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Biomedical subjects

M Lucarotti

Publications and source records attributed to M Lucarotti.

4 recordsLinked to original sources

Surgical care and outcome for patients in their nineties.

BACKGROUND: Surgical care of the elderly poses special problems. Very little has been published on the management of patients aged 90 years and over. METHODS: This study reviewed a consecutive series of patients aged 90 years and over, admitted to hospital over 2 years under five general surgeons and two urologists. There were 129 patients (68 per cent women) aged 90-104 (median 92) years and a total of 141 admissions, 45 elective and 96 emergency. Gastrointestinal conditions were commonest (40 per cent of admissions), followed by undiagnosed abdominal pain (16 per cent), hernia (16 per cent), arterial disease (13 per cent) and urological problems (7 per cent). RESULTS: Operation was required after 66 per cent of admissions (37 of 45 elective admissions and 56 (58 per cent) of 96 emergencies). In contrast to other studies of the very elderly, some patients were American Society of Anesthesiologists (ASA) grade 1, none of whom died after operation; no patient with ASA grade 5 was submitted to operation. Fifteen patients (12 per cent) died in hospital, three of 31 and seven of 50 respectively after elective and emergency surgery. CONCLUSION: Very elderly patients can be managed with a reasonable expectation of good outcome after admission for surgical care.

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The Gloucestershire Aneurysm Screening Programme: the first 2 years' experience.

5337 men aged 65 were invited for ultrasound examination of the abdominal aorta between September 1990 and October 1992 as part of a General Practice based aneurysm screening programme covering the County of Gloucestershire. 4232 (79%) attended. 3877 (91.6%) had aortic diameters equal to or less than 2.5 cm. 302 (7.1%) had aortic diameters in the range 2.6-3.9 cm and 53 (1.3%) had a diameter of 4.0 cm or greater. Mean aortic diameter was 2.04 cm (S.D. 0.50 cm). The practicalities, costs and benefits of a community based aneurysm screening programme are discussed.

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Evaluation of the therapeutic use of radioactive monoclonal antibodies C242 and C215 in transplanted murine tumours.

The therapeutic roles of monoclonal antibodies C242 and C215 labelled with 131I were investigated in transplanted mammary carcinomas. Fragments (10 mg) of mammary tumour from (A x Pc) F1 hybrid mice were implanted subcutaneously in 72 mice of the same strain. Twelve mice were injected with 131I-C242 starting from day 12 following tumour implantation, and eight out of 12 survived for 60 days. By contrast all but one of 36 control mice died within the same time period (P less than 0.0001). Twelve mice were injected with 131I-C215. Seven out of the 12 were alive at 60 days whilst all but 1 of 36 control animals had died (P less than 0.0001). In this study targeted immunotherapy using 131I-labelled antibodies C242 and C215 inhibited tumour growth and prolonged survival. Measurements of tumour area showed a 27-39 percent reduction in the mice receiving the radiolabelled conjugates C242 and C215 (P less than 0.004 and P = 0.028 respectively).

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