Biomedical subjects

M Louis Lauzon

Publications and source records attributed to M Louis Lauzon.

7 recordsLinked to original sources

PubMed2006

Passive catheter visualization in magnetic resonance-guided endovascular therapy using multicycle projection dephasers.

PURPOSE: To improve upon the conventional projection dephaser (PD) method of background suppression and evaluate the use of multicycle projection dephasers to improve catheter conspicuity in background-suppressed MR images. MATERIALS AND METHODS: Passive visualization of endovascular catheters in MR images is compared using two background suppression techniques: 1) the conventional PD method and 2) the multicycle PD method. Contrast-filled 4-French (1.3 mm) catheters were imaged in homogeneous and heterogeneous phantoms, and in the common carotid artery of a canine using a modified spoiled gradient echo imaging sequence. We used catheter-to-background contrast (ranging from -100% to 100%) as the metric to compare background suppression techniques. RESULTS: In the homogeneous and heterogeneous phantoms, the contrast was -6.9% (catheter darker than background) and 15.0%, respectively, using the conventional PD method, and 50.6% and 44.0%, respectively, using the multicycle PD method. In the canine carotid artery, the contrast was -3.1% using the conventional PD method and 53.0% using the multicycle PD method. CONCLUSION: This work shows that multicycle projection dephasers improve catheter conspicuity over the conventional PD method. The multicycle PD method has potential for use in guiding endovascular procedures.

Animals↗

PubMed2006

Stroke imaging at 3.0 T.

Stroke is a devastating disease with a complex pathophysiology. It is a major cause of death and disability in North America. To fully characterize its extent and effects, one requires numerous specialized anatomical and functional MR techniques, specifically diffusion-weighted imaging, MR angiography, and perfusion-weighted imaging. The advent of 3.0 T clinical scanners has the potential to provide higher quality information in potentially less time compared with 1.5 T stroke-specific MR imaging protocols. This article gives a brief overview of stroke, presents the principles and clinical applications of the relevant MR techniques required for diagnostic stroke imaging at high field, and discusses the advantages, challenges, and limitations of 3.0 T imaging as they relate to stroke.

Brain↗

PubMed2006

Time-efficient breath-hold abdominal MRI at 3.0 T.

OBJECTIVE: The purpose of this study was to increase the allowed number of acquired slices per unit time (i.e., time efficiency) for high-power deposition breath-hold abdominal acquisitions at 3.0 T. MATERIALS AND METHODS: Abdominal MRI protocols include various T1-weighted, T2-weighted, and contrast-enhanced acquisitions that require extended spatial coverage and resolution. Ideally, each acquisition is completed within one breath-hold. At 3.0 T, power deposition (i.e., specific absorption rate [SAR]) concerns can limit achieving these conflicting needs because conventional sequences are based on 6-minute time-average SAR requirements. We optimized abdominal-specific sequences based on an approved short-term 10-second time-average SAR criterion and added a delay time after breath-holding to fulfill the long-term 6-minute time-average power deposition regulation. RESULTS: Using our strategy, image acquisition time efficiency at 3.0 T was increased approximately twofold compared with conventional abdominal breath-hold pulse sequences for 2D dual-echo gradient-recalled echo, single-shot fast spin-echo, and 3D steady-state free precession sequences. Volunteers experienced a slight sensation of warmth for the single-shot fast spin-echo implementation, the most SAR-intensive sequence. CONCLUSION: Our optimization strategy is not vendor-specific, is easily implemented for all conventional scanners (provided one can access and modify the pulse sequences directly, or the vendors can make the necessary changes), yields a higher slice-per-unit-time imaging efficiency, and still satisfies all the regulatory power deposition requirements.

Abdomen↗

PubMed2005

A novel method to derive separate gray and white matter cerebral blood flow measures from MR imaging of acute ischemic stroke patients.

