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Biomedical subjects

M Listewnik

Publications and source records attributed to M Listewnik.

10 recordsLinked to original sources
PubMed1998

[A case of centroblastic lymphoma of the thyroid gland].

A case of a 49-year male patient with centroblastic lymphoma of the thyroid gland is presented. Centroblastic lymphoma was diagnosed with cytological and immunocytochemical examination of the biopsy specimen, and verified with histological examination of tumor section collector intraoperationally. Diagnosed tumor was classified as II AE degree. No signs of lymphocytic thyroiditis co-existing with centroblastic lymphoma were noted. The patient was treated chemically with CBVPM/AVBP regimens for 8 months. Complete remission still lasting, i.e. 96 months after completion of chemotherapy, was achieved.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1997

[Scintigraphic method in the quantification of morphological and functional changes of thyroid autonomy before and after iodine radiotherapy].

The regional excess of function and cell mass in potentially "toxic" thyroid areas with nonimmunogenic hyperthyroidism (NIH) (unifocal [UFA, previously "toxic adenoma"] and multifocal functional autonomies [MFA or "toxic goiter"]) are quantified by an enhanced diagnostic method: double isotope subtraction scintigraphy (Ssc) with radioiodine and 99mTc-MIBI. In 125 patients, a toxicity index T was derived from the Ssc (*J-*MIBI), and a cell density index Q from the *MIBI image. The median value of T, as an expression of the regional autonomous excess function (165 in UFA, 15 in MFA), by far exceeded the median value of Q (3.8 in UFA, 2.0 in MFA). The significant (p < 0.001) effects of radioiodine therapy (RIT) were monitored by the changes towards normalization of T and Q in 53 patients in follow-ups 3 and 9 months thereafter. Our aim was (a) to extend the conventional field of measurement of NIH-hyperthyroidism with the scintigraphically quantified function and morphology, and (b) to compare the return to euthyroid state with scintigraphic scarification of the functionally autonomous areas.

Contrast Media↗
PubMed1996

Separation of autonomous function from cell density in non-immunogenic hyperthyroidism--II. quantified comparison before and after radioiodine therapy.

Regional autonomous cell mass (Q: cell density ratio) and function (T: toxicity index) were compared by double isotope parametric thyroid scintigraphy (Als et al., Nucl. Med. 1995; 34) in 53 patients with non-immunogenic hyperthyroidism before and after radioiodine therapy (aRIT) and showed a break-down (medians) of Q: 4.3-->1.0 (toxic adenomas: TA), 2-->1.1 (multifocal functional autonomies: MFA)(p < 0.0001) as of T: 96-->1.7 (TA), 15-->1.1 (MFA) (p < 0.001). Five functional aRIT patterns resulted: euthyroidism (n = 37, 70%), at half with scarred/non-scarred autonomous areas (low/higher T, respectively), primary hypothyroidism (n = 4), residual hyperthyroidism (n = 7), secondary hyperthyroidism (n = 5). The last two groups with persistent subnormal TSH values were clearly separated by divergent T, thyroxine and triiodothyronine levels. A resulting T > 1 may represent a clinically sub-critical mass of residual autonomous tissue. This new technique facilitates individual pretherapeutic evaluations and aRIT quality control.

Follow-Up Studies↗
PubMed1995

Immunogenic and non-immunogenic hyperthyroidism. Recent trends in prealpine Switzerland and in coastal Poland.

Annual occurrences of immunogenic (IH) and non-immunogenic hyperthyroidism (NIH) between Berne (1976, 1982, 1991) and Szczecin (1973, 1980, 1991) were compared. Out of 21,025 patients referred for thyroid examinations, 10.1% (average) were hyperthyroid. In Berne (former endemic goiter region) and Szczecin (without goiter endemicity) IH occurred in 41% and 68%, NIH in 59% and 32% of hyperthyroid patients, respectively. Within a stable incidence of NIH in Berne, toxic adenomas (TA) decreased from 41% (1976) to 17% (1991) (p < 0.005). In Szczecin, where iodine deficiency is in an early stage, the TA frequency did not change significantly: from 24% (1973) to 28% (1991). Increases of TA or of multifocal functional autonomy apparently "mark" incipient or, respectively, decreasing deficiencies in nutritious iodine. Hyperthyroid patients in Berne compared to Szczecin were older, both with IH (54 versus 45 y) and NIH (65 versus 52 y). Age at diagnosis was stable in Berne but increasing (p < 0.05) in Szczecin (from 43 to 52 y).

Adenoma↗
PubMed1991

[Effectiveness of iodine prophylaxis and frequency of thyroid enlargement (thyroid goiter) and clinical diagnosis of thyroid diseases in inhabitants of the Szczecin region after the Czernobyl accident].

The study, supported by program MZ-XVII, was carried on 4567 inhabitants of the area of Szczecin (2350 females and 2217 males). The population was chosen randomly, according to a simple drawing scheme. All subjects were clinically examined using standardised questionnaires. In 3468 persons (including 1807 girls and women, 1661 boys and men) apart form clinical examination, the assessment of thyrotropin, thyroxine and triiodothyronine in serum and frequency of antithyroglobulin antibodies and antithyroid membrane antibodies were evaluated. The data indicate that 94% of children in Szczecin's region received the prophylactic dose of iodine, mostly between the 1st and the 5th of May 1986. Only 17% of the adults received iodine. The most common preparation was Lugol solution given in a single dose. Among all persons who received iodine, only in 5% of subjects the side effects were noted (mostly in children), including symptoms of gastrointestinal tract (vomiting, abdomen pain) and occasionally intrathyroid side effects (thyroid pains). In examined population the high frequency of thyroid enlargement, mainly in women (up to 43-44% at the age group 30-50 years) was found. The frequency of clinical diagnosis of thyroid disease was higher in women than in man (most often the diffuse goiter, rarely the nodular goiter). The frequency of thyroid enlargement and clinical diagnosis of thyroid disease was not dependent on prophylactic iodine intake. The iodine prophylaxis did not influence on thyroid hormones and TSH serum levels and on frequency of antithyroid antibodies.

Adult↗
PubMedDate not supplied

Myasthenia gravis as a complication of D-penicillamine therapy in rheumatoid arthritis.

During the period 1971-79, 301 patients in the Voivodeship Integrated Hospital in Szczecin were treated with D-penicillamine (D-PCN). The complications observed included two cases of myasthenia gravis (MG), both in rheumatoid arthritis (RA) patients, one a 41-year-old man given the drug for 8 months, the other a 50-year-old woman treated in the same way for 4 months. In both patients, pneumomediastinography revealed enlargement of the thymus. Thymectomy followed by histological examination in both cases showed the existence of germinal centres and Hassall's bodies in the typical glandular texture. Follow-up examination 3 years later confirmed complete healing in the male patient and a marked improvement in the female patient.

Adult↗