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Biomedical subjects

M Linquette

Publications and source records attributed to M Linquette.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Is age a prognostic factor in differentiated carcinoma of the thyroid gland? (author's transl)].

Reviewing the outcome of 82 patients with differentiated carcinoma of the thyroid gland operated upon and followed up for more than 5 years, the authors were unable to find any difference between "younger" *under 45) and "older" (above 45) patients. They wonder whether the poorer prognosis of differentiated thyroid gland carcinoma in older patients could be due to to the tumour being usually more advanced in such patients at the time of diagnosis rather than to age itself. II this were the case, there would be no need to tailor the operative procedure to the patient's age.

Adenocarcinoma↗
PubMed1981

Antibody inducing lymphocyte cytotoxicity (ADCC) and lymphocyte-mediated cytotoxicity in auto-immune thyroid diseases.

Addition of heat-inactivated serum from patients with autoimmune thyroid diseases to normal nonadherent human lymphoid cells caused significant lysis of thyroglobulin or crude thyroid extract-coated erythrocytes. Serum from 9/10 patients with Hashimoto's thyroiditis induced significant chromium release by normal lymphocytes at higher dilution (greater than 1 : 1 000) than in other thyroid diseases, the mean highest positive dilution being 1 : 535 in Grave's disease and approximately 1 : 200 in primary hypothyroidism, hyperthyroidism without exophthalmos and non toxic goitres. Lymphocyte-mediated cytotoxicity in the absence of serum was found positive on one half of the patients with lymphocyte-dependent antibody. Besides an appraisal of autoimmunization in thyroid diseases, such cell-mediated reactions may indicate how the gland is damaged in autoimmune thyroid diseases.

Adolescent↗
PubMed1980

[Non-hormonal therapy for menopausal disorders: results of a multicentric double-blind trial (author's transl)].

A multicentric trial was conducted under double-blind conditions to assess the efficacy of veralipride in the treatment of menopausal disorders, when compared with placebo. Excellent or good results were obtained in 32 of the 40 patients (80 p. cent) with sudden flushes, after veralipride treatment, and only 17 of the 35 patients (48,5 p. cent) after placebo. In spite of the remarkable sensitivity of these disorders to placebo administration, the results are highly significant (p < 0-01) in favor of veralipride. Successful results after veralipride were more frequently noted in cases of natural menopause (21 out of 23 cases = 91,3 p. cent) than those with an artificial menopause (11 out of 17 cases = 64,7 p. cent). In psycho-functional disorders (anxiety, irritability, depressive syndrome), veralipride gave excellent or good results in 17 out of 32 cases, placebo in 8 out of 31 cases, a significant difference in favor of veralipride (p < 0,05). No significant modifications in biological parameters studied were noted, and only 2 cases of mild galactorrhea and mammary congestion were observed, though not reported by the patients. One patient complained of vertigo. Veralipride appears, therefore, to be the first non-hormonal therapy effective against disorders of the climateric.

Adult↗
PubMed1980

[Thyroid autonomous nodule. Surgical treatment and postoperative outcome, retrospective study of 102 cases (author's transl)].

Follow-up of 102 patients operated upon for autonomous thyroid nodules is reported. Retrospective study of operative findings and aftermath of surgery clearly demonstrates that the patho-physiological concept of autonomous nodule does not snugly fit practical problems experienced with the management of such patients. The autonomous nodule can be a malignancy. Ipsilateral thyroid lobectomy seems more suitable than nodulectomy. Gross appearance of the thyroid remnant makes sometimes post-operative hormonotherapy unexpectedly advisable. From a theoretical point of view, post-operative thyroid scan, TSH assay and TRH test are mandatory, to assess recovery.

Adolescent↗
PubMed1980

[Test of pituitary adrenal suppressibility with I.V. dexamethsaone in the diagnosis of Cushing's syndrome (author's transl)].

The authors report a pituitary adrenal suppressibility test, using a 4 h IV infusion of dexamethasone phosphate (4 mg). Plasma cortisol is measured before and at the end of the infusion. The results allow a good discrimination between Cushing's disease (bilateral adrenal hyperplasia: 9 cases) and Cushing's syndrome of tumorous origin (adrenal tumors 7 cases, ectopic ACTH syndrome 3 cases, hypophyseal adenomas 2 cases), only bilateral adrenal hyperplasia cases are lowering significantly.

Adrenal Cortex↗
PubMed1980

[Systematic or selective frozen sections during surgery for suspected malignant thyroid lesions? Results in 674 cases over a period of 6 years (author's transl)].

Results of a retrospective study of 674 frozen sections in thyroid surgery, demonstrated on over all reliability of 98.2%, when compared with final pathological findings, with 651 confirmation in 674 cases. False negatives of malignancy represented 1.6% of lesions thought to be benign, while false positives were obtained in 4.8% of lesions thought to be malignant on frozen sections. Prior to frozen sections, 221 patients had needle punctures and cytological smears studies of the thyroid lesion. When comparing the results after using the two methods, no false positive for malignancy, assessed by cytology, was found on frozen sections, which also corrected but two false negatives of malignancy given by the 177 smears affirmative of benignancy, but reduced the number of equivocal results of cytology from 36 to 1. Both pre-operative cytological examination by needle puncture and intra-operative frozen sections appear, therefore, to be very reliable methods for studying thyroid lesions. Frozen sections are complementary to cytological studies. These results suggest that, in surgical thyroid diseases, frozen sections, need perhaps not to be systematically conducted, but should be selective and reserved for cases in which pre-operative needle cytology affirms malignancy, or raises suspicion.

Biopsy, Needle↗