Perfusion-weighted imaging (PWI) measures can predict tissue outcome in acute ischemic stroke. Accuracy might be improved if differential tissue susceptibility to ischemia is considered. We present a novel voxel-by-voxel analysis to characterize cerebral blood flow (CBF) separately in gray (GM) and white matter (WM). Ten patients were scanned with inversion-recovery spin-echo EPI (IRSEPI), diffusion-weighted imaging (DWI), PWI<6 h from onset and fluid attenuated inversion-recovery (FLAIR) at 30 days. Image processing included coregistration to PWI, automatic segmentation of IRSEPI into GM, WM and CSF and semiautomatic segmentation of DWI/FLAIR to derive the acute and 30-day lesions. Five tissue compartments were defined: (1) 'Core' (abnormal acutely and at 30 days), (2) 'Growth' (or 'infarcted penumbra', abnormal only at 30 days), (3) 'Reversed' (abnormal acutely but normal at 30 days), (4) 'MTT-Delayed ' (tissue with delayed mean transit time but not part of the acute or 30-day lesion), and (5) 'Normal' brain. Cerebral blood flow in GM and WM of each compartment was obtained from quantitative maps. Gray matter and WM mean CBF in the growth region differed by 5.5 mL/100 g min (P=0.015). Mean CBF also differed significantly within normal and MTT-Delayed compartments. The difference in the reversed region approached statistical significance. In core, GM and WM CBF did not differ. The results suggest separate ischemic thresholds for GM and WM in stroke penumbra.

Aged↗

PubMed2005

MR imaging of hyperacute subarachnoid and intraventricular hemorrhage at 3T: a preliminary report of gradient echo T2*-weighted sequences.

We describe MR imaging findings applying gradient echo (GRE) T2*-weighted and fluid-attenuated inversion recovery (FLAIR) MR images at 3T to three patients with hyperacute subarachnoid and intraventricular hemorrhage from ruptured aneurysms. Hyperacute subarachnoid and intraventricular hemorrhages (SAH and IVH) were more clearly visualized as an area of decreased signal intensity on GRE T2*-weighted sequences than on FLAIR sequences in all three patients. These preliminary results suggest that acute SAH and IVH with GRE T2*-weighted imaging can be reliably diagnosed at 3T.

Acute Disease↗

PubMed2003

Magnetic resonance imaging at 3.0 Tesla: challenges and advantages in clinical neurological imaging.

MR imaging at very high field (3.0 T) is a significant new clinical tool in the modern neuroradiological armamentarium. In this report, we summarize our 40-month experience in performing clinical neuroradiological examinations at 3.0 T and review the relevant technical issues. We report on these issues and, where appropriate, their solutions. Issues examined include: increased SNR, larger chemical shifts, additional problems associated with installation of these scanners, challenges in designing and obtaining appropriate clinical imaging coils, greater acoustic noise, increased power deposition, changes in relaxation rates and susceptibility effects, and issues surrounding the safety and compatibility of implanted devices. Some of the these technical factors are advantageous (eg, increased signal-to-noise ratio), some are detrimental (eg, installation, coil design and development, acoustic noise, power deposition, device compatibility, and safety), and a few have both benefits and disadvantages (eg, changes in relaxation, chemical shift, and susceptibility). Fortunately solutions have been developed or are currently under development, by us and by others, for nearly all of these challenges. A short series of 1.5 T and 3.0 T patient images are also presented to illustrate the potential diagnostic benefits of scanning at higher field strengths. In summary, by paying appropriate attention to the discussed technical issues, high-quality neuro-imaging of patients is possible at 3.0 T.

Artifacts↗

PubMed2002

Peak velocity determination using fast Fourier velocity encoding with minimal spatial encoding.

For quantitative peak velocity determination, a technique was developed that uses Fourier velocity encoding (FVE) for the fast acquisition of images of velocity with no spatial encoding other than slice selection. The technique produces images of velocity versus temporal frequency. In applications where the quantity of interest is the peak velocity and in-plane spatial localization is not required, high SNR images are produced with reduced sensitivity to errors due to slice thickness and motion. The technique was validated using steady and pulsatile flow in a straight tube, and compared to both phase contrast measurements and numerical models using steady flow in a 50% and a 75% cosinusoidal stenosis phantom. Results show that for slices as large as 2 cm and/or undergoing periodic motion, FVE can accurately measure the peak velocity in cases where a distribution of velocities exist.

Blood Flow Velocity↗