infertility of males (author's transl)].

Male infertility is common. It usually is attributable to impaired maturation of germinal cells. The causes are related to the following factors: 1. Defective development of the gonadal ridge; 2. Abnormality of chromosomes; 3. Disorders in pituitary function; 4. Exogenous effects; 5. Unknown aetiology. -- Differentiation is difficult between those causes which often cannot be discovered at all. Therefore, assessment of male infertility is undertaken with reference to findings obtained from seminal, histological, immunological, cytogenetic, and hormonal tests as well as from electron microscopy.

Humans↗
PubMed1979

[Results of testicular biopsy in azoospermia].

The causes of male infertility generally fall into three categories: pretesticular, testicular and posttesticular causes. The pretesticular causes are extragonadal endocrine disorders, such as those originating in the pituitary or the adrenals, which have an adverse effect on spermatogenesis. The testicular causes of infertility are conditions in which the primary defects reside in the testes. The posttesticular causes of infertility consist mainly of obstructions of the ducts leading away from the testes. Testicular biopsy is an important method in the diagnosis and management of male infertility.

Biopsy↗
PubMed1977

[Breech presentations in 1957-1961 and 1967-1975 at the Landesfrauenklinik Magdeburg].

Breech presentation is classed as an abnormality because of the high associated perinatal mortality and morbidity rates and the slightly increased maternal morbidity. A review of 14 years' experience with breech delivery was undertaken to ascertain patterns of care. During this period there were 33 183 births and there were 1271 cases of breech presentation. The method of delivery in the 1271 cases included 91,5 per cent vaginal deliveries and 8,5 per cent cesarean sections. There was an increase to 15,3 per cent during the last 2 years of the review. This review indicates a decline in perinatal mortality rate from 20,3 to 5,4 per cent (unselected). Breech presentation is often associated with premature labor. Premature labor represents the significant clinical problem by contributing to perinatal morbidity and death.

Breech Presentation↗
PubMed1977

[Value of testicular biopsy in the diagnosis of sterility].

Male infertility is a far more prevalent problem than is perhaps generally realized. The evaluation of testicular biopsies allows various clinical syndromes of hypogonadism to be identified and a rational basis for therapy to be established. The morphological-anatomical classification of male infertility paralleling the clinical-biochemical classification divides the different varieties of male infertility into three categories: those due to pretesticular, testicular, and posttesticular causes. Testicular biopsy is an important method in the diagnosis and management of male infertility. The procedure is simple and safe in competent hands and yields information obtainable in no other way. The increasing use of this procedure permitts a rational classification of the testicular lesions responsible for infertility and provides an intelligent basis for the institution of corrective measures or the withholding of therapy in cases in which the biopsy indicates a hopeless prognosis for fertility.

Biopsy↗
PubMed1977

[Delivery in adolescents].

The course of delivery to patients aged 16 and under during 1957 to 1961 and 1967 to 1971 is reported. The frequency of deliveries has not changed. Vaginal delivery occurred in 140 of 142 patients. The delivery of the young girls was characterized by an uncomplicated course. The incidence of breech, cesarean section and assisted deliveries was low. Neonatal complications and the perinatal mortality rate are attributed to prematurity and malformation. Prematurity might be reduced by an intensive care of pregnancy.

Adolescent↗
PubMed1977

[Value of needle biopsy in the diagnosis of gynecologic carcinoma recurrence].

There are many difficulties in the diagnosis of recurrent carcinoma in the lesser pelvis. A second course of radiation carries a high risk of morbidity and mortality. Therefore histological proof of recurrence must be obtained prior to subjecting a patient to radiotherapy. An attempt has been made to demonstrate malignant recurrence on the pelvic side wall by means of needle biopsy. The results of 181 needle biopsies are reviewed and the sources of error in this method are discussed.

Biopsy, Needle↗
PubMed1976

[The cervical cycle as shown on the example of morphological examinations in pregnancy with special reference to subcylindrical vacuolization].

Cyclic alterations of the endometrium are known for certain, but similar processes of the mucous membrane of the uterine cervix are vague. In pregancy there is a considerable increase in secretion. The epithelium of surface and glands becomes stratified and the nuclei of cylindrical epithelial cells withdraw from the base of the cells and often originate retronuclear vacuols. From these vacuols one has to distinguish so-called subcylindrical vacuols which only appear during pregnancy. They are seen between epithelium and basal membrane. Electron microscopical investigations show the vacuols lined partly by atrophical partly bysecretory cylindrical cells. Histochemically the contents of the vacuols are similar to the cytoplasm of cylindrical cells and the contents of glands. These alterations of the cervical mucous membrane are dependent on hormonal stimulation and in conclusion it must be possible to demonstrate the hormonal situation andits disturbances by investigations of the mucous membrane of the cervix uteri.

Cervix Uteri↗
PubMed1976

[Pregnancy in adolescents].

The course of pregnancy to patients aged 16 and under during 1957 to 1961 and 1967 to 1973 is reported. There is an increasing number of pregnancies in these groups of adolescent girls. The frequency of delivery has not changed but the number of abortion has become more important. This fact and the complication by a substantially higher frequency of gestosis and by a tendency to premature delivery causes the pregnancy in young girls as a high risk pregnancy which needs intensive care.

Abortion, Induced↗
PubMed1976

[Current organizational and clinical aspects of sterility and infertility].

It is reported about an organizational plan for more intensity in the field of medical care and research of sterility and infertility. Diagnosis and therapy of sterility should be carried out within a high specialised centre. General practitioner and gynecologist in general and clinical practice of the territory have to accomplish important problems in prophylaxis and metaphylaxis of sterility and infertility.

Ambulatory Care↗